YRC Public Data Repository - Protein Structure Prediction

Protein:	YOR262W
Organism:	Saccharomyces cerevisiae
Length:	347 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOR262W.

Description	E-value	Query Range	Subject Range
YOR262W - Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP... GPN2_YEAST - GPN-loop GTPase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GPN2 PE=1 SV=1 gi\|151945347 - gi\|151945347\|gb\|EDN63590.1\| conserved protein [Saccharomyces cerevisiae YJM789] gi\|207340964 - gi\|207340964\|gb\|EDZ69153.1\| YOR262Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190407566 - gi\|190407566\|gb\|EDV10833.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]	1.0E-94	[1..347]	[1..347]
SPAC144.07c - conserved eukaryotic protein GPN2_SCHPO - GPN-loop GTPase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gpn2 PE=3 SV=1	4.0E-76	[1..316]	[1..314]
GPN2_MACFA - GPN-loop GTPase 2 OS=Macaca fascicularis GN=GPN2 PE=2 SV=1 gi\|14043697, gi\|... - gi\|40254895\|ref\|NP_060536.2\| ATP binding domain 1 family, member B [Homo sapiens], gi\|37182846\|gb\|AA... gi\|114554966 - gi\|114554966\|ref\|XP_001146777.1\| PREDICTED: ATP binding domain 1 family, member B isoform 1 [Pan tro... gi\|108999773 - gi\|108999773\|ref\|XP_001110243.1\| PREDICTED: similar to ATP binding domain 1 family, member B [Macaca...	3.0E-68	[3..267]	[10..267]
GPN2_MOUSE, ATPB... - GPN-loop GTPase 2 OS=Mus musculus GN=Gpn2 PE=2 SV=1, ATP-binding domain 1 family member B - Mus musc...	1.0E-67	[3..304]	[10..306]
gi\|115454947, gi... - gi\|50918291\|ref\|XP_469542.1\| putative ATP(GTP)-binding protein [Oryza sativa (japonica cultivar-grou... gi\|125545504 - gi\|125545504\|gb\|EAY91643.1\| hypothetical protein OsI_012876 [Oryza sativa (indica cultivar-group)]	3.0E-66	[1..277]	[1..279]
gi\|24899793, gi\|... - gi\|79325073\|ref\|NP_001031621.1\| ATP-binding family protein [Arabidopsis thaliana], gi\|30682239\|ref\|N...	5.0E-65	[1..267]	[1..256]

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Predicted Domain #1

Region A:
Residues: [1-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFAQIVIGP PGSGKSTYCN GCSQFFNAIG RHSQVVNMDP ANDALPYPCA VDIRDFITLE  60
   61 EIMQEQQLGP NGGLMYAVES LDNSIDLFIL QIKSLVEEEK AYLVFDCPGQ VELFTHHSSL 120
  121 FNIFKKMEKE LDIRFCVVNL IDCFYMTSPS QYISILLLAL RSMLMMDLPH INVFSKIDML 180
  181 KSYGELPFRL DYYTEVQDLD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.522879
Match:	1fts__
Description:	Signal recognition particle receptor, FtsY; GTPase domain of the signal recognition particle receptor FtsY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.82708337557815	bayes_pls_golite062009
ion transmembrane transporter activity	2.73258998901465	bayes_pls_golite062009
transporter activity	2.58140740499725	bayes_pls_golite062009
cation transmembrane transporter activity	2.55141814687566	bayes_pls_golite062009
binding	2.44689197844883	bayes_pls_golite062009
transmembrane transporter activity	2.39695871109024	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
ATPase activity, coupled	2.18396165590908	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.93945622138684	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	1.89410061122763	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.63387464349089	bayes_pls_golite062009
nucleic acid binding	1.60768715809391	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
substrate-specific transporter activity	1.29730375126024	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.28706187447607	bayes_pls_golite062009
microtubule motor activity	1.170087579765	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.14579511548336	bayes_pls_golite062009
DNA binding	1.11699929651302	bayes_pls_golite062009
RNA helicase activity	1.02424782546779	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription regulator activity	0.989226939888218	bayes_pls_golite062009
RNA-dependent ATPase activity	0.95986988363392	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.94128341275411	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	0.699203719711999	bayes_pls_golite062009
motor activity	0.677658554107	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	0.600852003734846	bayes_pls_golite062009
active transmembrane transporter activity	0.434775387083003	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
primary active transmembrane transporter activity	0.294474570607914	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.282352478532746	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.220608508617331	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.219533217661421	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.219157471322311	bayes_pls_golite062009
cation channel activity	0.192467810264152	bayes_pls_golite062009
iron ion transmembrane transporter activity	0.160869143323446	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
protein binding	0.071010918255742	bayes_pls_golite062009
transcription factor activity	0.0434163635422169	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [201-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YLEPYIEKEG SSVLGKKYSK LTETIKELVS DFNLVSFEVL SVDDKESMIN LQGVIDKANG  60
   61 YIFGASEVGG DTVWAEASRE GALIANYDIQ DRWIDNKEKY DKEEEEKRTA LLKEQELQNK 120
  121 AVDVNEEDEW ENALKEWEEK QGMDFVR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.919	0.000	cytoplasm	c.84.1	Phosphoglucomutase, first 3 domains

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: