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View Structure Prediction Details

Protein: gi|3327040
Organism: Homo sapiens
Length: 734 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|3327040.

Description E-value Query
Range		 Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
 0.0 [82..728] [2241..2882]
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
 0.0 [27..732] [531..1231]
gi|109125970 - gi|109125970|ref|XP_001115785.1| PREDICTED: similar to zinc finger protein 665 [Macaca mulatta]
 0.0 [236..726] [251..738]
gi|109485628, gi... - gi|109485628|ref|XP_001078438.1| PREDICTED: similar to zinc finger protein ZFP isoform 1 [Rattus nor...
 0.0 [98..733] [536..1162]

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Predicted Domain #1
Region A:
Residues: [1-69] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAADSTSMSY SVTLTGPGPW GFRLQGGKDF NMPLTISRIT PGSKAAQSQL SQGDLVVAID  60
   61 GVNTDTMTH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.221849
Match: 1rgwA
Description: Solution Structure of ZASP's PDZ domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.60106431937699 bayes_pls_golite062009
structural constituent of muscle 3.0482783169186 bayes_pls_golite062009
actinin binding 2.91261541242779 bayes_pls_golite062009
binding 2.6316969452405 bayes_pls_golite062009
protein binding 2.25893018754605 bayes_pls_golite062009
actin binding 2.13642404399707 bayes_pls_golite062009
transporter activity 0.782216866213126 bayes_pls_golite062009
transmembrane transporter activity 0.699604120098573 bayes_pls_golite062009
PDZ domain binding 0.53069705861477 bayes_pls_golite062009
substrate-specific transporter activity 0.434921764966531 bayes_pls_golite062009
actin filament binding 0.395248867755308 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.250590541549843 bayes_pls_golite062009
structural constituent of cytoskeleton 0.182094987832726 bayes_pls_golite062009
protein domain specific binding 0.15766709142367 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [70-157] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEAQNKIKSA SYNLSLTLQK SKRPIPISTT APPVQTPLPV IPHQKDPALD TNGSLVAPSP  60
   61 SPEARASPGT PGTPELRPTF SPAFSRPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [158-241] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AFSSLAEASD PGPPRASLRA KTSPEGARDL LGPKALPGSS QPRQYNNPIG LYSAETLREM  60
   61 AQMYQMSLRG KASGVGLPGG SLPI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [242-299] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDLAVDSASP VYQAVIKSQN KPEDEADEWA RRSSNLQSRS FRILAQMTGT EFMQDPDE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [300-414] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EALRRSSTPI EHAPVCTSQA TTPLLPASAQ PPAAASPSAA SPPLATAAAH TAIASASTTA  60
   61 PASSPADSPR PQASSYSPAV AASSAPATHT SYSEGPAAPA PKPRVVTTAS IRPSV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [415-491] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQPVPASTYS PSPGANYSPT PYTPSPAPAY TPSPAPAYTP SPVPTYTPSP APAYTPSPAP  60
   61 NYNPAPSVAY SGGPAEP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.14
Match: 1q1qA
Description: Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transporter activity 2.52497552014278 bayes_pls_golite062009
transmembrane transporter activity 2.40658013079084 bayes_pls_golite062009
cytoskeletal protein binding 2.39214016658615 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.35708720741144 bayes_pls_golite062009
pyrophosphatase activity 2.28572270826306 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.2679790267601 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.26439443616623 bayes_pls_golite062009
primary active transmembrane transporter activity 2.08046022919779 bayes_pls_golite062009
motor activity 2.07772440476994 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.07687836248701 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.03985463174903 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.03554410262972 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.03501965794966 bayes_pls_golite062009
active transmembrane transporter activity 1.96755553127373 bayes_pls_golite062009
binding 1.95375255800529 bayes_pls_golite062009
ATPase activity 1.90719478261095 bayes_pls_golite062009
ATPase activity, coupled 1.89951058094584 bayes_pls_golite062009
actin binding 1.73490290591968 bayes_pls_golite062009
substrate-specific transporter activity 1.48825800569252 bayes_pls_golite062009
structural constituent of muscle 1.35085869260647 bayes_pls_golite062009
microtubule motor activity 1.27318173398333 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.17138261833001 bayes_pls_golite062009
hydrolase activity 1.00498978255976 bayes_pls_golite062009
tubulin binding 0.820284115671881 bayes_pls_golite062009
microfilament motor activity 0.789128756960111 bayes_pls_golite062009
actin filament binding 0.68421152762816 bayes_pls_golite062009
ion transmembrane transporter activity 0.637621825415179 bayes_pls_golite062009
microtubule binding 0.634383883834603 bayes_pls_golite062009
GTPase activity 0.603004420222648 bayes_pls_golite062009
purine nucleotide binding 0.509855138537351 bayes_pls_golite062009
nucleotide binding 0.503649548307811 bayes_pls_golite062009
purine ribonucleotide binding 0.49583023878914 bayes_pls_golite062009
ribonucleotide binding 0.495817032502758 bayes_pls_golite062009
cation transmembrane transporter activity 0.249266001065856 bayes_pls_golite062009
guanyl nucleotide binding 0.16639805763162 bayes_pls_golite062009
GTP binding 0.163692554293628 bayes_pls_golite062009
guanyl ribonucleotide binding 0.160665710980295 bayes_pls_golite062009
protein binding 0.102043618157662 bayes_pls_golite062009
protein transporter activity 0.0840319419284095 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0197193998031486 bayes_pls_golite062009
ATP binding 0.00203463095479706 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [492-550] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASRPPWVTDD SFSQKFAPGK STTSISKQTL PRGGPAYTPA GPQVPPLARG TVQRAERFP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.47962305876847 bayes_pls_golite062009
cytoskeletal protein binding 2.22104591928521 bayes_pls_golite062009
DNA binding 2.00908648793732 bayes_pls_golite062009
nucleic acid binding 1.98196470793823 bayes_pls_golite062009
transcription regulator activity 1.92901308597163 bayes_pls_golite062009
transcription factor activity 1.10908190809074 bayes_pls_golite062009
protein binding 0.905022998164426 bayes_pls_golite062009
tubulin binding 0.744315484113484 bayes_pls_golite062009
microtubule binding 0.576452165256057 bayes_pls_golite062009
chromatin binding 0.44494725351897 bayes_pls_golite062009
transcription activator activity 0.28378358922747 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.27673489856581 bayes_pls_golite062009
signal transducer activity 0.0590340677124848 bayes_pls_golite062009
molecular transducer activity 0.0590340677124848 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [551-734] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASSRTPLCGH CNNVIRGPFL VAMGRSWHPE EFTCAYCKTS LADVCFVEEQ NNVYCERCYE  60
   61 QFFAPLCAKC NTKIMGEVMH ALRQTWHTTC FVCAACKKPF GNSLFHMEDG EPYCEKDYIN 120
  121 LFSTKCHGCD FPVEAGDKFI EALGHTWHDT CFICAVCHVN LEGQPFYSKK DRPLCKKHAH 180
  181 TINL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.522879
Match: 2i13A
Description: No description for 2i13A was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle