YRC Public Data Repository - Protein Structure Prediction

Protein:	SEC63
Organism:	Homo sapiens
Length:	760 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC63.

Description	E-value	Query Range	Subject Range
gi\|73973969 - gi\|73973969\|ref\|XP_532252.2\| PREDICTED: similar to Translocation protein SEC63 homolog [Canis famili...	0.0	[4..742]	[94..832]
gi\|114608735 - gi\|114608735\|ref\|XP_001148185.1\| PREDICTED: SEC63-like protein isoform 4 [Pan troglodytes]	0.0	[1..742]	[1..742]
gi\|29387254 - gi\|29387254\|gb\|AAH48287.1\| SEC63 homolog (S. cerevisiae) [Homo sapiens]	0.0	[1..742]	[1..742]
SEC63_PONAB - Translocation protein SEC63 homolog OS=Pongo abelii GN=SEC63 PE=2 SV=1 SEC63_PONPY - Translocation protein SEC63 homolog - Pongo pygmaeus (Orangutan)	0.0	[1..742]	[1..743]
gi\|18476087 - gi\|18476087\|gb\|AAK00580.1\| SEC63 [Mus musculus]	0.0	[1..742]	[1..742]
gi\|34853169, gi\|... - gi\|34853169\|ref\|XP_228305.2\| PREDICTED: similar to Translocation protein SEC63 homolog [Rattus norve...	0.0	[1..742]	[1..742]
gi\|50744618 - gi\|50744618\|ref\|XP_419802.1\| PREDICTED: similar to Translocation protein SEC63 homolog [Gallus gallu...	0.0	[1..742]	[1..737]
gi\|109072243 - gi\|109072243\|ref\|XP_001092110.1\| PREDICTED: SEC63-like protein isoform 3 [Macaca mulatta] IPI:IPI00181825.... -	0.0	[1..742]	[1..709]

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Predicted Domain #1

Region A:
Residues: [1-99]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR KVYGRCMWYR  60
   61 LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDRE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [100-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQEYNPYEVL NLDPGATVAE IKKQYRLLSL KYHPDKGGDE VMFMRIAKAY AALTDEESRK  60
   61 NWEEFGNPDG PQATSFGIAL PAWIVDQKNS ILVLLVYGLA FMVILPVVVG SWWYRSIRYS 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.30103
Match:	1xblA
Description:	NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
signal recognition particle binding	4.18753628587547	bayes_pls_golite062009
ribonucleoprotein binding	2.20695097776982	bayes_pls_golite062009
protein binding	2.0077819170005	bayes_pls_golite062009
binding	1.75184008862922	bayes_pls_golite062009
transporter activity	1.29863098651348	bayes_pls_golite062009
protein transporter activity	0.939490372372376	bayes_pls_golite062009
unfolded protein binding	0.91241047562027	bayes_pls_golite062009
substrate-specific transporter activity	0.812144232432417	bayes_pls_golite062009
heat shock protein binding	0.796066295738949	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [220-497]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDQILIRTTQ IYTYFVYKTR NMDMKRLIMV LAGASEFDPQ YNKDATSRPT DNILIPQLIR  60
   61 EIGSINLKKN EPPLTCPYSL KARVLLLSHL ARMKIPETLE EDQQFMLKKC PALLQEMVNV 120
  121 ICQLIVMARN REEREFRAPT LASLENCMKL SQMAVQGLQQ FKSPLLQLPH IEEDNLRRVS 180
  181 NHKKYKIKTI QDLVSLKESD RHTLLHFLED EKYEEVMAVL GSFPYVTMDI KSQVLDDEDS 240
  241 NNITVGSLVT VLVKLTRQTM AEVFEKEQSI CAAEEQPA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	2q0zX
Description:	No description for 2q0zX was found.

Predicted functions:

Term	Confidence	Notes
ATPase activity, coupled	2.2162185402774	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.00003070639929	bayes_pls_golite062009
ATPase activity	1.94063929259701	bayes_pls_golite062009
pyrophosphatase activity	1.93031967085303	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.91231918357992	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.90999409453671	bayes_pls_golite062009
binding	1.0900341502935	bayes_pls_golite062009
hydrolase activity	0.863470202460548	bayes_pls_golite062009
protein binding	0.843450745288021	bayes_pls_golite062009
ATP-dependent helicase activity	0.223800319644873	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.223800319644873	bayes_pls_golite062009
catalytic activity	0.197884933993864	bayes_pls_golite062009
helicase activity	0.166899434976303	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.0561411188724552	bayes_pls_golite062009
RNA-dependent ATPase activity	0.0447036496272264	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [498-760]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDGQGETNKN RTKGGWQQKS KGPKKTAKSK KKKPLKKKPT PVLLPQSKQQ KQKQANGVVG  60
   61 NEAAVKEDEE EVSDKGSDSE EEETNRDSQS EKDDGSDRDS DREQDEKQNK DDEAEWQELQ 120
  121 QSIQRKERAL LETKSKITHP VYSLYFPEEK QEWWWLYIAD RKEQTLISMP YHVCTLKDTE 180
  181 EVELKFPAPG KPGNYQYTVF LRSDSYMGLD QIKPLKLEVH EAKPVPENHP QWDTAIEGDE 240
  241 DQEDSEGFED SFEEEEEEEE DDD

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.12
Match:	2q0zX
Description:	No description for 2q0zX was found.

Predicted functions:

Term	Confidence	Notes
ligand-gated channel activity	3.84815857667697	bayes_pls_golite062009
ligand-gated ion channel activity	3.84815857667697	bayes_pls_golite062009
transporter activity	2.35657262831396	bayes_pls_golite062009
transmembrane transporter activity	2.25147059981728	bayes_pls_golite062009
substrate-specific transporter activity	2.22751878261824	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.14804562881998	bayes_pls_golite062009
ion transmembrane transporter activity	2.08500207462933	bayes_pls_golite062009
cation transmembrane transporter activity	2.02275538762334	bayes_pls_golite062009
substrate-specific channel activity	1.98975215032128	bayes_pls_golite062009
channel activity	1.98765540246813	bayes_pls_golite062009
passive transmembrane transporter activity	1.98765540246813	bayes_pls_golite062009
voltage-gated cation channel activity	1.95683546055804	bayes_pls_golite062009
cation channel activity	1.93647351989637	bayes_pls_golite062009
potassium channel activity	1.90735237063729	bayes_pls_golite062009
ion channel activity	1.90734204729298	bayes_pls_golite062009
voltage-gated ion channel activity	1.89680019328623	bayes_pls_golite062009
voltage-gated channel activity	1.89163382477908	bayes_pls_golite062009
voltage-gated potassium channel activity	1.87377069780892	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.86336507935542	bayes_pls_golite062009
gated channel activity	1.80923664525859	bayes_pls_golite062009
protein binding	1.79910124244332	bayes_pls_golite062009
binding	1.71108326129383	bayes_pls_golite062009
inward rectifier potassium channel activity	1.30492997253657	bayes_pls_golite062009
cytoskeletal protein binding	0.405921935455161	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: