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View Structure Prediction Details

Protein: eag-PB
Organism: Drosophila melanogaster
Length: 1270 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eag-PB.

Description E-value Query
Range		 Subject
Range
eag-PA - The gene ether a go-go is referred to in FlyBase by the symbol Dmel\eag (CG10952, FBgn0000535). It i...
 678.0 [0..1] [741..1]

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Predicted Domain #1
Region A:
Residues: [1-158] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGGRRGLVA PQNTFLENII RRSNSQPDSS FLLANAQIVD FPIVYCNESF CKISGYNRAE  60
   61 VMQKSCRYVC GFMYGELTDK ETVGRLEYTL ENQQQDQFEI LLYKKNNLQC GCALSQFGKA 120
  121 QTQETPLWLL LQVAPIRNER DLVVLFLLTF RDITALKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1bywA
Description: Erg potassium channel, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.00739782551896 bayes_pls_golite062009
gated channel activity 1.91690893235943 bayes_pls_golite062009
cation channel activity 1.83585463250341 bayes_pls_golite062009
ion channel activity 1.81480748017981 bayes_pls_golite062009
substrate-specific channel activity 1.79917026180833 bayes_pls_golite062009
passive transmembrane transporter activity 1.79789317069635 bayes_pls_golite062009
channel activity 1.79789317069635 bayes_pls_golite062009
protein binding 1.71247140566473 bayes_pls_golite062009
voltage-gated cation channel activity 1.3470145987992 bayes_pls_golite062009
voltage-gated ion channel activity 1.27432373887655 bayes_pls_golite062009
voltage-gated channel activity 1.2665899543283 bayes_pls_golite062009
voltage-gated potassium channel activity 1.00645229414859 bayes_pls_golite062009
potassium channel activity 0.9406856741777 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.94001632754206 bayes_pls_golite062009
protein heterodimerization activity 0.616083539456994 bayes_pls_golite062009
cation transmembrane transporter activity 0.54764921045878 bayes_pls_golite062009
protein dimerization activity 0.540317215341062 bayes_pls_golite062009
ion transmembrane transporter activity 0.52554527212024 bayes_pls_golite062009
DNA binding 0.501185415738505 bayes_pls_golite062009
nucleic acid binding 0.342849434354421 bayes_pls_golite062009
substrate-specific transporter activity 0.240313694627417 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.22397174724003 bayes_pls_golite062009
signal transducer activity 0.208344826438381 bayes_pls_golite062009
molecular transducer activity 0.208344826438381 bayes_pls_golite062009
transcription factor binding 0.169995526319237 bayes_pls_golite062009
ligand-gated ion channel activity 0.12269112314479 bayes_pls_golite062009
ligand-gated channel activity 0.12269112314479 bayes_pls_golite062009
receptor binding 0.10219368123436 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.0409239477620129 bayes_pls_golite062009
transcription factor activity 0.0149060162978822 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [159-221] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIDSEDTKGV LGLSKFAKLA RSVTRSRQFS AHLPTLKDPT KQSNLAHMMS LSADIMPQYR  60
   61 QEA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [222-502] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKTPPHILLH YCAFKAIWDW VILCLTFYTA IMVPYNVAFK NKTSEDVSLL VVDSIVDVIF  60
   61 FIDIVLNFHT TFVGPGGEVV SDPKVIRMNY LKSWFIIDLL SCLPYDVFNA FDRDEDGIGS 120
  121 LFSALKVVRL LRLGRVVRKL DRYLEYGAAM LILLLCFYML VAHWLACIWY SIGRSDADNG 180
  181 IQYSWLWKLA NVTQSPYSYI WSNDTGPELV NGPSRKSMYV TALYFTMTCM TSVGFGNVAA 240
  241 ETDNEKVFTI CMMIIAALLY ATIFGHVTTI IQQMTSATAK Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.154902
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [503-749] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDMLNNVREF MKLHEVPKAL SERVMDYVVS TWAMTKGLDT EKVLNYCPKD MKADICVHLN  60
   61 RKVFNEHPAF RLASDGCLRA LAMHFMMSHS APGDLLYHTG ESIDSLCFIV TGSLEVIQDD 120
  121 EVVAILGKGD VFGDQFWKDS AVGQSAANVR ALTYCDLHAI KRDKLLEVLD FYSAFANSFA 180
  181 RNLVLTYNLR HRLIFRKVAD VKREKELAER RKNEPQLPQN QDHLVRKIFS KFRRTPQVQA 240
  241 GSKELVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.522879
Match: 1q3eA
Description: HCN2J 443-645 in the presence of cGMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic nucleotide-gated ion channel activity 9.28636958853471 bayes_pls_golite062009
intracellular cyclic nucleotide activated cation channel activity 9.28636958853471 bayes_pls_golite062009
intracellular cGMP activated cation channel activity 9.19973076787954 bayes_pls_golite062009
cGMP binding 7.7575871125398 bayes_pls_golite062009
cyclic nucleotide binding 7.37322432929433 bayes_pls_golite062009
GMP binding 5.49455172024846 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 5.41338975259319 bayes_pls_golite062009
ion channel activity 3.49583875363169 bayes_pls_golite062009
substrate-specific channel activity 3.47594979516506 bayes_pls_golite062009
channel activity 3.47292007271524 bayes_pls_golite062009
passive transmembrane transporter activity 3.47292007271524 bayes_pls_golite062009
gated channel activity 3.37377842331303 bayes_pls_golite062009
ligand-gated ion channel activity 3.37179273893244 bayes_pls_golite062009
ligand-gated channel activity 3.37179273893244 bayes_pls_golite062009
cation channel activity 3.21018655666175 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.28757379242869 bayes_pls_golite062009
ion transmembrane transporter activity 2.09857147539905 bayes_pls_golite062009
cation transmembrane transporter activity 1.83682117020899 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.75627200599162 bayes_pls_golite062009
substrate-specific transporter activity 1.73592246548483 bayes_pls_golite062009
transporter activity 1.35258517502962 bayes_pls_golite062009
binding 1.10631659705555 bayes_pls_golite062009
protein binding 0.79369425144072 bayes_pls_golite062009
transmembrane transporter activity 0.0813383312287812 bayes_pls_golite062009
voltage-gated ion channel activity 0.0547320132152402 bayes_pls_golite062009
voltage-gated channel activity 0.0476232921116697 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [750-827] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSGQSDVEKG DGEVERTKLP AKLTLTEDAR ILSTAAAPSP SPSPSPSSGP PSARSTRASK  60
   61 WGRLLGSSSV DSASDTSA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [828-1270] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVAVSRSLSA RESLRESTAQ ARQSSTSSSN GGQGNKVFPK APKLQASQAT LARQDTIDEG  60
   61 GEVDSSPPSR DSRVVIEGAA VSSATVGPSP PVATTSSAAA GAGVSGGPGS GGTVVAIVTK 120
  121 ADRNLALERE RQIEMASSRA TTSDTYDTGL RETPPTLAQR DLIATVLDMK VDVRLELQRM 180
  181 QQRIGRIEDL LGELVKRLAP GAGSGGNAPD NSSGQTTPGD EICAGCGAGG GGTPTTQAPP 240
  241 TSAVTSPVDT VITISSPGAS GSGSGTGAGA GSAVAGAGGA GLLNPGATVV SSAGGNGLGP 300
  301 LMLKKRRSKS RKAPAPPKQT LASTAGTATA APAGVAGSGM TSSAPASADQ QQQHQSTADQ 360
  361 SPTTPGAELL HLRLLEEDFT AAQLPSTSSG GAGGGGGSGS GATPTTPPPT TAGGSGSGTP 420
  421 TSTTATTTPT GSGTATRGKL DFL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.69897
Match: 1y0fB
Description: No description for 1y0fB was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle