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View Structure Prediction Details

Protein: SCYL1
Organism: Homo sapiens
Length: 808 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SCYL1.

Description E-value Query
Range		 Subject
Range
gi|115430243, gi... - gi|14041817|dbj|BAB55459.1| kinase-like protein splice variant 1 [Homo sapiens], gi|119594802|gb|EAW...
 7.0E-76 [1..808] [1..791]
gi|109105494 - gi|109105494|ref|XP_001113724.1| PREDICTED: similar to SCY1-like 1 isoform 3 [Macaca mulatta]
 3.0E-73 [1..808] [1..803]
gi|21961588 - gi|21961588|gb|AAH34519.1| SCY1-like 1 (S. cerevisiae) [Mus musculus]
 2.0E-72 [1..808] [1..806]
NTKL_RAT - N-terminal kinase-like protein OS=Rattus norvegicus GN=Scyl1 PE=2 SV=1
 6.0E-71 [1..808] [1..807]
gi|76658146, gi|... - gi|76658146|ref|XP_887593.1| PREDICTED: similar to SCY1-like 1 isoform 6 [Bos taurus], gi|119919263|...
 1.0E-67 [1..808] [1..807]

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Predicted Domain #1
Region A:
Residues: [1-443] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV KPGAEEQTQV  60
   61 AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG IYLKARVEAG GLKELEISWG 120
  121 LHQIVKALSF LVNDCSLIHN NVCMAAVFVD RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE 180
  181 LEQYDPPELA DSSGRVVREK WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY 240
  241 CELVGANPKV RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 300
  301 LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI IPVVVKMFSS 360
  361 TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT NPAIREQTVK SMLLLAPKLN 420
  421 EANLNVELMK HFARLQAKDE QGP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.69897
Match: 1omwA
Description: G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.86908674572736 bayes_pls_golite062009
protein binding 1.62406684925162 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.52597476013849 bayes_pls_golite062009
kinase activity 1.46967868776426 bayes_pls_golite062009
protein kinase activity 1.42061676948467 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.35441545960336 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
clathrin binding 1.03004613836485 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
protein serine/threonine kinase activity 0.940749450143365 bayes_pls_golite062009
transferase activity 0.876865688160088 bayes_pls_golite062009
ATP binding 0.80100967388643 bayes_pls_golite062009
adenyl ribonucleotide binding 0.766575848955892 bayes_pls_golite062009
adenyl nucleotide binding 0.755570176026019 bayes_pls_golite062009
purine ribonucleotide binding 0.718880569902791 bayes_pls_golite062009
ribonucleotide binding 0.718820382381459 bayes_pls_golite062009
purine nucleotide binding 0.715416129764882 bayes_pls_golite062009
nucleotide binding 0.708369770220977 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
catalytic activity 0.673946834085468 bayes_pls_golite062009
transmembrane receptor activity 0.481715990485843 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein tyrosine kinase activity 0.41304985993342 bayes_pls_golite062009
receptor activity 0.410629036454271 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.38249298672027 bayes_pls_golite062009
signal transducer activity 0.151379538173622 bayes_pls_golite062009
molecular transducer activity 0.151379538173622 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.0031825456963297 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [444-564] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRCNTTVCLG KIGSYLSAST RHRVLTSAFS RATRDPFAPS RVAGVLGFAA THNLYSMNDC  60
   61 AQKILPVLCG LTVDPEKSVR DQAFKAIRSF LSKLESVSED PTQLEEVEKD VHAASSPGMG 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.44
Match: 2ie3A
Description: No description for 2ie3A was found.

Predicted functions:

Term Confidence Notes
protein transporter activity 3.54751411727402 bayes_pls_golite062009
clathrin binding 3.06219301699422 bayes_pls_golite062009
transporter activity 2.3766833486706 bayes_pls_golite062009
substrate-specific transporter activity 2.12926593993985 bayes_pls_golite062009
binding 2.08129940242136 bayes_pls_golite062009
protein binding 2.0097220759196 bayes_pls_golite062009
transmembrane transporter activity 1.2724388835449 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.04982314606251 bayes_pls_golite062009
protein transmembrane transporter activity 0.440086981303253 bayes_pls_golite062009
active transmembrane transporter activity 0.260663498540354 bayes_pls_golite062009
ion transmembrane transporter activity 0.256036243669218 bayes_pls_golite062009
primary active transmembrane transporter activity 0.234271600707329 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.225395946682209 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.186601655036333 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.183072614802483 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.182751938544977 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.109435859778099 bayes_pls_golite062009
pyrophosphatase activity 0.0728493557966827 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0641324729536009 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0615190129942244 bayes_pls_golite062009
cation transmembrane transporter activity 0.0475280280823402 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [565-808] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAASWAGWAV TGVSSLTSKL IRSHPTTAPT ETNIPQRPTP EGVPAPAPTP VPATPTTSGH  60
   61 WETQEEDKDT AEDSSTADRW DDEDWGSLEQ EAESVLAQQD DWSTGGQVSR ASQVSNSDHK 120
  121 SSKSPESDWS SWEAEGSWEQ GWQEPSSQEP PPDGTRLASE YNWGGPESSD KGDPFATLSA 180
  181 RPSTQPRPDS WGEDNWEGLE TDSRQVKAEL ARKKREERRR EMEAKRAERK VAKGPMKLGA 240
  241 RKLD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle