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View Structure Prediction Details

Protein: SEC27
Organism: Saccharomyces cerevisiae
Length: 889 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC27.

Description E-value Query
Range		 Subject
Range
COPB2_MOUSE - Coatomer subunit beta' OS=Mus musculus GN=Copb2 PE=1 SV=2
 0.0 [1..888] [3..851]
COPB2 - coatomer protein complex, subunit beta 2 (beta prime)
 0.0 [1..888] [3..851]
COPB2_BOVIN - Coatomer subunit beta' - Bos taurus (Bovine)
 0.0 [1..888] [3..851]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..888] [3..851]
COPB2_RAT - Coatomer subunit beta' OS=Rattus norvegicus GN=Copb2 PE=1 SV=3
 0.0 [1..888] [3..851]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
 0.0 [14..658] [865..1494]
COB22_ARATH - Coatomer subunit beta'-2 OS=Arabidopsis thaliana GN=At1g52360 PE=2 SV=1
 0.0 [1..889] [3..850]
COPB2_YEAST - Coatomer subunit beta' OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC27 PE=1 SV=1
gi|190407086 - gi|190407086|gb|EDV10353.1| yeast coatomer beta'-subunit [Saccharomyces cerevisiae RM11-1a]
SEC27 - Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport...
 0.0 [1..853] [1..853]

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Predicted Domain #1
Region A:
Residues: [1-311] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLDIKKTFS NRSDRVKGID FHPTEPWVLT TLYSGRVELW NYETQVEVRS IQVTETPVRA  60
   61 GKFIARKNWI IVGSDDFRIR VFNYNTGEKV VDFEAHPDYI RSIAVHPTKP YVLSGSDDLT 120
  121 VKLWNWENNW ALEQTFEGHE HFVMCVAFNP KDPSTFASGC LDRTVKVWSL GQSTPNFTLT 180
  181 TGQERGVNYV DYYPLPDKPY MITASDDLTI KIWDYQTKSC VATLEGHMSN VSFAVFHPTL 240
  241 PIIISGSEDG TLKIWNSSTY KVEKTLNVGL ERSWCIATHP TGRKNYIASG FDNGFTVLSL 300
  301 GNDEPTLSLD P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 219.68867
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [312-377] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGKLVWSGGK NAAASDIFTA VIRGNEEVEQ DEPLSLQTKE LGSVDVFPQS LAHSPNGRFV  60
   61 TVVGDG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [378-629] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYVIYTALAW RNKAFGKCQD FVWGPDSNSY ALIDETGQIK YYKNFKEVTS WSVPMHSAID  60
   61 RLFSGALLGV KSDGFVYFFD WDNGTLVRRI DVNAKDVIWS DNGELVMIVN TNSNGDEASG 120
  121 YTLLFNKDAY LEAANNGNID DSEGVDEAFD VLYELSESIT SGKWVGDVFI FTTATNRLNY 180
  181 FVGGKTYNLA HYTKEMYLLG YLARDNKVYL ADREVHVYGY EISLEVLEFQ TLTLRGEIEE 240
  241 AIENVLPNVE GK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.0
Match: 1c5kA_
Description: TolB, C-terminal domain; TolB, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
histone methyltransferase activity (H3-K4 specific) 4.71992275913384 bayes_pls_golite062009
actin binding 3.31804728298431 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.25521258308263 bayes_pls_golite062009
cytoskeletal protein binding 3.1056443224755 bayes_pls_golite062009
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
dynein binding 2.54821997913979 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 1.95667720244696 bayes_pls_golite062009
nucleic acid binding 1.90457914882449 bayes_pls_golite062009
histone methyltransferase activity 1.85632145559025 bayes_pls_golite062009
dynactin binding 1.85146647785657 bayes_pls_golite062009
actin filament binding 1.5197243426595 bayes_pls_golite062009
structural molecule activity 1.47448876401574 bayes_pls_golite062009
DNA binding 1.38475369554616 bayes_pls_golite062009
protein methyltransferase activity 1.35170368882651 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.22384651674093 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
protein transporter activity 0.964340340346761 bayes_pls_golite062009
transcription factor activity 0.804334981068351 bayes_pls_golite062009
molecular transducer activity 0.762533049716683 bayes_pls_golite062009
signal transducer activity 0.762533049716683 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
transcription repressor activity 0.560226369775279 bayes_pls_golite062009
0.53274018413176 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.426429095658617 bayes_pls_golite062009
transcription factor binding 0.412844855996155 bayes_pls_golite062009
kinase activity 0.387572734234845 bayes_pls_golite062009
snoRNA binding 0.347797037104681 bayes_pls_golite062009
protein kinase activity 0.229242350006544 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.226335610368636 bayes_pls_golite062009
transcription cofactor activity 0.19391619547146 bayes_pls_golite062009
receptor activity 0.151162384440161 bayes_pls_golite062009
structural constituent of cytoskeleton 0.118975415284669 bayes_pls_golite062009
transcription corepressor activity 0.00954741955203087 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009
N-methyltransferase activity 0.00335766408304172 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [630-812] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSLTKIARFL EGQEYYEEAL NISPDQDQKF ELALKVGQLT LARDLLTDES AEMKWRALGD  60
   61 ASLQRFNFKL AVEAFTNAHD LESLFLLHSS FNNKEGLVTL AKDAERAGKF NLAFNAYWIA 120
  121 GDIQGAKDLL IKSQRFSEAA FLGSTYGLGD DAVNDIVTKW KENLILNGKN TVSERVCGAE 180
  181 GLP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.2
Match: 1b89A
Description: Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.64850159998065 bayes_pls_golite062009
transcription regulator activity 1.96534484578496 bayes_pls_golite062009
nucleic acid binding 1.64804251600372 bayes_pls_golite062009
DNA binding 1.63530462331869 bayes_pls_golite062009
protein binding 1.51322932625387 bayes_pls_golite062009
transcription factor activity 0.941893540415683 bayes_pls_golite062009
signal transducer activity 0.924191975589092 bayes_pls_golite062009
molecular transducer activity 0.924191975589092 bayes_pls_golite062009
signal sequence binding 0.791153798439582 bayes_pls_golite062009
N-acetyltransferase activity 0.597017459591015 bayes_pls_golite062009
transcription factor binding 0.370606597126089 bayes_pls_golite062009
N-acyltransferase activity 0.36489074781643 bayes_pls_golite062009
enzyme binding 0.335436488591595 bayes_pls_golite062009
receptor activity 0.228157571114804 bayes_pls_golite062009
peroxisome targeting sequence binding 0.209148717913838 bayes_pls_golite062009
transferase activity 0.157308242400253 bayes_pls_golite062009
transcription cofactor activity 0.0874081614883346 bayes_pls_golite062009
acetyltransferase activity 0.0217632433282022 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [813-889] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSSSGDAQP LIDLDSTPAP EQADENKEAE VEDSEFKESN SEAVEAEKKE EEAPQQQQSE  60
   61 QQPEQGEAVP EPVEEES

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.356 0.466 retrograde vesicle-mediated transport, Golgi to ER a.4.5 "Winged helix" DNA-binding domain
View Download 0.363 0.014 retrograde vesicle-mediated transport, Golgi to ER a.4.8 Ribosomal protein S18
View Download 0.409 0.011 retrograde vesicle-mediated transport, Golgi to ER a.11.1 Acyl-CoA binding protein
View Download 0.603 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.474 N/A N/A a.64.2 Bacteriocin AS-48
View Download 0.356 N/A N/A a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.327 N/A N/A a.28.2 Colicin E immunity proteins
View Download 0.325 N/A N/A a.23.5 Hemolysin expression modulating protein HHA
View Download 0.306 N/A N/A a.64.2 Bacteriocin AS-48
View Download 0.262 N/A N/A a.118.1 ARM repeat
View Download 0.246 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.216 N/A N/A a.4.1 Homeodomain-like
View Download 0.209 N/A N/A a.4.5 "Winged helix" DNA-binding domain

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle