YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|1736875, gi\|8...
Organism:	Escherichia coli str. K-12 substr. W3110
Length:	461 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|1736875, gi|8....

Description	E-value	Query Range	Subject Range
gi\|93451451, gi\|... - gi\|94268821\|ref\|ZP_01291291.1\| Response regulator receiver [delta proteobacterium MLMS-1], gi\|934514...	413.0	[0..4]	[459..1]
gi\|75243036, gi\|... - gi\|75243036\|ref\|ZP_00726742.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A... gi\|91211514, gi\|... - gi\|91211514\|ref\|YP_541500.1\| acetoacetate metabolism regulatory protein AtoC [Escherichia coli UTI89... gi\|218559138, gi... - gi\|218559138\|ref\|YP_002392051.1\| acetoacetate metabolism regulatory protein AtoC [Escherichia coli S... gi\|110344022, gi... - gi\|110642430\|ref\|YP_670160.1\| acetoacetate metabolism regulatory protein AtoC [Escherichia coli 536]... gi\|218427947, gi... - gi\|218690383\|ref\|YP_002398595.1\| acetoacetate metabolism regulatory protein AtoC [Escherichia coli E... gi\|115513538, gi... - gi\|117624414\|ref\|YP_853327.1\| acetoacetate metabolism regulatory protein AtoC [Escherichia coli APEC... gi\|237704695, gi... - gi\|237704695\|ref\|ZP_04535176.1\| acetoacetate metabolism regulatory protein AtoC [Escherichia sp. 3_2... gi\|227835628, gi... - gi\|227887278\|ref\|ZP_04005083.1\| acetoacetate metabolism regulatory protein AtoC [Escherichia coli 83... gi\|26109014, gi\|... - gi\|26248609\|ref\|NP_754649.1\| acetoacetate metabolism regulatory protein AtoC [Escherichia coli CFT07...	412.0	[0..1]	[461..1]
gi\|74312742, gi\|... - gi\|74312742\|ref\|YP_311161.1\| acetoacetate metabolism regulatory protein AtoC [Shigella sonnei Ss046]...	411.0	[0..1]	[461..1]
gi\|134299175, gi... - gi\|88944680\|ref\|ZP_01147905.1\| Helix-turn-helix, Fis-type [Desulfotomaculum reducens MI-1], gi\|88925...	410.0	[0..2]	[457..1]
gi\|46581622, gi\|... - gi\|46581622\|ref\|YP_012430.1\| sigma-54 dependent transcriptional regulator/response regulator [Desulf... gi\|241908558, gi... - gi\|241908558\|ref\|ZP_04793124.1\| two component, sigma54 specific, transcriptional regulator, Fis fami...	408.0	[0..1]	[456..1]
gi\|77546022, gi\|... - gi\|77919939\|ref\|YP_357754.1\| two component signal transduction response regulator [Pelobacter carbin...	408.0	[0..4]	[459..1]
gi\|91202527 - gi\|91202527\|emb\|CAJ72166.1\| strongly similar to sigma 54 response regulator [Candidatus Kuenenia stu...	407.0	[0..2]	[456..1]
gi\|120601219, gi... - gi\|120601219\|ref\|YP_965619.1\| two component, sigma54 specific, Fis family transcriptional regulator ...	407.0	[0..1]	[456..1]
gi\|71486651, gi\|... - gi\|71547773\|ref\|ZP_00668332.1\| Helix-turn-helix, Fis-type [Syntrophobacter fumaroxidans MPOB], gi\|71...	406.0	[0..1]	[460..1]
gi\|85774842, gi\|... - gi\|86158331\|ref\|YP_465116.1\| two component, sigma54 specific, Fis family transcriptional regulator [...	405.0	[0..4]	[457..1]

Back

Predicted Domain #1

Region A:
Residues: [1-391]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAINRILIV DDEDNVRRML STAFALQGFE THCANNGRTA LHLFADIHPD VVLMDIRMPE  60
   61 MDGIKALKEM RSHETRTPVI LMTAYAEVET AVEALRCGAF DYVIKPFDLD ELNLIVQRAL 120
  121 QLQSMKKEIR HLHQALSTSW QWGHILTNSP AMMDICKDTA KIALSQASVL ISGESGTGKE 180
  181 LIARAIHYNS RRAKGPFIKV NCAALPESLL ESELFGHEKG AFTGAQTLRQ GLFERANEGT 240
  241 LLLDEIGEMP LVLQAKLLRI LQEREFERIG GHQTIKVDIR IIAATNRDLQ AMVKEGTFRE 300
  301 DLFYRLNVIH LILPPLRDRR EDISLLANHF LQKFSSENQR DIIDIDPMAM SLLTAWSWPG 360
  361 NIRELSNVIE RAVVMNSGPI IFSEDLPPQI R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.69897
Match:	1ny5A
Description:	Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.95073642969863	bayes_pls_golite062009
pyrophosphatase activity	1.91141407779641	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.9017593265179	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.90014393273511	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.82370030183942	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.79922369980544	bayes_pls_golite062009
transporter activity	1.55572428045529	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.52217781539459	bayes_pls_golite062009
ATPase activity	1.48474288797022	bayes_pls_golite062009
two-component response regulator activity	1.45919623810582	bayes_pls_golite062009
amine transmembrane transporter activity	1.4031990658196	bayes_pls_golite062009
transmembrane transporter activity	1.38483976298883	bayes_pls_golite062009
ATPase activity, coupled	1.37457738689583	bayes_pls_golite062009
catalytic activity	1.37148167194523	bayes_pls_golite062009
binding	1.30574971150356	bayes_pls_golite062009
active transmembrane transporter activity	1.24278046928678	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.2014318795788	bayes_pls_golite062009
primary active transmembrane transporter activity	1.19670408144267	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.17063957238561	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	1.16918853509059	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	1.16885789920943	bayes_pls_golite062009
hydrolase activity	1.09839981963412	bayes_pls_golite062009
nucleic acid binding	0.900561861643259	bayes_pls_golite062009
transcription regulator activity	0.530058973650498	bayes_pls_golite062009
purine ribonucleotide binding	0.5127850474754	bayes_pls_golite062009
ribonucleotide binding	0.51230334374838	bayes_pls_golite062009
purine nucleotide binding	0.50688037036449	bayes_pls_golite062009
protein binding	0.502813311049029	bayes_pls_golite062009
nucleotide binding	0.49473184426584	bayes_pls_golite062009
DNA binding	0.460315660888175	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.32754685224555	bayes_pls_golite062009
amine-transporting ATPase activity	0.128277449580549	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.109938795198381	bayes_pls_golite062009
substrate-specific transporter activity	0.0838665746103899	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [392-461]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPVCNAGEVK TAPVGERNLK EEIKRVEKRI IMEVLEQQEG NRTRTALMLG ISRRALMYKL  60
   61 QEYGIDPADV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.154902
Match:	1ojlA
Description:	Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: