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View Structure Prediction Details

Protein: GCN2
Organism: Saccharomyces cerevisiae
Length: 1659 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCN2.

Description E-value Query
Range
Subject
Range
gi|10764165 - gi|10764165|gb|AAG22591.1| GCN2gamma [Mus musculus]
0.0 [77..1648] [8..1562]
gi|3355628, gi|3... - gi|3355628|emb|CAA62973.1| CPC3 protein [Neurospora crassa], gi|32412400|ref|XP_326680.1| hypothetic...
gi|85103595 - gi|85103595|ref|XP_961553.1| hypothetical protein NCU01187 [Neurospora crassa OR74A]
0.0 [11..1657] [44..1644]
gi|171578, gi|121064 - gi|171578|gb|AAA34636.1| GCN2 [Saccharomyces cerevisiae], gi|121064|sp|P15442|GCN2_YEAST Serine/thre...
0.0 [70..1659] [1..1590]
gi|7243057 - gi|7243057|dbj|BAA92576.1| KIAA1338 protein [Homo sapiens]
0.0 [161..1648] [22..1487]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [9..1588] [8..1517]
Gcn2-PA, FBpp0306618 - The gene Gcn2 is referred to in FlyBase by the symbol Dmel\Gcn2 (CG1609, FBgn0019990). It is a prote...
0.0 [9..1588] [8..1517]

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Predicted Domain #1
Region A:
Residues: [1-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSHLTLDQ YYEIQCNELE AIRSIYMDDF TDLTKRKSSW DKQPQIIFEI TLRSVDKEPV  60
   61 ESSITLHFAM TPMYPYTAPE IEFKNVQNVM DSQLQMLKSE FKKIHNTSRG QEIIFEITSF 120
  121 TQEKLDEFQN VVNTQSLEDD RLQRIKETKE QLEKEEREKQ QETIKKRSDE QRRIDEIVQR 180
  181 ELEKRQDDDD DLLFNRTTQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
ligase activity 5.77046276233401 bayes_pls_golite062009
small conjugating protein ligase activity 3.65045022869763 bayes_pls_golite062009
ubiquitin-protein ligase activity 3.38582942748827 bayes_pls_golite062009
eukaryotic translation initiation factor 2alpha kinase activity 3.23512529981344 bayes_pls_golite062009
acid-amino acid ligase activity 2.62286563200644 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 2.4573066461497 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 2.4573066461497 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 2.44492491338365 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.69002970237151 bayes_pls_golite062009
kinase activity 1.63748693386705 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.47781099411385 bayes_pls_golite062009
binding 1.32417336730245 bayes_pls_golite062009
protein kinase activity 1.24946862508965 bayes_pls_golite062009
transferase activity 1.12000675735902 bayes_pls_golite062009
nucleic acid binding 1.07247161465191 bayes_pls_golite062009
transcription regulator activity 1.07160795075065 bayes_pls_golite062009
protein serine/threonine kinase activity 0.972449791105909 bayes_pls_golite062009
DNA binding 0.933974549145269 bayes_pls_golite062009
catalytic activity 0.891402822028799 bayes_pls_golite062009
protein binding 0.726328463755484 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.509761707991986 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [200-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLQPPSEWV ASGEAIVFSK TIKAKLPNNS MFKFKAVVNP KPIKLTSDIF SFSKQFLVKP  60
   61 YIPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.530 0.924 regulation of translational initiation a.144.1 PABC (PABP) domain
View Download 0.491 0.924 regulation of translational initiation a.138.1 Multiheme cytochromes
View Download 0.603 0.924 regulation of translational initiation a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.490 0.924 regulation of translational initiation a.4.11 RNA polymerase subunit RPB10
View Download 0.844 0.924 regulation of translational initiation a.144.2 Ribosomal protein L20
View Download 0.381 0.924 regulation of translational initiation a.17.1 p8-MTCP1
View Download 0.359 0.924 regulation of translational initiation a.4.5 "Winged helix" DNA-binding domain
View Download 0.345 0.924 regulation of translational initiation a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.345 0.924 regulation of translational initiation d.45.1 ClpS-like
View Download 0.331 0.924 regulation of translational initiation d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.315 0.924 regulation of translational initiation a.4.1 Homeodomain-like
View Download 0.306 0.924 regulation of translational initiation a.4.1 Homeodomain-like
View Download 0.302 0.924 regulation of translational initiation a.64.1 Saposin
View Download 0.302 0.924 regulation of translational initiation d.58.17 Metal-binding domain
View Download 0.298 0.924 regulation of translational initiation c.114.1 YchN-like
View Download 0.292 0.924 regulation of translational initiation d.58.11 EF-G/eEF-2 domains III and V
View Download 0.284 0.924 regulation of translational initiation a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.284 0.924 regulation of translational initiation a.35.1 lambda repressor-like DNA-binding domains
View Download 0.249 0.924 regulation of translational initiation a.39.1 EF-hand
View Download 0.248 0.924 regulation of translational initiation a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.244 0.924 regulation of translational initiation a.35.1 lambda repressor-like DNA-binding domains
View Download 0.241 0.924 regulation of translational initiation d.58.17 Metal-binding domain
View Download 0.236 0.924 regulation of translational initiation d.79.3 L30e-like
View Download 0.218 0.924 regulation of translational initiation a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.212 0.924 regulation of translational initiation a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.206 0.924 regulation of translational initiation d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.203 0.924 regulation of translational initiation a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #3
Region A:
Residues: [264-579]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESPLADFLMS SEMMENFYYL LSEIELDNSY FNTSNGKKEI ANLEKELETV LKAKHDNVNR  60
   61 LFGYTVERMG RNNATFVWKI RLLTEYCNYY PLGDLIQSVG FVNLATARIW MIRLLEGLEA 120
  121 IHKLGIVHKC INLETVILVK DADFGSTIPK LVHSTYGYTV LNMLSRYPNK NGSSVELSPS 180
  181 TWIAPELLKF NNAKPQRLTD IWQLGVLFIQ IISGSDIVMN FETPQEFLDS TSMDETLYDL 240
  241 LSKMLNNDPK KRLGTLELLP MKFLRTNIDS TINRFNLVSE SVNSNSLELT PGDTITVRGN 300
  301 GGRTLSQSSI RRRSFN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 160.626727
Match: 1pme__
Description: MAP kinase Erk2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
protein kinase activity 5.17195961442593 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
structural molecule activity 3.82327979736517 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 2.33015238923914 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 2.33015238923914 bayes_pls_golite062009
binding 2.31930216202447 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 2.31770167474216 bayes_pls_golite062009
ligase activity 2.15844649250746 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
eukaryotic translation initiation factor 2alpha kinase activity 1.09810837428564 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
transcription regulator activity 0.425540150205164 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.39973598464632 bayes_pls_golite062009
nucleic acid binding 0.398242700677703 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
DNA binding 0.331341423430082 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
RNA binding 0.245748631571068 bayes_pls_golite062009
transcription factor activity 0.151610605304256 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [580-702]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGSRFSSINP ATRSRYASDF EEIAVLGQGA FGQVVKARNA LDSRYYAIKK IRHTEEKLST  60
   61 ILSEVMLLAS LNHQYVVRYY AAWLEEDSMD ENVFESTDEE SDLSESSSDF EENDLLDQSS 120
  121 IFK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.201249
Match: 1lwpA_
Description: No description for 1lwpA_ was found.

Predicted Domain #5
Region A:
Residues: [703-800]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRTNHDLDNS NWDFISGSGY PDIVFENSSR DDENEDLDHD TSSTSSSESQ DDTDKESKSI  60
   61 QNVPRRRNFV KPMTAVKKKS TLFIQMEYCE NRTLYDLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.201249
Match: 1lwpA_
Description: No description for 1lwpA_ was found.

Predicted Domain #6
Region A:
Residues: [801-938]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSENLNQQRD EYWRLFRQIL EALSYIHSQG IIHRDLKPMN IFIDESRNVK IGDFGLAKNV  60
   61 HRSLDILKLD SQNLPGSSDN LTSAIGTAMY VATEVLDGTG HYNEKIDMYS LGIIFFEMIY 120
  121 PFSTGMERVN ILKKLRSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.201249
Match: 1lwpA_
Description: No description for 1lwpA_ was found.

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 7.89468709683036 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 7.89468709683036 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.88410036819636 bayes_pls_golite062009
ligase activity 6.92073480193262 bayes_pls_golite062009
histidine-tRNA ligase activity 5.91343220471745 bayes_pls_golite062009
phenylalanine-tRNA ligase activity 3.22631630581238 bayes_pls_golite062009
glycine-tRNA ligase activity 2.29229136935761 bayes_pls_golite062009
threonine-tRNA ligase activity 2.18642354927 bayes_pls_golite062009
serine-tRNA ligase activity 2.07594942154162 bayes_pls_golite062009
catalytic activity 1.99372273395202 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
lysine-tRNA ligase activity 1.72324031407565 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.43493514551266 bayes_pls_golite062009
binding 1.11470390774037 bayes_pls_golite062009
transferase activity 1.00944766864901 bayes_pls_golite062009
transcription regulator activity 0.936096346913383 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.921492123574877 bayes_pls_golite062009
nucleic acid binding 0.817940471445751 bayes_pls_golite062009
ATP binding 0.78849239804069 bayes_pls_golite062009
DNA binding 0.755075958424431 bayes_pls_golite062009
adenyl ribonucleotide binding 0.751370849162632 bayes_pls_golite062009
adenyl nucleotide binding 0.727917585848449 bayes_pls_golite062009
RNA binding 0.576453255038334 bayes_pls_golite062009
purine ribonucleotide binding 0.482944943143156 bayes_pls_golite062009
ribonucleotide binding 0.48293725802639 bayes_pls_golite062009
purine nucleotide binding 0.467088940808932 bayes_pls_golite062009
nucleotide binding 0.457991109108443 bayes_pls_golite062009
transcription factor activity 0.151651763713257 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.00572514744734753 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [939-1029]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIEFPPDFDD NKMKVEKKII RLLIDHDPNK RPGARTLLNS GWLPVKHQDE VIKEALKSLS  60
   61 NPSSPWQQQV RESLFNQSYS LTNDILFDNS V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 271.0
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1030-1062]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTSTPFANIL RSQMTEEVVK IFRKHGGIEN NAP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1093-1117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLTYPMARYL SKNPSLISKQ YRMQH

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [1134-1371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGEIDFDIIS KSSSESGFYD AESLKIIDEI LTVFPVFEKT NTFFILNHAD ILESVFNFTN  60
   61 IDKAQRPLVS RMLSQVGFAR SFKEVKNELK AQLNISSTAL NDLELFDFRL DFEAAKKRLY 120
  121 KLMIDSPHLK KIEDSLSHIS KVLSYLKPLE VARNVVISPL SNYNSAFYKG GIMFHAVYDD 180
  181 GSSRNMIAAG GRYDTLISFF ARPSGKKSSN TRKAVGFNLA WETIFGIAQN YFKLASGN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1httA_
Description: Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1063-1092]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRIFPKAPIY GTQNVYEVLD KGGTVLQLQY 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1118-1133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VYRPPDHSRS SLEPRK

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [1372-1517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIKKRNRFLK DTAVDWKPSR CDVLISSFSN SLLDTIGVTI LNTLWKQNIK ADMLRDCSSV  60
   61 DDVVTGAQQD GIDWILLIKQ QAYPLTNHKR KYKPLKIKKL STNVDIDLDL DEFLTLYQQE 120
  121 TGNKSLINDS LTLGDKADEF KRWDEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1httA_
Description: Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #10
Region A:
Residues: [1518-1659]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSAGSSQEGD IDDVVAGSTN NQKVIYVPNM ATRSKKANKR EKWVYEDAAR NSSNMILHNL  60
   61 SNAPIITVDA LRDETLEIIS ITSLAQKEEW LRKVFGSGNN STPRSFATSI YNNLSKEAHK 120
  121 GNRWAILYCH KTGKSSVIDL QR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.422 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.524 c.95.1 Thiolase-like
View Download 0.457 c.17.1 Caspase-like
View Download 0.498 d.142.1 Glutathione synthetase ATP-binding domain-like
View Download 0.434 c.95.1 Thiolase-like
View Download 0.359 c.52.1 Restriction endonuclease-like
View Download 0.348 c.95.1 Thiolase-like
View Download 0.324 a.77.1 DEATH domain
View Download 0.301 c.17.1 Caspase-like
View Download 0.281 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.239 c.28.1 Cryptochrome/photolyase, N-terminal domain
View Download 0.232 c.36.1 Thiamin diphosphate-binding fold (THDP-binding)
View Download 0.227 c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.227 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.221 d.54.1 Enolase N-terminal domain-like
View Download 0.219 c.47.1 Thioredoxin-like
View Download 0.218 c.28.1 Cryptochrome/photolyase, N-terminal domain
View Download 0.212 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.211 c.52.1 Restriction endonuclease-like
View Download 0.204 d.110.4 SNARE-like
View Download 0.201 c.95.1 Thiolase-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle