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View Structure Prediction Details

Protein: NMD5
Organism: Saccharomyces cerevisiae
Length: 1048 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NMD5.

Description E-value Query
Range
Subject
Range
NMD5 - Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog
0.0 [1..1048] [1..1048]
gi|31581595, gi|... - ref|NP_852658.1| importin 7 [Mus musculus], gi|11342591|emb|CAC17143.1| RanBP7/importin 7 [Mus musc...
0.0 [1..1046] [1..997]
IPO7 - importin 7
gi|73988461 - gi|73988461|ref|XP_542501.2| PREDICTED: similar to Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7...
0.0 [1..1046] [1..996]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..1046] [1..996]
msk-PA - The gene moleskin is referred to in FlyBase by the symbol Dmel\msk (CG7935, FBgn0026252). It is a pr...
0.0 [1..1045] [1..1012]
IMA3_SCHPO - Probable importin c550.11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC550.11 PE=3 ...
SPCC550.11 - karyopherin
0.0 [6..1043] [3..1012]

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Predicted Domain #1
Region A:
Residues: [1-726]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDITELLQCF ACTLDHNAAV RTNAETHLKN ASKVPGFLGA CLDIIAADEV PENIKLSASL  60
   61 YFKNKITYGW SAGARQGSNE LLDSHVDPDE KPVVKDMLIK TMVSVSKTSP RCIRVLKSAL 120
  121 TVIISEDYPS KKWGNLLPNS LELLANEDIT VTYVGLLCLA EIFRTYRWKN NDERQDLEEL 180
  181 ILNYFPALLN YGANVLFQDG KYMNNEQIGE LVKLIIKIYK FVSYHDLPFT LQRSESFTPW 240
  241 ACFFVSIIQQ PLPQEVLSIS DIEVRSKNPW VKCKKWALAN LYRLFQRYAS TSLTRKFQYD 300
  301 EFKQMYCEEF LTQFLQVVFD QIEKWGTGQL WLSDECLYYI LNFVEQCVVQ KTTWKLVGPH 360
  361 YNVILQHVIF PLLKPTAETL EAFDNDPQEY INRNMDFWDV GYSPDLAALA LLTTCVTKRG 420
  421 KTTLQPTLEF MVSTLQSAVG DYNNIMLDNA LQIESCLRIF SSIIDRLITK DSPFASEMEK 480
  481 FILTYVLPFF KSQYGFLQSR VCDICSKLGS MDFKDPVITS TIYEGVMNCL NNSSNSLPVE 540
  541 LTAALALQTF ISDDQFNMKL SEHVVPTMQK LLSLSNDFES DVISGVMQDF VEQFAEQLQP 600
  601 FGVELMNTLV QQFLKLAIDL HETSNLDPDS FTNVDSIPDE SDKQMAALGI LSTTISILLS 660
  661 FENSPEILKN LEQSFYPAAE FILKNDIEDF YRECCEFVEN STFLLRDITP ISWKILELIG 720
  721 ECNRKP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
nuclear export signal receptor activity 2.13470398426489 bayes_pls_golite062009
cytoskeletal protein binding 1.97003189625955 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
molecular transducer activity 1.51103985174196 bayes_pls_golite062009
signal transducer activity 1.51103985174196 bayes_pls_golite062009
actin binding 1.4328432044371 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
RNA binding 1.20550543134698 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
nucleic acid binding 1.00841167631924 bayes_pls_golite062009
peptide binding 0.61212282188613 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
structural molecule activity 0.449804281824548 bayes_pls_golite062009
transcription regulator activity 0.385452858197632 bayes_pls_golite062009
mRNA binding 0.37278269424461 bayes_pls_golite062009
DNA binding 0.309260217284589 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [727-866]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSMVSYYLSD FMLALNNILI YGRNELKKNE FYTKIIFEIY QKAVTAEDNS LDDLRVVFDL  60
   61 SQELVLALDD SLPQQYRERL LADVVGSILT QKNELKTNVV FSVTAFNVVI SNMITEPLIT 120
  121 LQYLKQQGCL EIFFQTWITD 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.576 0.159 protein transmembrane transporter activity a.1.1 Globin-like
View Download 0.568 0.031 protein transmembrane transporter activity a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.796 0.031 protein transmembrane transporter activity a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.573 0.027 protein transmembrane transporter activity f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.617 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.499 N/A N/A a.74.1 Cyclin-like
View Download 0.428 N/A N/A e.37.1 Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
View Download 0.416 N/A N/A a.1.1 Globin-like
View Download 0.411 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.406 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.362 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.351 N/A N/A a.29.2 Bromodomain
View Download 0.332 N/A N/A a.24.11 Bacterial GAP domain
View Download 0.329 N/A N/A a.5.4 Elongation factor TFIIS domain 2
View Download 0.322 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.317 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.314 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.313 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.312 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.311 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.303 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.303 N/A N/A a.118.8 TPR-like
View Download 0.298 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.282 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.274 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.266 N/A N/A a.74.1 Cyclin-like
View Download 0.264 N/A N/A a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.263 N/A N/A a.39.1 EF-hand
View Download 0.261 N/A N/A d.8.1 Urease, gamma-subunit
View Download 0.260 N/A N/A a.5.4 Elongation factor TFIIS domain 2
View Download 0.260 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.253 N/A N/A a.74.1 Cyclin-like
View Download 0.248 N/A N/A a.118.8 TPR-like
View Download 0.248 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.245 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.244 N/A N/A a.83.1 Guanido kinase N-terminal domain
View Download 0.236 N/A N/A c.23.14 Nucleoside 2-deoxyribosyltransferase
View Download 0.232 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.230 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.229 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.227 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.225 N/A N/A a.74.1 Cyclin-like
View Download 0.224 N/A N/A d.92.1 Metalloproteases ("zincins"), catalytic domain
View Download 0.220 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.220 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.218 N/A N/A a.1.1 Globin-like
View Download 0.215 N/A N/A d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.215 N/A N/A a.118.8 TPR-like
View Download 0.214 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.211 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.208 N/A N/A a.26.1 4-helical cytokines
View Download 0.206 N/A N/A d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.204 N/A N/A a.5.4 Elongation factor TFIIS domain 2
View Download 0.200 N/A N/A a.7.6 Ribosomal protein S20

Predicted Domain #3
Region A:
Residues: [867-1048]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YIPNYKRCYD IKLSVLALLK IILKLESNDY SVLNLENLVP QLGSIVTQLA SRLPTALRQL  60
   61 ANQRKEFSSS GFEEDTKWDE NFLDVGDDDE NDDEGDLTEK YLELIKNRAD SLDFVDGYDA 120
  121 KETFDDLEED PLTGSILDTV DVYKVFKESI ANLQHVDSNR YQGILRHLTP ADQELFMGIM 180
  181 NA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.733 0.031 protein transmembrane transporter activity a.24.9 alpha-catenin/vinculin
View Download 0.413 0.021 protein transmembrane transporter activity a.47.2 t-snare proteins
View Download 0.271 0.016 protein transmembrane transporter activity f.13.1 Family A G protein-coupled receptor-like
View Download 0.362 0.006 protein transmembrane transporter activity f.15.1 Small-conductance potassium channel
View Download 0.339 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.226 N/A N/A a.24.1 Apolipoprotein
View Download 0.221 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.221 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.213 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.203 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.203 N/A N/A a.47.2 t-snare proteins
View Download 0.203 N/A N/A d.92.1 Metalloproteases ("zincins"), catalytic domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle