YRC Public Data Repository - Protein Structure Prediction

Protein:	gcn5
Organism:	Schizosaccharomyces pombe
Length:	454 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gcn5.

Description	E-value	Query Range	Subject Range
gi\|55645415 - gi\|55645415\|ref\|XP_511500.1\| PREDICTED: similar to GCN5 general control of amino-acid synthesis 5-li... gi\|7428978, gi\|1... - pir\|\|S71789 GCN5 protein - human, gi\|1491935\|gb\|AAC50641.1\| histone acetyltransferase	473.0	[0..1]	[446..20]
gi\|114667307 - gi\|114667307\|ref\|XP_511500.2\| PREDICTED: GCN5 general control of amino-acid synthesis 5-like 2 isofo...	469.0	[0..1]	[446..381]
gi\|73965809 - gi\|73965809\|ref\|XP_860364.1\| PREDICTED: similar to GCN5 general control of amino-acid synthesis 5-li...	469.0	[0..1]	[446..128]
gi\|28516430, gi\|... - gi\|94376478\|ref\|XP_985227.1\| PREDICTED: similar to p300/CBP-associated factor [Mus musculus], gi\|285...	466.0	[0..4]	[446..376]
gi\|50733046 - gi\|50733046\|ref\|XP_426001.1\| PREDICTED: similar to PCAF [Gallus gallus]	466.0	[0..5]	[446..506]
gi\|149054242, gi... - gi\|157817171\|ref\|NP_001100520.1\| general control of amino acid synthesis 5-like 2 [Rattus norvegicus...	464.0	[0..1]	[446..376]

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Predicted Domain #1

Region A:
Residues: [1-103]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSLNDQTR PPDSSVVDST SSNFPNASND SVHDKPVKQD EQSNPNVREA IANSDGQESL  60
   61 AVKENKDTES SSSHFVPNGV SNSKKRKLVA TDLDVDFDIS SVR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [104-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTEKPSVLEE KSGVIQFRVV SNDDTADSMI MLTGLKNIFM KQLPKMPKEY ITRLIYDRNH  60
   61 LSMTIVKDNL HVVGGITYRP FEQRGFAEIV FCAIASNEQV R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.045757
Match:	1yghA
Description:	Catalytic domain of GCN5 histone acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [205-280]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYGSHLMNHL KDYVRGTTTI QHFLTYADNY AIGYFKKQGF TKEITLDKSI WVGYIKDYEG  60
   61 GTLMQCTMIP KIKYLE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.78
Match:	1yghA
Description:	Catalytic domain of GCN5 histone acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone acetyltransferase activity	9.77190406882468	bayes_pls_golite062009
lysine N-acetyltransferase activity	9.77190406882468	bayes_pls_golite062009
N-acetyltransferase activity	9.73964376866211	bayes_pls_golite062009
N-acyltransferase activity	9.60609829597779	bayes_pls_golite062009
acetyltransferase activity	8.97813893741415	bayes_pls_golite062009
acyltransferase activity	8.29975737946923	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	8.2593462862836	bayes_pls_golite062009
transferase activity, transferring acyl groups	8.04883596198777	bayes_pls_golite062009
	6.86025120243744	bayes_pls_golite062009
H3 histone acetyltransferase activity	5.83499424263076	bayes_pls_golite062009
	3.52813815101294	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	3.06288276492113	bayes_pls_golite062009
transferase activity	2.55875279009494	bayes_pls_golite062009
transcription regulator activity	2.26346740872821	bayes_pls_golite062009
nucleic acid binding	2.14720849412601	bayes_pls_golite062009
catalytic activity	1.823104805379	bayes_pls_golite062009
binding	1.30356860355657	bayes_pls_golite062009
transcription coactivator activity	1.05620338082006	bayes_pls_golite062009
transcription factor binding	0.999468823887739	bayes_pls_golite062009
transcription activator activity	0.800725992277502	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.60912193595326	bayes_pls_golite062009
histone binding	0.511669465942587	bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity	0.333301232703043	bayes_pls_golite062009
myristoyltransferase activity	0.333301232703043	bayes_pls_golite062009
transcription cofactor activity	0.207688916644661	bayes_pls_golite062009
protein binding	0.116359302536336	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [281-454]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANLILAIQKA AVVSKINRIT RSNVVYPGLD VFKDGPAHIE PSQVPGLMEV GWCKEMEELS  60
   61 KKPRPKPFFA VLEMLFTEMQ NHPSSWPFMQ PVSKEDVPDY YEVIEHPMDL STMEFRLRNN 120
  121 QYESVEEFIR DAKYIFDNCR SYNDSNTTYY KNADRLEKFF QKKLRETEYS HLAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.0
Match:	1e6iA
Description:	GCN5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone acetyltransferase activity	9.91927576220387	bayes_pls_golite062009
lysine N-acetyltransferase activity	9.91927576220387	bayes_pls_golite062009
N-acetyltransferase activity	7.57346092874507	bayes_pls_golite062009
N-acyltransferase activity	7.12398761720889	bayes_pls_golite062009
acetyltransferase activity	6.51488433263281	bayes_pls_golite062009
acyltransferase activity	5.44980261163837	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	5.38368530556466	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	5.26899007107713	bayes_pls_golite062009
transferase activity, transferring acyl groups	5.06705016462047	bayes_pls_golite062009
	4.94702795409425	bayes_pls_golite062009
transcription regulator activity	3.81944587687526	bayes_pls_golite062009
DNA binding	3.34863990009219	bayes_pls_golite062009
nucleic acid binding	3.25178464591722	bayes_pls_golite062009
binding	3.24233563871512	bayes_pls_golite062009
histone binding	2.93206976627622	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.58609800997327	bayes_pls_golite062009
transcription coactivator activity	2.37993162280856	bayes_pls_golite062009
transcription factor binding	2.33866683789609	bayes_pls_golite062009
transcription activator activity	1.99519727421308	bayes_pls_golite062009
MyoD binding	1.89625280750577	bayes_pls_golite062009
MRF binding	1.89625280750577	bayes_pls_golite062009
chromatin binding	1.85568770971367	bayes_pls_golite062009
protein binding	1.82955314054861	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.82747962293997	bayes_pls_golite062009
protein kinase activity	1.63512839295568	bayes_pls_golite062009
transcription cofactor activity	1.60584871002187	bayes_pls_golite062009
transcription factor activity	1.30026489619787	bayes_pls_golite062009
DNA-dependent ATPase activity	1.28824771134976	bayes_pls_golite062009
protein serine/threonine kinase activity	1.15145628425168	bayes_pls_golite062009
sequence-specific DNA binding	1.08961199627679	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.07760436003896	bayes_pls_golite062009
transcription initiation factor activity	0.96034823197127	bayes_pls_golite062009
kinase activity	0.890638513095454	bayes_pls_golite062009
peroxisome proliferator activated receptor binding	0.547697825358481	bayes_pls_golite062009
structural molecule activity	0.398844600914114	bayes_pls_golite062009
transferase activity	0.321534577277088	bayes_pls_golite062009
RNA polymerase binding	0.29341314806541	bayes_pls_golite062009
transcription repressor activity	0.0167144924052265	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: