YRC Public Data Repository - Protein Structure Prediction

Protein:	HBS1
Organism:	Saccharomyces cerevisiae
Length:	611 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HBS1.

Description	E-value	Query Range	Subject Range
EF1A1_CANAL - Elongation factor 1-alpha 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TEF1 PE=3 SV=1 EF1A_CANAL - Elongation factor 1-alpha OS=Candida albicans GN=TEF1 PE=1 SV=1 gi\|238878741, gi... - gi\|238883715\|gb\|EEQ47353.1\| elongation factor 1-alpha [Candida albicans WO-1], gi\|238878741\|gb\|EEQ42...	0.0	[163..611]	[3..441]
EF1A_ABSGL - Elongation factor 1-alpha OS=Absidia glauca GN=TEF-1 PE=3 SV=1	0.0	[163..611]	[3..441]
gi\|13278382 - gi\|13278382\|gb\|AAH04005.1\| Eukaryotic translation elongation factor 1 alpha 1 [Mus musculus]	0.0	[163..611]	[3..443]
gi\|169409549 - gi\|169409549\|gb\|ACA57895.1\| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Calliceb... EF1A1_PANTR - Elongation factor 1-alpha 1 OS=Pan troglodytes GN=EEF1A1 PE=2 SV=1 gi\|163781003 - gi\|163781003\|gb\|ABY40784.1\| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Papio an... gi\|67970565 - gi\|67970565\|dbj\|BAE01625.1\| unnamed protein product [Macaca fascicularis] EF1A1_PONAB - Elongation factor 1-alpha 1 OS=Pongo abelii GN=EEF1A1 PE=2 SV=2 EEF1A1 - eukaryotic translation elongation factor 1 alpha 1 gi\|60819043, gi\|... - gi\|61363070\|gb\|AAX42329.1\| eukaryotic translation elongation factor 1 alpha 1 [synthetic construct],... gi\|73973292 - gi\|73973292\|ref\|XP_532203.2\| PREDICTED: similar to eukaryotic translation elongation factor 1 alpha ... gi\|229368700 - gi\|229368700\|gb\|ACQ62985.1\| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Dasypus ... tr\|F6UME7\|F6UME7... - Elongation factor 1-alpha OS=Equus caballus OX=9796 GN=EEF1A1 PE=3 SV=1 gi\|56342332\|dbj\|... - eukaryotic translation elongation factor 1 alpha 1 [Pan troglodytes] EF1A1_BOVIN - Elongation factor 1-alpha 1 OS=Bos taurus GN=EEF1A1 PE=1 SV=1 EF1A1_PONPY - Elongation factor 1-alpha 1 - Pongo pygmaeus (Orangutan) EF1A1_RABIT - Elongation factor 1-alpha 1 OS=Oryctolagus cuniculus GN=EEF1A1 PE=1 SV=1 gi\|109071708, gi... - gi\|109071710\|ref\|XP_001112777.1\| PREDICTED: similar to eukaryotic translation elongation factor 1 al... EF1A1_FELCA - Elongation factor 1-alpha 1 OS=Felis catus GN=EEF1A1 PE=2 SV=1 gi\|223019597, gi... - gi\|223019599\|emb\|CAX36487.1\| eukaryotic translation elongation factor 1 alpha 1 [Sus scrofa], gi\|223... ENSCJAT00000019570 - null	0.0	[163..611]	[3..443]
gi\|15805031, gi\|... - gi\|15805031\|ref\|NP_284925.1\| eukaryotic translation elongation factor 1 alpha 2 [Rattus norvegicus],...	0.0	[163..611]	[3..443]
EF1A3_RHIRA, EF1... - Elongation factor 1-alpha OS=Rhizomucor racemosus GN=TEF-3 PE=3 SV=1, (P14865) Elongation factor 1-a... EF1A3_MUCCL - Elongation factor 1-alpha OS=Mucor circinelloides f. lusitanicus GN=TEF-3 PE=3 SV=1	0.0	[163..611]	[3..440]
EF1A_CHICK - Elongation factor 1-alpha 1 OS=Gallus gallus GN=EEF1A PE=2 SV=1	0.0	[163..611]	[3..443]
EF1A0_XENLA - Elongation factor 1-alpha, somatic form OS=Xenopus laevis GN=eef1as PE=2 SV=1	0.0	[163..611]	[3..443]
EF1A_BLAAD - Elongation factor 1-alpha OS=Blastobotrys adeninivorans GN=TEF PE=3 SV=1 EF1A_ARXAD - Elongation factor 1-alpha OS=Arxula adeninivorans GN=TEF PE=3 SV=1	0.0	[163..611]	[3..441]

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Predicted Domain #1

Region A:
Residues: [1-152]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYSDYSDGA DDMPDFHDEG EFDDYLNDDE YDLMNEVFPT LKAQLQDYQG WDNLSLKLAL  60
   61 FDNNFDLEST LAELKKTLKK KKTPKKPIAA ANGSANVTQK LANISISQQR PNDRLPDWLD 120
  121 EEESEGERNG EEANDEKTVQ RYYKTTVPTK PK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.245	0.295	translation	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.245	0.028	GTPase activity	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.214	0.027	cytoplasm	c.30.1	PreATP-grasp domain
View	Download	0.406	0.025	cytoplasm	c.16.1	Lumazine synthase
View	Download	0.214	0.007	GTPase activity	c.30.1	PreATP-grasp domain
View	Download	0.236	0.007	cytoplasm	c.23.4	Succinyl-CoA synthetase domains
View	Download	0.406	0.007	GTPase activity	c.16.1	Lumazine synthase
View	Download	0.236	0.002	GTPase activity	c.23.4	Succinyl-CoA synthetase domains

Predicted Domain #2

Region A:
Residues: [153-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPHDISAFVK SALPHLSFVV LGHVDAGKST LMGRLLYDLN IVNQSQLRKL QRESETMGKS  60
   61 SFKFAWIMDQ TNEERERGVT VSICTSHFST HRANFTIVDA PGHRDFVPNA IMGISQADMA 120
  121 ILCVDCSTNA FESGFDLDGQ TKEHMLLASS LGIHNLIIAM NKMDNVDWSQ QRFEEIKSKL 180
  181 LPYLVDIGFF EDNINWVPIS GFSGEGVYKI EYTDEVRQWY NGPNLMSTLE NAAFKISKEN 240
  241 E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1580.0
Match:	1jnyA_
Description:	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation elongation factor activity	8.90683166637832	bayes_pls_golite062009
translation factor activity, nucleic acid binding	4.8378725567094	bayes_pls_golite062009
translation regulator activity	4.79814772079421	bayes_pls_golite062009
actin binding	2.84620358490972	bayes_pls_golite062009
cytoskeletal protein binding	2.66896300219871	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
hydrolase activity	2.55157966585974	bayes_pls_golite062009
actin filament binding	2.1683792904715	bayes_pls_golite062009
motor activity	1.64238426331767	bayes_pls_golite062009
nucleic acid binding	1.49633029954726	bayes_pls_golite062009
purine ribonucleotide binding	1.2935968641033	bayes_pls_golite062009
ribonucleotide binding	1.2935353851804	bayes_pls_golite062009
purine nucleotide binding	1.29138695385133	bayes_pls_golite062009
nucleotide binding	1.28669586915546	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription regulator activity	0.989226939888218	bayes_pls_golite062009
ATP binding	0.98146619596929	bayes_pls_golite062009
DNA binding	0.967303417236485	bayes_pls_golite062009
adenyl ribonucleotide binding	0.949788783884952	bayes_pls_golite062009
adenyl nucleotide binding	0.931486373329219	bayes_pls_golite062009
protein methyltransferase activity	0.876296121718575	bayes_pls_golite062009
microtubule motor activity	0.87576779858246	bayes_pls_golite062009
structural constituent of ribosome	0.860102064846772	bayes_pls_golite062009
microfilament motor activity	0.842051467704019	bayes_pls_golite062009
RNA binding	0.715902454627085	bayes_pls_golite062009
kinase activity	0.691112783105676	bayes_pls_golite062009
histone methyltransferase activity	0.63002958837536	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.499834566483656	bayes_pls_golite062009
	0.3172470686972	bayes_pls_golite062009
ribonuclease activity	0.222424272323909	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.147579541298736	bayes_pls_golite062009
pyrophosphatase activity	0.133017653323467	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.113504049290503	bayes_pls_golite062009
structural molecule activity	0.11239762372728	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.111293884322157	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
transcription factor activity	0.0434163635422169	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0430764033739892	bayes_pls_golite062009
protein kinase activity	0.0364322017534667	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [394-500]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GINKDDPFLF SVLEIIPSKK TSNDLALVSG KLESGSIQPG ESLTIYPSEQ SCIVDKIQVG  60
   61 SQQGQSTNHE ETDVAIKGDF VTLKLRKAYP EDIQNGDLAA SVDYSSI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1580.0
Match:	1jnyA_
Description:	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [501-611]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSAQCFVLEL TTFDMNRPLL PGTPFILFIG VKEQPARIKR LISFIDKGNT ASKKKIRHLG  60
   61 SKQRAFVEIE LIEVKRWIPL LTAHENDRLG RVVLRKDGRT IAAGKISEIT Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1580.0
Match:	1jnyA_
Description:	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: