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Protein Overview: Vps25-PA

General Information:
Name(s) found: Vps25-PA / FBpp0087774 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Vacuolar protein sorting 25 is referred to in FlyBase by the symbol Dmel\Vps25 (CG14750, FBgn0022027). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4512956..4513685. It has the cytological map location 44D5. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: regulation of apoptosis; regulation of multivesicular body size involved in endosome transport; cell proliferation; negative regulation of epithelial cell proliferation; endosome transport via multivesicular body sorting pathway; epithelial structure maintenance; maintenance of epithelial cell apical/basal polarity; cell differentiation; endosome transport. 16 alleles are reported. The phenotype of these alleles is annotated with: larval digestive system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 174 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: cell proliferation [IMP]
    maintenance of epithelial cell apical/basal polarity [IMP]
    epithelial structure maintenance [IMP]
    endosome transport via multivesicular body sorting pathway [IMP]
    negative regulation of epithelial cell proliferation [IMP]
    endosome transport [IMP][NAS]
    cell differentiation [IMP]
    regulation of multivesicular body size involved in endosome transport [IDA]
    regulation of apoptosis [IMP]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEFQWPWEY TFPPFFTLQP HEETRQQQLK VWTDLFLKYL RHTNRFTLSI GDQNSPLFHN  60
   61 EALKRRLSPE LVLAILGELE RSGHANPLDK RRQEWQVYWF TLEEYGNMVY DWVQETGQTN 120
  121 TICTLYEIAS GENTSHLDFY GVDEAVLLSA LRLLEEKGRC ELIEMDGSHG VKFF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] PSI-BLAST 54.30103 Structure of the ESCRT-II endosomal trafficking complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.48053910222825 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.35380365970626 bayes_pls_golite062009
  • transferase activity
    		•  1.0863867010063 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.968719315363638 bayes_pls_golite062009
  • signal transducer activity
    		•  0.968719315363638 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.217544912085963 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.136726704233672 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle