Protein Overview: msk-PA

General Information:
Name(s) found:	msk-PA / FBpp0076408 [FlyBase]
Description(s) found: Found 23 descriptions. SHOW ALL	The gene moleskin is referred to in FlyBase by the symbol Dmel\msk (CG7935, FBgn0026252). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:8109278..8114681. It has the cytological map location 66B6. Based on sequence similarity, it is predicted to have molecular function</span>: Ran GTPase binding; protein transmembrane transporter activity. There is experimental evidence for 15 unique biological process</span> terms, many of which group under: anatomical structure development; organ morphogenesis; sensory organ development; regulation of biological process; protein localization in nucleus; transmembrane receptor protein tyrosine kinase signaling pathway; nucleocytoplasmic transport; organ development; cell proliferation; compound eye cone cell differentiation; ommatidial rotation; nuclear import; regulation of apoptosis; enzyme linked receptor protein signaling pathway. 11 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L5; posterior crossvein; crossvein; anterior crossvein; wing vein L4; wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1049 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] perinuclear region of cytoplasm [IDA] cytoplasm [IDA][ISS] cell cortex [IDA] nuclear pore [ISS]
Biological Process:	cell proliferation [IMP] wing cell fate specification [IMP] ommatidial rotation [IMP] epidermal growth factor receptor signaling pathway [IGI] imaginal disc-derived wing morphogenesis [IMP] transmembrane receptor protein tyrosine kinase signaling pathway [IPI] imaginal disc-derived wing vein morphogenesis [IMP] imaginal disc-derived wing vein specification [IMP] R8 cell differentiation [IMP] compound eye cone cell differentiation [IMP] compound eye development [IGI][IMP] nuclear translocation of MAPK [IMP] negative regulation of neuron apoptosis [IMP] rhabdomere development [IMP] protein import into nucleus [IDA][ISS][TAS]
Molecular Function:	protein transmembrane transporter activity [ISS] protein transporter activity [IEA] binding [IEA] Ran GTPase binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAQKLTELL RATIDPNPEQ RKAAEDQLAQ IHKIIGFVPT ILQIVMQTTV EQPVRQAGAV  60
   61 YLKNLINSSW SDHEAKPGEP IPFSIHEQDR AMIRGAIVDA IVHAPELIRV QLSVCVNHII 120
  121 KSDFPGRWPQ VVDSISIYLQ NQDVNGWNGA LVTMYQLVKT YEYKRHEERT PLNEAMNLLL 180
  181 PMIYQLMVRL LAEQSEQSVL LQKQILKIYY ALTQYTLPLD LITKEIFSQW MEICRQVADR 240
  241 AVPDSSHLDD DERTEFPYWK TKKWALHIMV RMFERYGSPS NVVSEKYQKF AEWYLPTFSQ 300
  301 GVLEVLLKIL DQYRNRVYVS PRVLTDVLNY LKNAVSHAYT WKLIKPHMVA VIQDVIFPIM 360
  361 SFTDSDQELW ESDPYEYIRL KFDIFEDYAT PVPAAQSLLH SMCKKRKGIL PKAMATIMQI 420
  421 ITSPNADNKQ KDGALHMIGT LADVLLKKAS YRDQVESMLT TYVFPEFQNP AGHMRARACW 480
  481 VLHYFCDVQI KNPQVLAEIM RLTTNALLTD KELPVKVEAA IGLQMFISSQ DEAPQYVEAQ 540
  541 IKEITKELLT IIRETENEDL TNVMQKIVCT FTEQLLPVAT EICQHLATTF SQVLESEEGS 600
  601 DEKAITAMSL LNTIETLLSV MEEHPDVLLN LHPIVINVVG HIFQHNITDF YEETFSLVYD 660
  661 LTAKAISPEM WQMLELIYQV FKKDGIDYFI DIMPALHNYV TVDTPAFLSN PNRLLAILDM 720
  721 CKTMLTSSPG EDPECHAAKL MEVIILQCKG QIDSVIHMFV ELALSRLTRE VQSSELRTMC 780
  781 LQVVIAALYY NPQLLLSILD KMSQQNNDSI SAHFIKQWLH DTDCFLGIHD RKLCVLGLCT 840
  841 LISLGEAKPQ VLSEVAGKIV PALILLFDGL KRAYESRAQE EEEDEEEEDG DDCEEALSSD 900
  901 EDDMDEMAPD YLDKLAEFAK TKGNESGFEV KAEIKDDDAD SDGDAEESVG DLNETGLESF 960
  961 TTPIDDEENE SAIDEYWTFK EVITALSAQD QAWYALLTSN LTPEQAKALQ EVVVTADQRK1020
 1021 AAKESKLIEK QGGFAFPQTA VPTSFKFGS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Protein Overview: msk-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: