YRC Public Data Repository - Protein Structure Prediction

Protein:	ORC1
Organism:	Saccharomyces cerevisiae
Length:	914 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ORC1.

Description	E-value	Query Range	Subject Range
ORC1_YEAST - Origin recognition complex subunit 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ORC... ORC1 - Largest subunit of the origin recognition complex, which directs DNA replication by binding to repli...	0.0	[1..914]	[1..914]
ORC1_KLULA - Origin recognition complex subunit 1 OS=Kluyveromyces lactis GN=ORC1 PE=3 SV=2 ORC1_KLULA - Origin recognition complex subunit 1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 7079...	0.0	[1..913]	[1..885]
ORC1_CRIGR - Origin recognition complex subunit 1 OS=Cricetulus griseus GN=ORC1 PE=2 SV=1	9.0E-97	[84..908]	[151..850]
gi\|15079392 - gi\|15079392\|gb\|AAH11539.1\| Origin recognition complex, subunit 1-like (yeast) [Homo sapiens]	2.0E-96	[115..908]	[137..861]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-96	[115..908]	[137..861]
ORC1_MOUSE - Origin recognition complex subunit 1 OS=Mus musculus GN=Orc1l PE=2 SV=1	2.0E-94	[98..908]	[139..840]
ORC1_CANAX - Origin recognition complex subunit 1 OS=Candida albicans GN=ORC1 PE=2 SV=1	2.0E-89	[9..911]	[6..801]

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Predicted Domain #1

Region A:
Residues: [1-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKTLKDLQG WEIITTDEQG NIIDGGQKRL RRRGAKTEHY LKRSSDGIKL GRGDSVVMHN  60
   61 EAAGTYSVYM IQELRLNTLN NVVELWALTY LRWFEVNPLA HYRQFNPDAN ILNRPLNYYN 120
  121 KLFSETANKN ELYLTAELAE LQLFNFIRVA NVMDGSKWEV LKGNVDPERD FTVRYICEPT 180
  181 GEKFVDINIE DVKAYIKK

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	25.045757
Match:	PF01426
Description:	BAH domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
structural constituent of chromatin	5.63555259413678	bayes_pls_golite062009
DNA replication origin binding	4.6882205228007	bayes_pls_golite062009
nucleosomal histone binding	4.23077815319444	bayes_pls_golite062009
nucleosome binding	3.68770692323111	bayes_pls_golite062009
DNA binding	3.49504261357874	bayes_pls_golite062009
nucleic acid binding	3.45109302518995	bayes_pls_golite062009
chromatin binding	2.76371060113086	bayes_pls_golite062009
binding	2.47268310088535	bayes_pls_golite062009
structure-specific DNA binding	2.06404194869726	bayes_pls_golite062009
single-stranded DNA binding	1.99705816692751	bayes_pls_golite062009
double-stranded DNA binding	1.92992435554938	bayes_pls_golite062009
sequence-specific DNA binding	1.53908742265394	bayes_pls_golite062009
structural molecule activity	1.23840733283098	bayes_pls_golite062009
histone binding	0.8857281851882	bayes_pls_golite062009
protein binding	0.634982583867058	bayes_pls_golite062009
catalytic activity	0.424959044318554	bayes_pls_golite062009
protein dimerization activity	0.0647375627009996	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [199-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEPREAQEYL KDLTLPSKKK EIKRGPQKKD KATQTAQISD AETRATDITD NEDGNEDESS  60
   61 DYESPSDIDV SEDMDSGEIS ADELEEEEDE EEDEDEEEKE ARHTNSPRKR GRKIKLGKDD 120
  121 IDASVQP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.300	0.433	pre-replicative complex assembly	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.208	0.086	pre-replicative complex assembly	a.118.8	TPR-like
View	Download	0.357	0.010	pre-replicative complex assembly	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains

Predicted functions:

Term	Confidence	Notes
DNA clamp loader activity	3.22518920754305	bayes_pls_golite062009
protein-DNA loading ATPase activity	3.19273435123154	bayes_pls_golite062009
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.66107861968804	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
DNA helicase activity	2.2817164193758	bayes_pls_golite062009
pyrophosphatase activity	2.13284212711072	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.88455339138556	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
RNA helicase activity	1.63960194106079	bayes_pls_golite062009
DNA replication origin binding	1.62491387774159	bayes_pls_golite062009
ATP-dependent RNA helicase activity	1.61735400124552	bayes_pls_golite062009
RNA-dependent ATPase activity	1.60404584546501	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.971476020912368	bayes_pls_golite062009
DNA polymerase activity	0.928091843881235	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
transcription repressor activity	0.862685397469217	bayes_pls_golite062009
structure-specific DNA binding	0.782430219754236	bayes_pls_golite062009
motor activity	0.61636596887462	bayes_pls_golite062009
double-stranded DNA binding	0.6071273686445	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.147579541298736	bayes_pls_golite062009
nucleotide binding	0.114848452385726	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.113504049290503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.111293884322157	bayes_pls_golite062009
purine nucleotide binding	0.10713474095071	bayes_pls_golite062009
purine ribonucleotide binding	0.0916519414118148	bayes_pls_golite062009
ribonucleotide binding	0.0915913646217636	bayes_pls_golite062009
structural constituent of ribosome	0.089234257580272	bayes_pls_golite062009
3'-5' DNA helicase activity	0.0769112340058804	bayes_pls_golite062009
cytoskeletal protein binding	0.0272673919333979	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [326-409]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPKKRGRKPK DPSKPRQMLL ISSCRANNTP VIRKFTKKNV ARAKKKYTPF SKRFKSIAAI  60
   61 PDLTSLPEFY GNSSELMASR FENK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.444	d.43.1	Elongation factor Ts (EF-Ts), dimerisation domain
View	Download	0.391	a.59.1	PAH2 domain
View	Download	0.467	a.181.1	Antibiotic binding domain of TipA-like multidrug resistance regulators
View	Download	0.453	a.69.3	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View	Download	0.368	d.57.1	DNA damage-inducible protein DinI
View	Download	0.362	a.58.1	Chemotaxis receptor methyltransferase CheR, N-terminal domain
View	Download	0.338	a.77.1	DEATH domain
View	Download	0.321	a.135.1	Tetraspanin
View	Download	0.311	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.289	a.4.1	Homeodomain-like
View	Download	0.279	a.112.1	Description not found.
View	Download	0.262	d.109.1	Actin depolymerizing proteins
View	Download	0.258	a.5.3	N-terminal domain of phosphatidylinositol transfer protein sec14p
View	Download	0.246	a.74.1	Cyclin-like
View	Download	0.237	a.60.13	Putative methyltransferase TM0872, insert domain
View	Download	0.225	a.24.17	Group V grass pollen allergen
View	Download	0.223	a.61.1	Retroviral matrix proteins
View	Download	0.213	a.144.2	Ribosomal protein L20

Predicted Domain #4

Region A:
Residues: [410-626]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKTTQKHQIV ETIFSKVKKQ LNSSYVKEEI LKSANFQDYL PARENEFASI YLSAYSAIES  60
   61 DSATTIYVAG TPGVGKTLTV REVVKELLSS SAQREIPDFL YVEINGLKMV KPTDCYETLW 120
  121 NKVSGERLTW AASMESLEFY FKRVPKNKKK TIVVLLDELD AMVTKSQDIM YNFFNWTTYE 180
  181 NAKLIVIAVA NTMDLPERQL GNKITSRIGF TRIMFTG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.39794
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [627-758]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTHEELKNII DLRLKGLNDS FFYVDTKTGN AILIDAAGND TTVKQTLPED VRKVRLRMSA  60
   61 DAIEIASRKV ASVSGDARRA LKVCKRAAEI AEKHYMAKHG YGYDGKTVIE DENEEQIYDD 120
  121 EDKDLIESNK AK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.39794
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [759-914]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDNDDDDDND GVQTVHITHV MKALNETLNS HVITFMTRLS FTAKLFIYAL LNLMKKNGSQ  60
   61 EQELGDIVDE IKLLIEVNGS NKFVMEIAKT LFQQGSDNIS EQLRIISWDF VLNQLLDAGI 120
  121 LFKQTMKNDR ICCVKLNISV EEAKRAMNED ETLRNL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: