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Protein Overview: Dscam-PM

General Information:
Name(s) found: Dscam-PM / FBpp0110382 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2017 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVSQH YEEDIHKAFV IRGNSAILKC DIPSFVADFV NVISWHSDEK 180
  181 ENFYPGTEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSVQPKIS VGERRKDAEV PKHGDLSIFC PAQSYPVPAF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMVPPQ IQAFDFGSEA ANTGEMAGGF CMVPKGDLPM EIRWTLNSAP 660
  661 IITGEHGFSL SRLNPRTSSL SIDSLEARHR GLYRCIASNK AGSAEYSAEL HVNVPPRWIL 720
  721 EPTDKAFAQG SDAKVECKAD GFPKPQVTWK KAVGDTPGEY KDLKKSDNIR VEEGTLHVDN 780
  781 IQKTNEGYYL CEAINGIGSG LSAVIMISVQ APPEFTEKLR NQTARRGEPA VLQCEAKGEK 840
  841 PIGILWNMNN MRLDPKNDNR YTIREEILST GVMSSLSIKR TERSDSALFT CVATNAFGSD 900
  901 DASINMIVQE VPEMPYALKV LDKSGRSVQL SWAQPYDGNS PLDRYIIEFK RSRASWSEID 960
  961 RVIVPGHTTE AQVQKLSPAT TYNIRIVAEN AIGTSQSSEA VTIITAEEAP SGKPQNIKVE1020
 1021 PVNQTTMRVT WKPPPRTEWN GEILGYYVGY KLSNTNSSYV FETINFITEE GKEHNLELQN1080
 1081 LRVYTQYSVV IQAFNKIGAG PLSEEEKQFT AEGTPSQPPS DTACTTLTSQ TIRVGWVSPP1140
 1141 LESANGVIKT YKVVYAPSDE WYDETKRHYK KTASSDTVLH GLKKYTNYTM QVLATTAGGD1200
 1201 GVRSVPIHCQ TEPDVPEAPT DVKALVMGNA AILVSWRPPA QPNGIITQYT VYSKAEGAET1260
 1261 ETKTQKVPHY QMSFEATELE KNKPYEFWVT ASTTIGEGQQ SKSIVAMPSD QVPAKIASFD1320
 1321 DTFTATFKED AKMPCLAVGA PQPEITWKIK GVEFSANDRM RVLPDGSLLI KSVNRQDAGD1380
 1381 YSCHAENSIA KDSITHKLIV LAPPQSPHVT LSATTTDALT VKLKPHEGDT APLHGYTLHY1440
 1441 KPEFGEWETS EVSVDSQKHN IEGLLCGSRY QVYATGFNNI GAGEASDILN TRTKGQKPKL1500
 1501 PEKPRFIEVS SNSVSLHFKA WKDGGCPMSH FVVESKKRDQ IEWNQISNNV KPDNNYVVLD1560
 1561 LEPATWYNLR ITAHNSAGFT VAEYDFATLT VTGGTIAPSR DLPELSAEDT IRIILSNLNL1620
 1621 VVPVVAALLV IIIAIIVICI LRSKGNHHKD DVVYNQTMGP GATLDKRRPD LRDELGYIAP1680
 1681 PNRKLPPVPG SNYNTCDRIK RGRGGLRSNH STWDPRRNPN LYEELKAPPV PMHGNHYGHA1740
 1741 HGNAECHYRH PGMEDEICPY ATFHLLGFRE EMDPTKAMNF QTFPHQNGHA GPVPGHAGTM1800
 1801 LPPGHPGHVH SRSGSQSMPR ANRYQRKNSQ GGQSSIYTPA PEYDDPANCA EEDQYRRYTR1860
 1861 VNSQGGSLYS GPGPEYDDPA NCAPEEDQYG SQYGGPYGQP YDHYGSRGSM GRRSIGSARN1920
 1921 PGNGSPEPPP PPPRNHDMSN SSFNDSKESN EISEAECDRD HGPRGNYGAV KRSPQPKDQR1980
 1981 TTEEMRKLIE RNETGPKQLQ LQQANGAGFT AYDTMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] PSI-BLAST 80.0 No description for 2v5sA was found.
    2 View Details [139..604] PSI-BLAST 53.045757 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    3 View Details [605..1307] PSI-BLAST 15.69897 No description for 2dtgE was found.
    4 View Details [1308..1391] PSI-BLAST 28.154902 No description for 2v5yA was found.
    5 View Details [1392..1595] PSI-BLAST 9.69897 No description for 2ibgA was found.
    6 View Details [1596..1821] deduced N/A No confident structure predictions are available.
    7 View Details [1822..2017] MSA 3.127991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • growth factor binding
    		•  6.33296746316446 bayes_pls_golite062009
  • telethonin binding
    		•  5.81747667416248 bayes_pls_golite062009
  • structural constituent of muscle
    		•  5.71979489668015 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  5.09204037654114 bayes_pls_golite062009
  • ankyrin binding
    		•  4.69755754047169 bayes_pls_golite062009
  • alpha-actinin binding
    		•  4.57951951779666 bayes_pls_golite062009
  • actinin binding
    		•  4.57900103206288 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • cytokine receptor activity
    		•  4.08668869714207 bayes_pls_golite062009
  • insulin-like growth factor I binding
    		•  3.14198260332974 bayes_pls_golite062009
  • binding
    		•  3.10942625145915 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  3.09281229196379 bayes_pls_golite062009
  • protein binding
    		•  3.04595153576805 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  2.35038076333169 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.11274485218746 bayes_pls_golite062009
  • receptor activity
    		•  2.04770371945982 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • prolactin receptor activity
    		•  1.9556649101819 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • signal transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64316913174221 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.50579173120225 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.49217960276915 bayes_pls_golite062009
  • collagen binding
    		•  1.4103164804739 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.3823186140816 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.36671598599873 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.35826958219514 bayes_pls_golite062009
  • kinase activity
    		•  1.33897988039058 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.32223335106618 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31663344632755 bayes_pls_golite062009
  • phosphatase activator activity
    		•  1.23699452328993 bayes_pls_golite062009
  • actin binding
    		•  1.21726363067325 bayes_pls_golite062009
  • DNA binding
    		•  1.2006039770643 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.17568458983071 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.17332908979699 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  1.15929762138929 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  1.07748328484506 bayes_pls_golite062009
  • cell surface binding
    		•  1.05599555585797 bayes_pls_golite062009
  • interleukin-6 binding
    		•  0.888638861691021 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  0.888638861691021 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • transferase activity
    		•  0.694193657141457 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.628488391922279 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.628488391922279 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.626982547776451 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.625443680166071 bayes_pls_golite062009
  • structural molecule activity
    		•  0.611417906910562 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.5845342946602 bayes_pls_golite062009
  • transcription factor activity
    		•  0.557290274937694 bayes_pls_golite062009
  • phosphatase binding
    		•  0.479382571752751 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.46177345987477 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.430075899423884 bayes_pls_golite062009
  • protein-hormone receptor activity
    		•  0.42902267001067 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.41080910982871 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.40600177052491 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • receptor binding
    		•  0.319201203357304 bayes_pls_golite062009
  • interleukin-7 binding
    		•  0.301052531308189 bayes_pls_golite062009
  • catalytic activity
    		•  0.271811389148807 bayes_pls_golite062009
  • pattern binding
    		•  0.195655028782749 bayes_pls_golite062009
  • actin filament binding
    		•  0.142821832073786 bayes_pls_golite062009
  • transcription activator activity
    		•  0.135753557343301 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.126307392530805 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • transcription factor binding
    		•  0.075900818564989 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0323918145169712 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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