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View Structure Prediction Details

Protein: ESR1
Organism: Homo sapiens
Length: 595 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ESR1.

Description E-value Query
Range		 Subject
Range
gi|5702091 - gi|5702091|gb|AAD47137.1|AF061181_1 green fluorescent protein-estrogen receptor alpha fusion [Mammal...
 0.0 [4..595] [275..866]
gi|61367423 - gi|61367423|gb|AAX42995.1| estrogen receptor 1 [synthetic construct]
 0.0 [1..595] [1..595]
gi|72114, gi|216... - pir||QRHUE estrogen receptor 1 - human, ref|NP_000116.1| estrogen receptor 1 [Homo sapiens], gi|31...
 0.0 [1..595] [1..595]
gi|109072322 - gi|109072322|ref|XP_001097228.1| PREDICTED: estrogen receptor 1 [Macaca mulatta]
 0.0 [1..595] [1..595]
ESR1_BOVIN - Estrogen receptor OS=Bos taurus GN=ESR1 PE=1 SV=3
 0.0 [1..595] [1..596]
ESR1_FELCA - Estrogen receptor OS=Felis catus GN=ESR1 PE=2 SV=1
 0.0 [1..595] [1..595]
gi|2136499 - pir||I47140 estradiol receptor - pig
ESR1_PIG - Estrogen receptor OS=Sus scrofa GN=ESR1 PE=1 SV=1
 0.0 [1..595] [1..595]
ESR1_HORSE - Estrogen receptor OS=Equus caballus GN=ESR1 PE=2 SV=1
 0.0 [1..595] [1..594]
ESR1_MOUSE - Estrogen receptor OS=Mus musculus GN=Esr1 PE=1 SV=1
gi|189442821 - gi|189442821|gb|AAI67246.1| Estrogen receptor 1 (alpha) [synthetic construct]
 0.0 [1..595] [1..599]
gi|73945701 - gi|73945701|ref|XP_533454.2| PREDICTED: similar to Estrogen receptor (ER) (Estradiol receptor) (ER-a...
 0.0 [3..595] [1..596]

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Predicted Domain #1
Region A:
Residues: [1-101] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY  60
   61 EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL N

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 38.677781
Match: PF02159.6
Description: No description for PF02159.6 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.724 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.450 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.433 N/A N/A a.156.1 S13-like H2TH domain
View Download 0.361 N/A N/A a.77.1 DEATH domain
View Download 0.329 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains

Predicted Domain #2
Region A:
Residues: [102-177] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVSPSPLMLL HPPPQLSPFL QPHGQQVPYY LENEPSGYTV REAGPPAFYR PNSDNRRQGG  60
   61 RERLASTNDK GSMAME

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.974
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [178-279] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAKETRYCAV CNDYASGYHY GVWSCEGCKA FFKRSIQGHN DYMCPATNQC TIDKNRRKSC  60
   61 QACRLRKCYE VGMMKGGIRK DRRGGRMLKH KRQRDDGEGR GE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.0
Match: 1hcqA
Description: Estrogen receptor DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.55186574506963 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
steroid hormone receptor binding 2.19264900659739 bayes_pls_golite062009
androgen receptor binding 1.92232680714675 bayes_pls_golite062009
nuclear hormone receptor binding 1.91348392022358 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
molecular transducer activity 1.86972157198727 bayes_pls_golite062009
signal transducer activity 1.86972157198727 bayes_pls_golite062009
receptor activity 1.84800188265901 bayes_pls_golite062009
hormone receptor binding 1.8288193687002 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
transporter activity 1.29143782009237 bayes_pls_golite062009
steroid hormone receptor activity 1.28090460550476 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
structural constituent of ribosome 1.26313925559554 bayes_pls_golite062009
structural molecule activity 1.1947100233139 bayes_pls_golite062009
transmembrane transporter activity 1.07067346221546 bayes_pls_golite062009
substrate-specific transporter activity 0.801223278704275 bayes_pls_golite062009
transcription coactivator activity 0.61572149323953 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.546742121255473 bayes_pls_golite062009
cytoskeletal protein binding 0.405267736307896 bayes_pls_golite062009
ion transmembrane transporter activity 0.245837862213095 bayes_pls_golite062009
kinase binding 0.214936278413076 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [280-595] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGSAGDMRAA NLWPSPLMIK RSKKNSLALS LTADQMVSAL LDAEPPILYS EYDPTRPFSE  60
   61 ASMMGLLTNL ADRELVHMIN WAKRVPGFVD LTLHDQVHLL ECAWLEILMI GLVWRSMEHP 120
  121 GKLLFAPNLL LDRNQGKCVE GMVEIFDMLL ATSSRFRMMN LQGEEFVCLK SIILLNSGVY 180
  181 TFLSSTLKSL EEKDHIHRVL DKITDTLIHL MAKAGLTLQQ QHQRLAQLLL ILSHIRHMSN 240
  241 KGMEHLYSMK CKNVVPLYDL LLEMLDAHRL HAPTSRGGAS VEETDQSHLA TAGSTSSHSL 300
  301 QKYYITGEAE GFPATV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.39794
Match: 1a52A
Description: Estrogen receptor alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
estrogen receptor activity 5.90842909209137 bayes_pls_golite062009
transcription regulator activity 5.53061626347066 bayes_pls_golite062009
DNA binding 4.92165988569962 bayes_pls_golite062009
steroid hormone receptor activity 4.81441024181511 bayes_pls_golite062009
nucleic acid binding 4.78024150262074 bayes_pls_golite062009
transcription activator activity 4.53302455129434 bayes_pls_golite062009
receptor activity 4.24689654536725 bayes_pls_golite062009
estrogen response element binding 4.18628210805449 bayes_pls_golite062009
molecular transducer activity 4.18291345268856 bayes_pls_golite062009
signal transducer activity 4.18291345268856 bayes_pls_golite062009
sequence-specific DNA binding 4.11614358606713 bayes_pls_golite062009
transcription factor activity 4.0914094580319 bayes_pls_golite062009
nuclear hormone receptor binding 3.91470119037087 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 3.89763470197726 bayes_pls_golite062009
binding 3.85318710398432 bayes_pls_golite062009
transcription repressor activity 3.83878598697109 bayes_pls_golite062009
hormone receptor binding 3.79647267365529 bayes_pls_golite062009
protein binding 3.21524787168952 bayes_pls_golite062009
transcription activator binding 2.98235973123409 bayes_pls_golite062009
transcription factor binding 2.68044489404568 bayes_pls_golite062009
ecdysteroid hormone receptor activity 2.54335605534182 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.38308182853979 bayes_pls_golite062009
transcription coactivator activity 2.27959329058894 bayes_pls_golite062009
hormone binding 1.94707248239445 bayes_pls_golite062009
transcription cofactor activity 1.73827483890179 bayes_pls_golite062009
retinoic acid receptor binding 1.59968001933699 bayes_pls_golite062009
receptor binding 1.48687720837648 bayes_pls_golite062009
retinoid X receptor binding 1.45560845709347 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.34794228300778 bayes_pls_golite062009
promoter binding 1.28787959668198 bayes_pls_golite062009
palmitoyl-CoA hydrolase activity 1.23181585568439 bayes_pls_golite062009
steroid hormone receptor binding 1.22491987625613 bayes_pls_golite062009
transcription corepressor activity 0.995333369475571 bayes_pls_golite062009
steroid binding 0.933060984463406 bayes_pls_golite062009
retinoic acid receptor activity 0.853869057774515 bayes_pls_golite062009
retinoid binding 0.80514462928251 bayes_pls_golite062009
protein dimerization activity 0.797229273848179 bayes_pls_golite062009
isoprenoid binding 0.690820069629659 bayes_pls_golite062009
retinoic acid binding 0.676688935879073 bayes_pls_golite062009
protein N-terminus binding 0.57701453824007 bayes_pls_golite062009
thyroid hormone receptor activity 0.49784404390361 bayes_pls_golite062009
structure-specific DNA binding 0.47826452126899 bayes_pls_golite062009
lipid binding 0.475303782949439 bayes_pls_golite062009
protein heterodimerization activity 0.45265806678057 bayes_pls_golite062009
double-stranded DNA binding 0.42652610679613 bayes_pls_golite062009
androgen receptor activity 0.399730816072004 bayes_pls_golite062009
transmembrane receptor activity 0.289356295735737 bayes_pls_golite062009
ligand-regulated transcription factor activity 0.202197503742221 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.15737167800277 bayes_pls_golite062009
catalytic activity 0.106902059021677 bayes_pls_golite062009
androgen binding 0.0219623894804069 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle