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View Structure Prediction Details

Protein: Vps25-PA
Organism: Drosophila melanogaster
Length: 174 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Vps25-PA.

Description E-value Query
Range
Subject
Range
gi|109489035 - gi|109489035|ref|XP_001060127.1| PREDICTED: similar to Vacuolar protein sorting protein 25 (ELL-asso...
285.0 [0..3] [174..189]
VPS25_DANRE - Vacuolar protein-sorting-associated protein 25 OS=Danio rerio GN=vps25 PE=2 SV=2
272.0 [0..3] [174..2]
gi|73965636 - gi|73965636|ref|XP_849270.1| PREDICTED: similar to Serine/threonine-protein kinase WNK4 (Protein kin...
271.0 [0..3] [174..30]
gi|47220639 - gi|47220639|emb|CAG06561.1| unnamed protein product [Tetraodon nigroviridis]
271.0 [0..3] [174..3]
VPS25_MOUSE - Vacuolar protein-sorting-associated protein 25 OS=Mus musculus GN=Vps25 PE=1 SV=1
gi|55716005 - gb|AAH86063.1| Unknown (protein for MGC:98421) [Xenopus laevis]
tr|G3HLY6|G3HLY6... - Vacuolar protein-sorting-associated protein 25 OS=Cricetulus griseus GN=I79_011730 PE=4 SV=1
268.0 [0..3] [174..4]
VPS25_BOVIN - Vacuolar protein-sorting-associated protein 25 OS=Bos taurus GN=VPS25 PE=2 SV=1
266.0 [0..3] [174..4]
gi|62859513, gi|... - gi|62859513|ref|NP_001016078.1| vacuolar protein sorting 25 [Xenopus (Silurana) tropicalis], gi|1131...
266.0 [0..4] [174..3]

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Predicted Domain #1
Region A:
Residues: [1-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEFQWPWEY TFPPFFTLQP HEETRQQQLK VWTDLFLKYL RHTNRFTLSI GDQNSPLFHN  60
   61 EALKRRLSPE LVLAILGELE RSGHANPLDK RRQEWQVYWF TLEEYGNMVY DWVQETGQTN 120
  121 TICTLYEIAS GENTSHLDFY GVDEAVLLSA LRLLEEKGRC ELIEMDGSHG VKFF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.30103
Match: 1u5tC
Description: Structure of the ESCRT-II endosomal trafficking complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.35380365970626 bayes_pls_golite062009
transferase activity 1.0863867010063 bayes_pls_golite062009
molecular transducer activity 0.968719315363638 bayes_pls_golite062009
signal transducer activity 0.968719315363638 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009
structure-specific DNA binding 0.217544912085963 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009

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