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View Structure Prediction Details

Protein: gi|123998543, gi...
Organism: synthetic construct
Length: 719 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123998543, gi....

Description E-value Query
Range		 Subject
Range
gi|74210112 - gi|74210112|dbj|BAE21331.1| unnamed protein product [Mus musculus]
 0.0 [1..719] [1..720]
gi|2134885, gi|1... - pir||S70583 replication licensing factor MCM7 - human, gi|1255617|dbj|BAA09534.1| P1cdc47 [Homo sap...
 0.0 [1..719] [1..719]
gi|82658782, gi|... - gi|93205069|ref|NP_001004203.2| minichromosome maintenance protein 7 [Rattus norvegicus], gi|8265878...
 0.0 [1..719] [1..719]
MCM7_BOVIN - DNA replication licensing factor MCM7 OS=Bos taurus GN=MCM7 PE=2 SV=1
 0.0 [1..719] [1..719]
gi|109066027 - gi|109066027|ref|XP_001101053.1| PREDICTED: minichromosome maintenance protein 7 [Macaca mulatta]
gi|67971712 - gi|67971712|dbj|BAE02198.1| unnamed protein product [Macaca fascicularis]
 0.0 [1..719] [1..719]
gi|73957890 - gi|73957890|ref|XP_849809.1| PREDICTED: similar to DNA replication licensing factor MCM7 (CDC47 homo...
 0.0 [1..719] [1..719]

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Predicted Domain #1
Region A:
Residues: [1-172] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP  60
   61 ELVDSICENA RRYAKLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR 120
  121 SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.39794
Match: 1ltlA
Description: DNA replication initiator (cdc21/cdc54) N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [173-590] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKPKMVVATY TCDQCGAETY QPIQSPTFMP LIMCPSQECQ TNRSGGRLYL QTRGSRFIKF  60
   61 QEMKMQEHSD QVPVGNIPRS ITVLVEGENT RIAQPGDHVS VTGIFLPILR TGFRQVVQGL 120
  121 LSETYLEAHR IVKMNKSEDD ESGAGELTRE ELRQIAEEDF YEKLAASIAP EIYGHEDVKK 180
  181 ALLLLLVGGV DQSPRGMKIR GNINICLMGD PGVAKSQLLS YIDRLAPRSQ YTTGRGSSGV 240
  241 GLTAAVLRDS VSGELTLEGG ALVLADQGVC CIDEFDKMAE ADRTAIHEVM EQQTISIAKA 300
  301 GILTTLNARC SILAAANPAY GRYNPRRSLE QNIQLPAALL SRFDLLWLIQ DRPDRDNDLR 360
  361 LAQHITYVHQ HSRQPPSQFE PLDMKLMRRY IAMCREKQPM VPESLADYIT AAYVEMRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 1ksfX
Description: N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 4.91429252297969 bayes_pls_golite062009
protein-DNA loading ATPase activity 4.80695929076807 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.66107861968804 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
telomeric DNA binding 2.0142766759353 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
microtubule motor activity 1.6537049553461 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
DNA replication origin binding 1.62491387774159 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
structure-specific DNA binding 1.20315703345493 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
histone acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
double-stranded DNA binding 1.05408274676326 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.8469248456592 bayes_pls_golite062009
single-stranded telomeric DNA binding 0.700780808446722 bayes_pls_golite062009
kinase activity 0.641541011250583 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.584453361662212 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
single-stranded DNA binding 0.406600732518248 bayes_pls_golite062009
protein kinase activity 0.351308564667977 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.156278588350022 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
mismatched DNA binding 0.13366911641814 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.0223627159838333 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [591-719] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAWASKDATY TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ  60
   61 TARTQRPADV IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN 120
  121 ASRTRITFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.69897
Match: 1ojlA
Description: Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle