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View Structure Prediction Details

Protein: Dscam-PH
Organism: Drosophila melanogaster
Length: 2017 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PH.

Description E-value Query
Range
Subject
Range
Dscam-PM - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
1541.0 [0..3] [2017..3]

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Predicted Domain #1
Region A:
Residues: [1-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVAQY YEADV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.522879
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [146-239]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKEHVIRGNS AVIKCLIPSF VADFVEVVSW HTDEEENYFP GAEYDGKYLV LPSGELHIRE  60
   61 VGPEDGYKSY QCRTKHRLTG ETRLSATKGR LVIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 2e9wA
Description: No description for 2e9wA was found.

Predicted Domain #3
Region A:
Residues: [240-899]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPVGSVAPKL NFLERFKMMQ IQSGTSFNIQ CPVQSYPMPV FKWYKFIEGT TRKQAVVLND  60
   61 RVKQVSGTLI IKDAVVEDSG KYLCVVNNSV GGESVETVLT VTAPLSAKID PPTQTVDFGR 120
  121 PAVFTCQYTG NPIKTVSWMK DGKAIGHSEP VLRIESVKKE DKGMYQCFVR NDQESAEASA 180
  181 ELKLGGRFDP PVIRQAFQEE TMEPGPSVFL KCVAGGNPTP EISWELDGKK IANNDRYQVG 240
  241 QYVTVNGDVV SYLNITSVHA NDGGLYKCIA KSKVGVAEHS AKLNVYGLPY IRQMEKKAIV 300
  301 AGETLIVTCP VAGYPIDSIV WERDNRALPI NRKQKVFPNG TLIIENVERN SDQATYTCVA 360
  361 KNQEGYSARG SLEVQVMVPP QIRPFDFGDE ASNSGETMGI QCTVIKGDLP INITWVLNNH 420
  421 TLNSGDLDVV IGRMSSKSST LNIDYIAAEH RGVYTCLARN QAGESSYSAE LKVNVPPRWI 480
  481 LEPTDKAFAQ GSDAKVECKA DGFPKPQVTW KKAVGDTPGE YKDLKKSDNI RVEEGTLHVD 540
  541 NIQKTNEGYY LCEAINGIGS GLSAVIMISV QAPPEFTEKL RNQTARRGEP AVLQCEAKGE 600
  601 KPIGILWNMN NMRLDPKNDN RYTIREEILS TGVMSSLSIK RTERSDSALF TCVATNAFGS 660
  661 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.30103
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [900-936]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDASINMIVQ EVPEMPYALK VLDKSGRSVQ LSWAQPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.0
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #5
Region A:
Residues: [937-1312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGNSPLDRYI IEFKRSRASW SEIDRVIVPG HTTEAQVQKL SPATTYNIRI VAENAIGTSQ  60
   61 SSEAVTIITA EEAPSGKPQN IKVEPVNQTT MRVTWKPPPR TEWNGEILGY YVGYKLSNTN 120
  121 SSYVFETINF ITEEGKEHNL ELQNLRVYTQ YSVVIQAFNK IGAGPLSEEE KQFTAEGTPS 180
  181 QPPSDTACTT LTSQTIRVGW VSPPLESANG VIKTYKVVYA PSDEWYDETK RHYKKTASSD 240
  241 TVLHGLKKYT NYTMQVLATT AGGDGVRSVP IHCQTEPDVP EAPTDVKALV MGNAAILVSW 300
  301 RPPAQPNGII TQYTVYSKAE GAETETKTQK VPHYQMSFEA TELEKNKPYE FWVTASTTIG 360
  361 EGQQSKSIVA MPSDQV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.045757
Match: 2dtgE
Description: No description for 2dtgE was found.

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
transmembrane receptor activity 4.81256300373074 bayes_pls_golite062009
ankyrin binding 4.69755754047169 bayes_pls_golite062009
receptor activity 4.66147271961356 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
molecular transducer activity 3.69234048247377 bayes_pls_golite062009
signal transducer activity 3.69234048247377 bayes_pls_golite062009
extracellular matrix structural constituent 3.5949595622742 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
receptor binding 2.38673889309915 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
mercury ion binding 1.85843060232985 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
glycosaminoglycan binding 1.56410665522466 bayes_pls_golite062009
myosin light chain kinase activity 1.49217960276915 bayes_pls_golite062009
protein kinase activity 1.42856560840953 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 1.27192437373177 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
growth hormone receptor activity 1.15929762138929 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.15899955607967 bayes_pls_golite062009
heparin binding 1.15000556789505 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.12142142875217 bayes_pls_golite062009
kinase activity 1.11027658115625 bayes_pls_golite062009
cytokine activity 1.09433218752101 bayes_pls_golite062009
structural molecule activity 0.94240190391222 bayes_pls_golite062009
peptide binding 0.92031154055894 bayes_pls_golite062009
interleukin-6 binding 0.888638861691021 bayes_pls_golite062009
interleukin-6 receptor activity 0.888638861691021 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
collagen binding 0.593745877718282 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
polysaccharide binding 0.54737137289904 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
cytokine receptor binding 0.47107517390107 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
pattern binding 0.44460010885883 bayes_pls_golite062009
growth factor activity 0.432629984792427 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
cell surface binding 0.366415248711076 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protease binding 0.12595904253108 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009
interleukin-11 receptor activity 0.0423783987133706 bayes_pls_golite062009
interleukin-11 binding 0.0423783987133706 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1313-1404]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAKIASFDDT FTATFKEDAK MPCLAVGAPQ PEITWKIKGV EFSANDRMRV LPDGSLLIKS  60
   61 VNRQDAGDYS CHAENSIAKD SITHKLIVLA PP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1tdqA
Description: Structural basis for the interactions between tenascins and the C-type lectin domains from lecticans: evidence for a cross-linking role for tenascins
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
transmembrane receptor activity 4.81256300373074 bayes_pls_golite062009
ankyrin binding 4.69755754047169 bayes_pls_golite062009
receptor activity 4.66147271961356 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
molecular transducer activity 3.69234048247377 bayes_pls_golite062009
signal transducer activity 3.69234048247377 bayes_pls_golite062009
extracellular matrix structural constituent 3.5949595622742 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
receptor binding 2.38673889309915 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
mercury ion binding 1.85843060232985 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
glycosaminoglycan binding 1.56410665522466 bayes_pls_golite062009
myosin light chain kinase activity 1.49217960276915 bayes_pls_golite062009
protein kinase activity 1.42856560840953 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 1.27192437373177 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
growth hormone receptor activity 1.15929762138929 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.15899955607967 bayes_pls_golite062009
heparin binding 1.15000556789505 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.12142142875217 bayes_pls_golite062009
kinase activity 1.11027658115625 bayes_pls_golite062009
cytokine activity 1.09433218752101 bayes_pls_golite062009
structural molecule activity 0.94240190391222 bayes_pls_golite062009
peptide binding 0.92031154055894 bayes_pls_golite062009
interleukin-6 binding 0.888638861691021 bayes_pls_golite062009
interleukin-6 receptor activity 0.888638861691021 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
collagen binding 0.593745877718282 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
polysaccharide binding 0.54737137289904 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
cytokine receptor binding 0.47107517390107 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
pattern binding 0.44460010885883 bayes_pls_golite062009
growth factor activity 0.432629984792427 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
cell surface binding 0.366415248711076 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protease binding 0.12595904253108 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009
interleukin-11 receptor activity 0.0423783987133706 bayes_pls_golite062009
interleukin-11 binding 0.0423783987133706 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1405-1642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSPHVTLSAT TTDALTVKLK PHEGDTAPLH GYTLHYKPEF GEWETSEVSV DSQKHNIEGL  60
   61 LCGSRYQVYA TGFNNIGAGE ASDILNTRTK GQKPKLPEKP RFIEVSSNSV SLHFKAWKDG 120
  121 GCPMSHFVVE SKKRDQIEWN QISNNVKPDN NYVVLDLEPA TWYNLRITAH NSAGFTVAEY 180
  181 DFATLTVTGG TIAPSRDLPE LSAEDTIRII LSNLNLVVPV VAALLVIIIA IIVICILR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1mfnA
Description: SOLUTION NMR STRUCTURE OF LINKED CELL ATTACHMENT MODULES OF MOUSE FIBRONECTIN CONTAINING THE RGD AND SYNERGY REGIONS, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
transmembrane receptor activity 4.81256300373074 bayes_pls_golite062009
ankyrin binding 4.69755754047169 bayes_pls_golite062009
receptor activity 4.66147271961356 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
cytokine binding 4.43581512268554 bayes_pls_golite062009
cytokine receptor activity 4.08668869714207 bayes_pls_golite062009
growth factor binding 4.06808996928726 bayes_pls_golite062009
molecular transducer activity 3.69234048247377 bayes_pls_golite062009
signal transducer activity 3.69234048247377 bayes_pls_golite062009
extracellular matrix structural constituent 3.5949595622742 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
receptor binding 2.38673889309915 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
peptide hormone binding 2.12033076929638 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
mercury ion binding 1.85843060232985 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
glycosaminoglycan binding 1.56410665522466 bayes_pls_golite062009
myosin light chain kinase activity 1.49217960276915 bayes_pls_golite062009
protein kinase activity 1.42856560840953 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 1.27192437373177 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
growth hormone receptor activity 1.15929762138929 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.15899955607967 bayes_pls_golite062009
heparin binding 1.15000556789505 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.12142142875217 bayes_pls_golite062009
kinase activity 1.11027658115625 bayes_pls_golite062009
cytokine activity 1.09433218752101 bayes_pls_golite062009
structural molecule activity 0.94240190391222 bayes_pls_golite062009
peptide binding 0.92031154055894 bayes_pls_golite062009
interleukin-6 binding 0.888638861691021 bayes_pls_golite062009
interleukin-6 receptor activity 0.888638861691021 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
collagen binding 0.593745877718282 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
polysaccharide binding 0.54737137289904 bayes_pls_golite062009
hormone binding 0.49524185948356 bayes_pls_golite062009
cytokine receptor binding 0.47107517390107 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
pattern binding 0.44460010885883 bayes_pls_golite062009
growth factor activity 0.432629984792427 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
cell surface binding 0.366415248711076 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protease binding 0.12595904253108 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009
interleukin-11 receptor activity 0.0423783987133706 bayes_pls_golite062009
interleukin-11 binding 0.0423783987133706 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1643-1864]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKGNHHKDDV VYNQTMGPGA TLDKRRPDLR DELGYIAPPN RKLPPVPGSN YNTCDRIKRG  60
   61 RGGLRSNHST WDPRRNPNLY EELKAPPVPM HGNHYGHAHG NAECHYRHPG MEDEICPYAT 120
  121 FHLLGFREEM DPTKAMNFQT FPHQNGHAGP VPGHAGTMLP PGHPGHVHSR SGSQSMPRAN 180
  181 RYQRKNSQGG QSSIYTPAPE YDDPANCAEE DQYRRYTRVN SQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1865-2017]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGSLYSGPGP EYDDPANCAP EEDQYGSQYG GPYGQPYDHY GSRGSMGRRS IGSARNPGNG  60
   61 SPEPPPPPPR NHDMSNSSFN DSKESNEISE AECDRDHGPR GNYGAVKRSP QPKDQRTTEE 120
  121 MRKLIERNET GPKQLQLQQA NGAGFTAYDT MAV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle