YRC Public Data Repository - Protein Structure Prediction

Protein:	CEX1
Organism:	Saccharomyces cerevisiae
Length:	761 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CEX1.

Description	E-value	Query Range	Subject Range
gi\|151945734 - gi\|151945734\|gb\|EDN63975.1\| cytoplasmic export protein [Saccharomyces cerevisiae YJM789] CEX1 - Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nu... CEX1_YEAST - Cytoplasmic export protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CEX1 PE=1 S...	0.0	[1..761]	[1..761]
SCYL1 - SCY1-like 1 (S. cerevisiae)	0.0	[6..753]	[3..760]
CE14688 - WBGene00012337 serine\/threonine kinase status:Partially_confirmed TR:Q23215 protein_id:CAB01444.1	0.0	[4..756]	[6..755]
NTKL_MOUSE - N-terminal kinase-like protein OS=Mus musculus GN=Scyl1 PE=1 SV=1	0.0	[6..711]	[3..744]
gi\|2462837, gi\|2... - pir\|\|F86362 F19G10.17 protein - Arabidopsis thaliana, gi\|2462837\|gb\|AAB72172.1\| hypothetical protei...	0.0	[108..747]	[1..635]
yata-PA, FBpp0305956 - The gene yata is referred to in FlyBase by the symbol Dmel\yata (CG1973, FBgn0260990). It is a prote...	0.0	[5..689]	[3..677]

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Predicted Domain #1

Region A:
Residues: [1-94]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFSSIFKSI SNFQFPYTIE ETAITETALW QCFDGTRKAD SLPVTVFKAK RSPENESLIL  60
   61 NAVHKSKILK IPGLCTVLET FDSDPQSTFI VTER

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [289-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENFIIPELCE IIKLLMTQSI SSAASPIGMN FNASHK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.0
Match:	1bmkA_
Description:	MAP kinase p38
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.29841996497296	bayes_pls_golite062009
protein kinase activity	1.70731294943064	bayes_pls_golite062009
protein binding	1.62406684925162	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.53010383910925	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.52597476013849	bayes_pls_golite062009
kinase activity	1.46967868776426	bayes_pls_golite062009
transmembrane receptor activity	1.20817899395165	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.13653556985891	bayes_pls_golite062009
receptor activity	1.13529255370019	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
protein serine/threonine kinase activity	0.940749450143365	bayes_pls_golite062009
transferase activity	0.876865688160088	bayes_pls_golite062009
signal transducer activity	0.814663047912932	bayes_pls_golite062009
molecular transducer activity	0.814663047912932	bayes_pls_golite062009
ATP binding	0.80100967388643	bayes_pls_golite062009
adenyl ribonucleotide binding	0.766575848955892	bayes_pls_golite062009
adenyl nucleotide binding	0.755570176026019	bayes_pls_golite062009
purine ribonucleotide binding	0.718880569902791	bayes_pls_golite062009
ribonucleotide binding	0.718820382381459	bayes_pls_golite062009
purine nucleotide binding	0.715416129764882	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.71378093587622	bayes_pls_golite062009
nucleotide binding	0.708369770220977	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
catalytic activity	0.673946834085468	bayes_pls_golite062009
nucleocytoplasmic transporter activity	0.543805639050221	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein tyrosine kinase activity	0.41304985993342	bayes_pls_golite062009
RNA binding	0.180581540285588	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [95-288]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVPFPWDNLG SLSQNKFGVE LGISQLLATL GFLKNFVLGT LSKDSVFINI KGEWVLFGLE  60
   61 LCSSKEGLSA FEFASRARSY YNIIGSQLPC EDPNTIDSMG LGLLIKSLMA PSCLPKDWIV 120
  121 NVNMISDGKI TIENFRKRLE NTETWRSNPL INFYQELREL HIKDPQGKLV VMSNLENLYL 180
  181 ESREIFRNLT PGMI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.0
Match:	1bmkA_
Description:	MAP kinase p38
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [325-653]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVPFLAIVLD LTSETNTFPV GFNDLITQSF KLPDRQVRFL LLIYLPKLIG PLSKSEISSR  60
   61 IYPHFIQGLT DSDATLRLQT LKTIPCIVSC LTERQLNNEL LRFLAKTQVD SDVEIRTWTV 120
  121 IIISKISTIL STSVGNRSNI LATAFTKSLK DPQVKPRLAA LYGLEKSIEL FDVNTIANKI 180
  181 LTVIAPGLLD KSPIVRGRAK ILFEEYLEKL EKEAQLIQTN DSTADSEDVK DIDFENYGCD 240
  241 EEDMNKEDNL LAAQFLNNLR LNSPSATTPS NITESEIDSA QDGSGWDDLS DTDGFITNGT 300
  301 TESFDETTNP VTTASTPKLF GKPIKINKS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.221849
Match:	1b3uA_
Description:	Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [654-761]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNDELNDDGW IQDESGPSKV PQKHTRPQNS TLAKSIAPSS RLSIKKKKTT ILAPRNIASN  60
   61 STVTTKSSLS NKTARSKPIS SIRGSVTKKG NVDGWDDDGD SDSWDTNW

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: