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Protein Overview: ESR1

General Information:
Name(s) found: ESR1 [HGNC (HUGO)]
Description(s) found:
Found 54 descriptions.
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  • estrogen receptor 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 595 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY  60
   61 EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF 120
  121 LQPHGQQVPY YLENEPSGYT VREAGPPAFY RPNSDNRRQG GRERLASTND KGSMAMESAK 180
  181 ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC 240
  241 RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR 300
  301 SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA DRELVHMINW 360
  361 AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG 420
  421 MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSGVYT FLSSTLKSLE EKDHIHRVLD 480
  481 KITDTLIHLM AKAGLTLQQQ HQRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL 540
  541 LEMLDAHRLH APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] Pfam 38.677781 No description for PF02159.6 was found. No confident structure predictions are available.
    2 View Details [102..177] FFAS03 0.974 Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
    3 View Details [178..279] PSI-BLAST 22.0 Estrogen receptor DNA-binding domain
    4 View Details [280..595] PSI-BLAST 57.39794 Estrogen receptor alpha

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.55186574506963 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  2.19264900659739 bayes_pls_golite062009
  • androgen receptor binding
    		•  1.92232680714675 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.91348392022358 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.86972157198727 bayes_pls_golite062009
  • signal transducer activity
    		•  1.86972157198727 bayes_pls_golite062009
  • receptor activity
    		•  1.84800188265901 bayes_pls_golite062009
  • hormone receptor binding
    		•  1.8288193687002 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • transporter activity
    		•  1.29143782009237 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  1.28090460550476 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.26313925559554 bayes_pls_golite062009
  • structural molecule activity
    		•  1.1947100233139 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07067346221546 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801223278704275 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.61572149323953 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.546742121255473 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.405267736307896 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.245837862213095 bayes_pls_golite062009
  • kinase binding
    		•  0.214936278413076 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    4
    Term Confidence Notes
  • estrogen receptor activity
    		•  5.90842909209137 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  4.81441024181511 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • receptor activity
    		•  4.24689654536725 bayes_pls_golite062009
  • estrogen response element binding
    		•  4.18628210805449 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.18291345268856 bayes_pls_golite062009
  • signal transducer activity
    		•  4.18291345268856 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  3.91470119037087 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.83878598697109 bayes_pls_golite062009
  • hormone receptor binding
    		•  3.79647267365529 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription activator binding
    		•  2.98235973123409 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • ecdysteroid hormone receptor activity
    		•  2.54335605534182 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.27959329058894 bayes_pls_golite062009
  • hormone binding
    		•  1.94707248239445 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.59968001933699 bayes_pls_golite062009
  • receptor binding
    		•  1.48687720837648 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.45560845709347 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • promoter binding
    		•  1.28787959668198 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  1.23181585568439 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  1.22491987625613 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.995333369475571 bayes_pls_golite062009
  • steroid binding
    		•  0.933060984463406 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • retinoid binding
    		•  0.80514462928251 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.690820069629659 bayes_pls_golite062009
  • retinoic acid binding
    		•  0.676688935879073 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.47826452126899 bayes_pls_golite062009
  • lipid binding
    		•  0.475303782949439 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.42652610679613 bayes_pls_golite062009
  • androgen receptor activity
    		•  0.399730816072004 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.289356295735737 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009
  • androgen binding
    		•  0.0219623894804069 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle