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Protein Overview: eag-PB

General Information:
Name(s) found: eag-PB / FBpp0110308 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene ether a go-go is referred to in FlyBase by the symbol Dmel\eag (CG10952, FBgn0000535). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14865289..14899359. It has the cytological map location 13A2-13A5. There is experimental evidence that it has the molecular function</span>: voltage-gated cation channel activity. There is experimental evidence that it is involved in the biological process</span>: perineurial glial growth; learning or memory; flight behavior. 21 alleles are reported. The phenotypes of these alleles are annotated with: leg; neuromuscular junction; synapse; adult brain. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1270 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGGRRGLVA PQNTFLENII RRSNSQPDSS FLLANAQIVD FPIVYCNESF CKISGYNRAE  60
   61 VMQKSCRYVC GFMYGELTDK ETVGRLEYTL ENQQQDQFEI LLYKKNNLQC GCALSQFGKA 120
  121 QTQETPLWLL LQVAPIRNER DLVVLFLLTF RDITALKQPI DSEDTKGVLG LSKFAKLARS 180
  181 VTRSRQFSAH LPTLKDPTKQ SNLAHMMSLS ADIMPQYRQE APKTPPHILL HYCAFKAIWD 240
  241 WVILCLTFYT AIMVPYNVAF KNKTSEDVSL LVVDSIVDVI FFIDIVLNFH TTFVGPGGEV 300
  301 VSDPKVIRMN YLKSWFIIDL LSCLPYDVFN AFDRDEDGIG SLFSALKVVR LLRLGRVVRK 360
  361 LDRYLEYGAA MLILLLCFYM LVAHWLACIW YSIGRSDADN GIQYSWLWKL ANVTQSPYSY 420
  421 IWSNDTGPEL VNGPSRKSMY VTALYFTMTC MTSVGFGNVA AETDNEKVFT ICMMIIAALL 480
  481 YATIFGHVTT IIQQMTSATA KYHDMLNNVR EFMKLHEVPK ALSERVMDYV VSTWAMTKGL 540
  541 DTEKVLNYCP KDMKADICVH LNRKVFNEHP AFRLASDGCL RALAMHFMMS HSAPGDLLYH 600
  601 TGESIDSLCF IVTGSLEVIQ DDEVVAILGK GDVFGDQFWK DSAVGQSAAN VRALTYCDLH 660
  661 AIKRDKLLEV LDFYSAFANS FARNLVLTYN LRHRLIFRKV ADVKREKELA ERRKNEPQLP 720
  721 QNQDHLVRKI FSKFRRTPQV QAGSKELVGG SGQSDVEKGD GEVERTKLPA KLTLTEDARI 780
  781 LSTAAAPSPS PSPSPSSGPP SARSTRASKW GRLLGSSSVD SASDTSAKVA VSRSLSARES 840
  841 LRESTAQARQ SSTSSSNGGQ GNKVFPKAPK LQASQATLAR QDTIDEGGEV DSSPPSRDSR 900
  901 VVIEGAAVSS ATVGPSPPVA TTSSAAAGAG VSGGPGSGGT VVAIVTKADR NLALERERQI 960
  961 EMASSRATTS DTYDTGLRET PPTLAQRDLI ATVLDMKVDV RLELQRMQQR IGRIEDLLGE1020
 1021 LVKRLAPGAG SGGNAPDNSS GQTTPGDEIC AGCGAGGGGT PTTQAPPTSA VTSPVDTVIT1080
 1081 ISSPGASGSG SGTGAGAGSA VAGAGGAGLL NPGATVVSSA GGNGLGPLML KKRRSKSRKA1140
 1141 PAPPKQTLAS TAGTATAAPA GVAGSGMTSS APASADQQQQ HQSTADQSPT TPGAELLHLR1200
 1201 LLEEDFTAAQ LPSTSSGGAG GGGGSGSGAT PTTPPPTTAG GSGSGTPTST TATTTPTGSG1260
 1261 TATRGKLDFL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] PSI-BLAST 21.0 Erg potassium channel, N-terminal domain
    2 View Details [159..221] deduced N/A No confident structure predictions are available.
    3 View Details [222..502] PSI-BLAST 13.154902 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    4 View Details [503..749] PSI-BLAST 48.522879 HCN2J 443-645 in the presence of cGMP
    5 View Details [750..827] deduced N/A No confident structure predictions are available.
    6 View Details [828..1270] PSI-BLAST 55.69897 No description for 1y0fB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.00739782551896 bayes_pls_golite062009
  • gated channel activity
    		•  1.91690893235943 bayes_pls_golite062009
  • cation channel activity
    		•  1.83585463250341 bayes_pls_golite062009
  • ion channel activity
    		•  1.81480748017981 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.79917026180833 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.79789317069635 bayes_pls_golite062009
  • channel activity
    		•  1.79789317069635 bayes_pls_golite062009
  • protein binding
    		•  1.71247140566473 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.3470145987992 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  1.27432373887655 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  1.2665899543283 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  1.00645229414859 bayes_pls_golite062009
  • potassium channel activity
    		•  0.9406856741777 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.94001632754206 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.616083539456994 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.54764921045878 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.540317215341062 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.52554527212024 bayes_pls_golite062009
  • DNA binding
    		•  0.501185415738505 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.342849434354421 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.240313694627417 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.22397174724003 bayes_pls_golite062009
  • signal transducer activity
    		•  0.208344826438381 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.208344826438381 bayes_pls_golite062009
  • transcription factor binding
    		•  0.169995526319237 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.12269112314479 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.12269112314479 bayes_pls_golite062009
  • receptor binding
    		•  0.10219368123436 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.0409239477620129 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0149060162978822 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • cyclic nucleotide-gated ion channel activity
    		•  9.28636958853471 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  9.28636958853471 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  5.41338975259319 bayes_pls_golite062009
  • ion channel activity
    		•  3.49583875363169 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  3.47594979516506 bayes_pls_golite062009
  • channel activity
    		•  3.47292007271524 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  3.47292007271524 bayes_pls_golite062009
  • gated channel activity
    		•  3.37377842331303 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.37179273893244 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.37179273893244 bayes_pls_golite062009
  • cation channel activity
    		•  3.21018655666175 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.28757379242869 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.09857147539905 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.83682117020899 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.75627200599162 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.73592246548483 bayes_pls_golite062009
  • transporter activity
    		•  1.35258517502962 bayes_pls_golite062009
  • binding
    		•  1.10631659705555 bayes_pls_golite062009
  • protein binding
    		•  0.79369425144072 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.0813383312287812 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.0547320132152402 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.0476232921116697 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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