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View Structure Prediction Details

Protein: Ance-5-PA
Organism: Drosophila melanogaster
Length: 628 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ance-5-PA.

Description E-value Query
Range
Subject
Range
ACET_RAT - Angiotensin-converting enzyme, testis-specific isoform OS=Rattus norvegicus GN=Ace PE=2 SV=1
634.0 [0..11] [626..99]

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Predicted Domain #1
Region A:
Residues: [1-628]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLPFLGVSL ILLLSVTFGI GQSSYELATK QILDRAKDRM RHVWSLNRRI FVQLTAKGKS  60
   61 PLGGQVLNSK LEVEAETYRL FYDLAGNLSV VSVAELNDPL LRRRVQRMAK LQLQGLRPKD 120
  121 YEQAKDLLRQ IHNFVNGPLV CPYEDCSARG SLAMYPQIMN KNMHTKLYED LVINWKAWRR 180
  181 AINEKDVAKN TFIGYVRLLR IAATYNGHVT PSRTWYLNYD TENFQAEMEA VVWEIMPLYR 240
  241 ELHAYLRREV QAAYPKADTK SDGAISAPIM DQILSQDWYP HQFFRTPHQG RQHQLPSVHR 300
  301 RLEEVLVTPV KINRKAAEFF ESLGLMVMPN IFYDRFSRRM NDEEGGAECK SQVYYFPPDV 360
  361 ALRYCPKLDY KKMMQIHGTM AELQYHLYKM QLPFGLDTEP CPGFGAAIAE TVILASGTPR 420
  421 HLHRLHILLN DSLTEEQSLN RLFRMGVHTL IAVPQYFIND KFLVDVMDGR IGVKDYNCAY 480
  481 WGLQDKFAGV QPPLQRLNKD FDVDFKFYRG LNPETSNTKK FLAEILGFQF YRSFCLASGQ 540
  541 YKPGDPNFPL HNCDFYDSKE AGKKIRDMMQ LGATRHWRDV MEIATGERKL SGRGILEYFA 600
  601 PLFTWLKERN KQLDIEPGWD ADELCRRD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 176.0
Match: 1o86A
Description: Angiotensin convering enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 5.33358263548929 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.99457783001146 bayes_pls_golite062009
bradykinin receptor binding 4.68498310889748 bayes_pls_golite062009
endopeptidase activity 4.16532996235931 bayes_pls_golite062009
metallopeptidase activity 3.94798058866011 bayes_pls_golite062009
metalloendopeptidase activity 3.43236442601127 bayes_pls_golite062009
peptidyl-dipeptidase activity 3.15882456934259 bayes_pls_golite062009
hydrolase activity 2.61181165622708 bayes_pls_golite062009
exopeptidase activity 2.07461908743946 bayes_pls_golite062009
integrin binding 1.58328929324965 bayes_pls_golite062009
binding 1.55761777216628 bayes_pls_golite062009
protein complex binding 1.52308144668596 bayes_pls_golite062009
epoxide hydrolase activity 1.37998417474643 bayes_pls_golite062009
transporter activity 1.28982382930122 bayes_pls_golite062009
receptor binding 1.20826493144754 bayes_pls_golite062009
ether hydrolase activity 1.18753073809881 bayes_pls_golite062009
transmembrane transporter activity 1.0688261398267 bayes_pls_golite062009
catalytic activity 0.891187593353827 bayes_pls_golite062009
substrate-specific transporter activity 0.798767221679673 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.543737159152136 bayes_pls_golite062009
protein binding 0.530727556830171 bayes_pls_golite062009
zinc ion binding 0.49304764842799 bayes_pls_golite062009
hydrolase activity, acting on ether bonds 0.457157426475929 bayes_pls_golite062009
serine hydrolase activity 0.393080846858665 bayes_pls_golite062009
serine-type peptidase activity 0.374597710524442 bayes_pls_golite062009
glycosaminoglycan binding 0.369102282817767 bayes_pls_golite062009
serine-type endopeptidase activity 0.252655558968584 bayes_pls_golite062009
ion transmembrane transporter activity 0.241890854867053 bayes_pls_golite062009
aminopeptidase activity 0.21808506596674 bayes_pls_golite062009
transition metal ion binding 0.21514043665594 bayes_pls_golite062009
signal transducer activity 0.120905338073793 bayes_pls_golite062009
molecular transducer activity 0.120905338073793 bayes_pls_golite062009
angiotensin receptor activity 0.0133022345809808 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle