YRC Public Data Repository - Protein Structure Prediction

Protein:	cut14
Organism:	Schizosaccharomyces pombe
Length:	1172 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cut14.

Description	E-value	Query Range	Subject Range
gi\|6177744 - gi\|6177744\|dbj\|BAA06453.2\| cut14 protein [Schizosaccharomyces pombe]	313.0	[0..1]	[1172..1]
gi\|49097152, gi\|... - gi\|67539458\|ref\|XP_663503.1\| hypothetical protein AN5899.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	304.0	[0..1]	[1171..1]
gi\|25991997 - gi\|25991997\|gb\|AAN77000.1\| condensin subunit [Aspergillus nidulans]	303.0	[0..1]	[1171..1]
gi\|159129514 - gi\|159129514\|gb\|EDP54628.1\| nuclear condensin complex subunit Smc2, putative [Aspergillus fumigatus ... gi\|71001526, gi\|... - gi\|71001526\|ref\|XP_755444.1\| nuclear condensin complex subunit Smc2 [Aspergillus fumigatus Af293], g...	303.0	[0..1]	[1171..1]
gi\|32415814, gi\|... - gi\|32415814\|ref\|XP_328385.1\| hypothetical protein [Neurospora crassa], gi\|28923924\|gb\|EAA33085.1\| hy... gi\|85107158 - gi\|85107158\|ref\|XP_962321.1\| hypothetical protein NCU07679 [Neurospora crassa OR74A]	301.0	[0..1]	[1171..1]
gi\|71023505, gi\|... - gi\|71023505\|ref\|XP_761982.1\| hypothetical protein UM05835.1 [Ustilago maydis 521], ref\|XP_403450.1\| ...	301.0	[0..1]	[1170..1]
SMC2 - structural maintenance of chromosomes 2	301.0	[0..1]	[1169..1]
gi\|114625954, gi... - gi\|114625954\|ref\|XP_001137448.1\| PREDICTED: structural maintenance of chromosomes 2-like 1 isoform 1...	300.0	[0..1]	[1169..1]
gi\|73971498 - gi\|73971498\|ref\|XP_538759.2\| PREDICTED: similar to Structural maintenance of chromosome 2-like 1 pro...	300.0	[0..1]	[1169..1]

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Predicted Domain #1

Region A:
Residues: [1-172]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIEELIIDG FKSYAVRTVI SNWDDQFNAI TGLNGSGKSN ILDAICFVLG ITNMSTVRAQ  60
   61 NLQDLIYKRG QAGITRASVT IVFNNRDPAS SPIGFENHPQ VSVTRQIIMG GTSKYLINGH 120
  121 RALQQNVQNL FQSVQLNINN PNFLIMQGRI TKVLNMKATE ILSMIEEASG TR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.69897
Match:	1xewX
Description:	Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA clamp loader activity	3.69872504333327	bayes_pls_golite062009
motor activity	2.79327761685782	bayes_pls_golite062009
microtubule motor activity	2.74365461017633	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.69246499202248	bayes_pls_golite062009
pyrophosphatase activity	2.61582393123755	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.59641929642359	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.59333672868803	bayes_pls_golite062009
DNA-dependent ATPase activity	2.58390156971125	bayes_pls_golite062009
binding	2.4974940028864	bayes_pls_golite062009
transporter activity	2.17383908004663	bayes_pls_golite062009
ATPase activity	2.11122403732968	bayes_pls_golite062009
transmembrane transporter activity	2.02444700826552	bayes_pls_golite062009
ATPase activity, coupled	1.8908019270286	bayes_pls_golite062009
DNA helicase activity	1.72320119360938	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.52935820732225	bayes_pls_golite062009
cytoskeletal protein binding	1.40488517180956	bayes_pls_golite062009
hydrolase activity	1.35268825531078	bayes_pls_golite062009
helicase activity	1.33212695797068	bayes_pls_golite062009
tubulin binding	0.979946830272106	bayes_pls_golite062009
substrate-specific transporter activity	0.97700154207756	bayes_pls_golite062009
microtubule binding	0.907162506177187	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.89390151223569	bayes_pls_golite062009
ATP-dependent helicase activity	0.89390151223569	bayes_pls_golite062009
actin binding	0.883285269827407	bayes_pls_golite062009
purine nucleotide binding	0.725611289205392	bayes_pls_golite062009
nucleotide binding	0.717697610309727	bayes_pls_golite062009
purine ribonucleotide binding	0.713814218071151	bayes_pls_golite062009
ribonucleotide binding	0.713752628021599	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.654899784430321	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.608058786636536	bayes_pls_golite062009
structure-specific DNA binding	0.579644950922817	bayes_pls_golite062009
kinetochore binding	0.534490088080411	bayes_pls_golite062009
catalytic activity	0.458437698837681	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
protein binding	0.378225828131122	bayes_pls_golite062009
centromeric DNA binding	0.322818640526369	bayes_pls_golite062009
double-stranded DNA binding	0.2192434828134	bayes_pls_golite062009
ATP binding	0.19169045543599	bayes_pls_golite062009
adenyl ribonucleotide binding	0.165732470448462	bayes_pls_golite062009
adenyl nucleotide binding	0.162060759063149	bayes_pls_golite062009
dynein binding	0.150959629961177	bayes_pls_golite062009
active transmembrane transporter activity	0.114463153989353	bayes_pls_golite062009
microfilament motor activity	0.10236059675512	bayes_pls_golite062009
ion transmembrane transporter activity	0.081265446432119	bayes_pls_golite062009
recombinase activity	0.0490751527151101	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [173-502]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEERKEKAF RTMQRKEAKV EEINTLLREE IEPRLTKLRT EKKTFLEYQH IYNDLERLSH  60
   61 LCTAYDYYKL SLKVEELTVQ ASQKHSHIAE MESSLQTSKQ EVLILKEKIK KIEDERMRQM 120
  121 SVSSDRTLDS QLQTVNENIT RISTSIELKN TALEEEHGDL QQIRGKAKEL ETLLRGKRKR 180
  181 LDEVLSVYEK RKDEHQSISK DFKSQEELIS SLTTGLSTTE GHETGYSRKL HEARDTLNDF 240
  241 KAEKETNRLK LEGLNKQISL TKPKKAEATK RCDQLNREID ILQNHVEKLK MSLKNTNSDI 300
  301 TGEDVLQQKL KQLAKDRGNL LNELDALKSK

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.76
Match:	1c1gA
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [503-723]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAYMEFTYTD PTPNFDRSKV KGLVAQLLTL NEENYDKQTA LEITAGGRLY NLIVETEKIG  60
   61 AQLLQKGNLK RRVTIIPLNK ITSFVASAER VGAAKKISNN KAQLALELIG YDDELLPAMQ 120
  121 YVFGSTLVCD TPESAKKVTF HPSVKLKSVT LDGDVYDPSG TLTGGSVNKS AGPLLQIQKL 180
  181 NSLQLKLQVV TSEYEKLETQ LKDLKTQNAN FHRLEQEIQL K

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.73
Match:	1gxlA
Description:	Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.7707163143035	bayes_pls_golite062009
protein binding	1.2343536336523	bayes_pls_golite062009
structure-specific DNA binding	0.56283355879326	bayes_pls_golite062009
protein heterodimerization activity	0.511272811276509	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.299763949828861	bayes_pls_golite062009
DNA secondary structure binding	0.284996962785104	bayes_pls_golite062009
pyrophosphatase activity	0.248383422632029	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.235472660839816	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.233111707634177	bayes_pls_golite062009
protein dimerization activity	0.210107708818734	bayes_pls_golite062009
sequence-specific DNA binding	0.155323194767055	bayes_pls_golite062009
double-stranded DNA binding	0.101477244722795	bayes_pls_golite062009
ATPase activity	0.08869715759545	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [724-1014]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHELTLLIEQ RETDSSFRLL SDYQQYKDDV KDLKQRLPEL DRLILQSDQA IKKIERDMQE  60
   61 WKHNKGSKMA ELEKEFNQYK HKLDEFTPIL EKSENDYNGV KLECEQLEGE LQNHQQSLVQ 120
  121 GESTTSLIKT EIAELELSLV NEEHNRKKLT ELIEIESAKF SGLNKEIDSL STSMKTFESE 180
  181 INNGELTIQK LNHEFDRLER EKSVAITAIN HLEKENDWID GQKQHFGKQG TIFDFHSQNM 240
  241 RQCREQLHNL KPRFASMRKA INPKVMDMID GVEKKEAKLR SMIKTIHRDK K

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [1015-1172]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIQDTVKSID RFKRSALEKT WREVNSSFGE IFDELLPGNS AELQPPENKE FTDGLEIHVK  60
   61 IGSIWKDSLA ELSGGQRSLV ALALIMSLLK YKPAPMYILD EIDAALDLSH TQNIGRLIKT 120
  121 KFKGSQFIIV SLKEGMFTNA NRLFHVRFMD GSSVVQAR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.39794
Match:	1xewY
Description:	Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: