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View Structure Prediction Details

Protein: gi|28571080, gi|...
Organism: Drosophila melanogaster
Length: 1427 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|28571080, gi|....

Description E-value Query
Range
Subject
Range
svr-PD - The gene silver is referred to in FlyBase by the symbol Dmel\svr (CG4122, FBgn0004648). It is a prot...
1082.0 [0..1] [1427..1]

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Predicted Domain #1
Region A:
Residues: [1-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFFCLALII GCAVGEYSEV RVIQEEDNFL ESPHYLKNEE IGDLFSQLAK DYPDLAQTYT  60
   61 IGKSLEDRPI YALALSAPTG ESKNGDLLRP MVKLVANIQG DEAVGRQMVL YMAEYLATHY 120
  121 DGDPKVQALL NLTEIHFLPT CNPDGFAKAK VSHLLFLAYQ ESTESKFWNG KMIEGNCESL 180
  181 PNYVGRGNAA NIDLNRDFPD RLEQSHVHQL RAQSRQPETA ALVNWIVSKP FVLSANFHGG 240
  241 AVVASYPYDN SLAHNECCEE SLTPDDRVFK QLAHTYSDNH PIMRKGNNCN DSFSGGITNG 300
  301 AHWYELSGGM QDFNYAFSNC FELTIELSCC KYPAASTLPQ EWQRNKASLL QLLRQAHIGI 360
  361 KGLVTDASGF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.69897
Match: 1ayeA
Description: HUMAN PROCARBOXYPEPTIDASE A2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.786910294594 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.40766568731738 bayes_pls_golite062009
exopeptidase activity 3.28577934113028 bayes_pls_golite062009
hydrolase activity 2.98013991489506 bayes_pls_golite062009
metallopeptidase activity 2.76103081380105 bayes_pls_golite062009
carboxypeptidase activity 2.63658263814587 bayes_pls_golite062009
metalloexopeptidase activity 1.76058821499096 bayes_pls_golite062009
metallocarboxypeptidase activity 1.56827526553175 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
binding 1.32879486130719 bayes_pls_golite062009
nucleic acid binding 0.968016926667625 bayes_pls_golite062009
endopeptidase activity 0.910234727191613 bayes_pls_golite062009
transcription regulator activity 0.738552659762097 bayes_pls_golite062009
serine hydrolase activity 0.596149133958797 bayes_pls_golite062009
serine-type peptidase activity 0.578572340123331 bayes_pls_golite062009
DNA binding 0.508098629093675 bayes_pls_golite062009
cobalt ion binding 0.373334141253719 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009
protein binding 0.00854198798870509 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [371-783]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIADANVYVA GLEEKPMRTS KRGEYWRLLT PGLYSVHASA FGYQTSAPQQ VRVTNDNQEA  60
   61 LRLDFKLAPV ETNFDGNFRK VKVERSEPPQ KLKKQFNGFL TPTKYEHHNF TAMESYLRAI 120
  121 SSSYPSLTRL YSIGKSVQGR DLWVLEIFAT PGSHVPGVPE FKYVANMHGN EVVGKELLLI 180
  181 LTKYMLERYG NDDRITKLVN GTRMHFLYSM NPDGYEISIE GDRTGGVGRA NAHGIDLNRN 240
  241 FPDQYGTDRF NKVTEPEVAA VMNWTLSLPF VLSANLHGGS LVANYPFDDN ENDFNDPFMR 300
  301 LRNSSINGRK PNPTEDNALF KHLAGIYSNA HPTMYLGQPC ELFQNEFFPD GITNGAQWYS 360
  361 VTGGMQDWNY VRAGCLELTI EMGCDKFPKA AELSRYWEDH REPLLQFIEQ VHC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.0
Match: 1jqgA
Description: Carboxypeptidase A; Procarboxypeptidase A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.786910294594 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.40766568731738 bayes_pls_golite062009
exopeptidase activity 3.28577934113028 bayes_pls_golite062009
hydrolase activity 2.98013991489506 bayes_pls_golite062009
metallopeptidase activity 2.76103081380105 bayes_pls_golite062009
carboxypeptidase activity 2.63658263814587 bayes_pls_golite062009
metalloexopeptidase activity 1.76058821499096 bayes_pls_golite062009
metallocarboxypeptidase activity 1.56827526553175 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
binding 1.32879486130719 bayes_pls_golite062009
nucleic acid binding 0.968016926667625 bayes_pls_golite062009
endopeptidase activity 0.910234727191613 bayes_pls_golite062009
transcription regulator activity 0.738552659762097 bayes_pls_golite062009
serine hydrolase activity 0.596149133958797 bayes_pls_golite062009
serine-type peptidase activity 0.578572340123331 bayes_pls_golite062009
DNA binding 0.508098629093675 bayes_pls_golite062009
cobalt ion binding 0.373334141253719 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009
protein binding 0.00854198798870509 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [784-873]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIHGFVHSTI GTPIAGAVVR LDGANHSTYS QVFGDYWKLA LPGRHNLTVL GDNYAPLRME  60
   61 VEVPDVHPFE MRMDITLMPD DPQHWASAND 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.0
Match: 1h8lA
Description: Carboxypeptidase D, a regulatory domain; Carboxypeptidase D, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [874-1241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRIIENVVNT RYHTNPQVRA RLAELENQNG QIASFGYADS EFGTIFNYLK MTSDIGEPEE  60
   61 HKYKLLVVSS LYDTTAPLGR EILLNLIRHL VEGFKLQDTS VVELLKRSVI YFLPQTSKFQ 120
  121 NVFDMYNSNT SICDPVLGDE LAERILGPET DQAKDVFLQF LRSERFDLML TFGAGNSDLN 180
  181 YPKGDSVLVK FAHRMQRTEF NYSPLQCPPS ATRQLHRETT ERLTNMMYRI YNLPVYTLGI 240
  241 SCCRMPHQKK IASVWRKNID KIKNFLALVK TGVSGLVQND KGQPLREAYV RLLEHDRIIN 300
  301 VTKNVARFQL MLPHGLYGLE VTAPNYESQM IKVDVEDGRV TELGIIRMHP FTLIRGVVLE 360
  361 LPNNDNRA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 8.73
Match: 2nsmA
Description: No description for 2nsmA was found.

Predicted Domain #5
Region A:
Residues: [1242-1349]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTSIAGVVLD ESNHPVRNAK VSVVGQTQLR NFTGSMGQYR ISAVPLGTIT LKVEAPRHLE  60
   61 ATRQMHLIQG GLATENVVFH LKVNEHVFGL PRFLFILCAS VLIIVGVI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.23
Match: 2pz4A
Description: No description for 2pz4A was found.

Predicted Domain #6
Region A:
Residues: [1350-1427]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VCVLCAQFWF YRRHRGDKPY YNFSLLPQRG KEQFGLEDDD GGDDGETELF RSPIKRELSQ  60
   61 RAHLVNNQTN YSFIIQAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle