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View Structure Prediction Details

Protein: CPA2
Organism: Homo sapiens
Length: 417 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPA2.

Description E-value Query
Range
Subject
Range
gi|114615933 - gi|114615933|ref|XP_001156440.1| PREDICTED: carboxypeptidase A2 (pancreatic) [Pan troglodytes]
0.0 [1..417] [1..417]
gi|30583645, gi|... - gi|30583645|gb|AAP36067.1| carboxypeptidase A2 (pancreatic) [Homo sapiens], gi|13937815|gb|AAH07009....
gi|60656483, gi|... - gi|60656485|gb|AAX32806.1| carboxypeptidase A2 [synthetic construct], gi|60656483|gb|AAX32805.1| car...
0.0 [1..417] [1..417]
gi|30584205, gi|... - gi|60653443|gb|AAX29416.1| carboxypeptidase A2 [synthetic construct], gi|30584205|gb|AAP36351.1| Hom...
0.0 [1..417] [1..417]
gi|73975552 - gi|73975552|ref|XP_532425.2| PREDICTED: similar to Carboxypeptidase A2 precursor isoform 1 [Canis fa...
0.0 [1..417] [1..417]
CBPA2_MOUSE - Carboxypeptidase A2 OS=Mus musculus GN=Cpa2 PE=1 SV=1
0.0 [1..417] [1..417]
gi|50756017 - gi|50756017|ref|XP_414978.1| PREDICTED: similar to Carboxypeptidase A2 precursor [Gallus gallus]
0.0 [1..417] [146..564]
CBPA2_RAT - Carboxypeptidase A2 OS=Rattus norvegicus GN=Cpa2 PE=1 SV=1
0.0 [1..417] [1..417]
CBPA1_PIG - Carboxypeptidase A1 OS=Sus scrofa GN=CPA1 PE=1 SV=2
0.0 [1..417] [1..419]

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Predicted Domain #1
Region A:
Residues: [1-417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLILFFGAL FGHIYCLETF VGDQVLEIVP SNEEQIKNLL QLEAQEHLQL DFWKSPTTPG  60
   61 ETAHVRVPFV NVQAVKVFLE SQGIAYSIMI EDVQVLLDKE NEEMLFNRRR ERSGNFNFGA 120
  121 YHTLEEISQE MDNLVAEHPG LVSKVNIGSS FENRPMNVLK FSTGGDKPAI WLDAGIHARE 180
  181 WVTQATALWT ANKIVSDYGK DPSITSILDA LDIFLLPVTN PDGYVFSQTK NRMWRKTRSK 240
  241 VSGSLCVGVD PNRNWDAGFG GPGASSNPCS DSYHGPSANS EVEVKSIVDF IKSHGKVKAF 300
  301 ITLHSYSQLL MFPYGYKCTK LDDFDELSEV AQKAAQSLRS LHGTKYKVGP ICSVIYQASG 360
  361 GSIDWSYDYG IKYSFAFELR DTGRYGFLLP ARQILPTAEE TWLGLKAIME HVRDHPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 140.0
Match: 1ayeA
Description: HUMAN PROCARBOXYPEPTIDASE A2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.786910294594 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.40766568731738 bayes_pls_golite062009
hydrolase activity 4.23257784904124 bayes_pls_golite062009
exopeptidase activity 3.28577934113028 bayes_pls_golite062009
metallopeptidase activity 2.76103081380105 bayes_pls_golite062009
carboxypeptidase activity 2.63658263814587 bayes_pls_golite062009
metalloexopeptidase activity 1.76058821499096 bayes_pls_golite062009
metallocarboxypeptidase activity 1.56827526553175 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
binding 1.18091528890016 bayes_pls_golite062009
endopeptidase activity 0.910234727191613 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.723243947871592 bayes_pls_golite062009
serine hydrolase activity 0.596149133958797 bayes_pls_golite062009
serine-type peptidase activity 0.578572340123331 bayes_pls_golite062009
nucleic acid binding 0.454707207494165 bayes_pls_golite062009
protein binding 0.215930537243465 bayes_pls_golite062009
DNA binding 0.115087846898245 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009
transcription regulator activity 0.0479880797560268 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle