YRC Public Data Repository - Protein Structure Prediction

Protein:	SXM1
Organism:	Saccharomyces cerevisiae
Length:	944 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SXM1.

Description	E-value	Query Range	Subject Range
IPO7 - importin 7 gi\|73988461 - gi\|73988461\|ref\|XP_542501.2\| PREDICTED: similar to Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7...	0.0	[2..943]	[1..1001]
gi\|31581595, gi\|... - ref\|NP_852658.1\| importin 7 [Mus musculus], gi\|11342591\|emb\|CAC17143.1\| RanBP7/importin 7 [Mus musc...	0.0	[2..943]	[1..1002]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..943]	[1..1001]
msk-PA - The gene moleskin is referred to in FlyBase by the symbol Dmel\msk (CG7935, FBgn0026252). It is a pr...	0.0	[2..943]	[1..1018]
SXM1 - Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucle... SXM1_YEAST - Importin beta SMX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SXM1 PE=1 SV=1	0.0	[1..944]	[1..944]
XPO2_PAGMA - Exportin-2 OS=Pagrus major GN=cse1l PE=2 SV=1	0.0	[3..941]	[7..966]

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Predicted Domain #1

Region A:
Residues: [1-254]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQEQAILSC IEQTMVADAK IIKEAEQQLF EFQKQPGFTS FLLNIVSDDN FALNVRLSSA  60
   61 IYLKNKIHRS WDTKREDGIK ADEKLSIKER LIETLVKNCE NNHIRPILTE TINGILVGQE 120
  121 DWDLAPIIKN LLSSGDASYI YPGLLLLFQL CKAHRWDMVG SRDYIDSVIE ELFPIVEGIA 180
  181 SNIGSQTDYR SNEILYLILK SFKYACLNNL PQYFSQPERI MSWVQLHLYL CSKPLPVEVM 240
  241 ELDPADRSLD KRVK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.69897
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
nuclear export signal receptor activity	2.13470398426489	bayes_pls_golite062009
cytoskeletal protein binding	1.97003189625955	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
signal transducer activity	1.51103985174196	bayes_pls_golite062009
molecular transducer activity	1.51103985174196	bayes_pls_golite062009
actin binding	1.4328432044371	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
RNA binding	1.20550543134698	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
nucleic acid binding	1.00841167631924	bayes_pls_golite062009
peptide binding	0.61212282188613	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
structural molecule activity	0.449804281824548	bayes_pls_golite062009
transcription regulator activity	0.385452858197632	bayes_pls_golite062009
mRNA binding	0.37278269424461	bayes_pls_golite062009
DNA binding	0.309260217284589	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
receptor binding	0.100410929582364	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
protein phosphatase binding	0.0960864951500202	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [255-484]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNKWGFGNLN RFLQRYNKIT KAITKEFIDY IFNTIVPIIL REFFKDIEAW GNNSLWLSDS  60
   61 SLYFLISFLE KCVTIDQLYP LIEPHLQIIF ENVIFPCLCA NEQSIELLED DQEEYTRRYF 120
  121 DINREGSTPD AASADFIFLI GSKRPEKLNN ILPFINDIFT RFDANSSDIN MAFKEEGALR 180
  181 TLSNLFSFID EPSVLENIFG HFIVPLLSQD KYMFLVARSL ETIALYSEEF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.69897
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [485-605]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDMNILSQLF ELTYTNFLNS NVLPVQIEAA DAIKCLIVSN PQIHPAVSAH VPGMMEKLLK  60
   61 LSKIFEIDIL SEVMEALVER FSDELSPFAK DLASNLVEQF LRIAQALVEN PSETYSASDQ 120
  121 E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.69897
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [606-795]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEIQASGLLQ TMTTMVMSMN KVPLIESLAP VVKFVVLHAQ ISFITEAVDL LDALTISSHL  60
   61 LYNQIAPPIW ELLHDILDSF QTYAMDYFEA YSIFFETIVM TGFPQDQTYV QPLLEILSAK 120
  121 LESEVDYDIE HVMQILMYFA LSMRDIPLFS KAIKVSTNDE LGLDSKCIVK LGLANLFAKP 180
  181 IETLQIMENE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.69897
Match:	1qgkA_
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [796-944]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFTINFFTNW FNEKFYSVFA IKLQVLVILT LLKMPEVPNS VSPLLNNLTN KLVELTLSLP  60
   61 KAIRNRDAVT EGKSLEGDLT PEEEEEYFIE CDDDMKETVL DQINVFQEVH TFFKNLQNED 120
  121 AGKYEKIINY LDESKRDSLQ VILEFVSQH

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: