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View Structure Prediction Details

Protein: CMD1
Organism: Saccharomyces cerevisiae
Length: 147 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CMD1.

Description E-value Query
Range		 Subject
Range
CALM3_PETHY - Calmodulin-related protein OS=Petunia hybrida GN=CAM53 PE=2 SV=2
 6.0E-69 [1..145] [1..146]
gi|66360462, gi|... - gi|66360462|pdb|1XFU|T Chain T, Crystal Structure Of Anthrax Edema Factor (Ef) Truncation Mutant, Ef...
gi|14250065, gi|... - gi|66360530|pdb|1XFZ|T Chain T, Crystal Structure Of Anthrax Edema Factor (Ef) In Complex With Calmo...
 2.0E-67 [1..146] [1..147]
CALMB_HALRO - Calmodulin-B OS=Halocynthia roretzi PE=3 SV=3
 5.0E-67 [1..146] [1..147]
CALM_MYXGL - Calmodulin OS=Myxine glutinosa PE=2 SV=3
 6.0E-67 [1..146] [1..147]
gi|206814475 - gi|206814475|gb|ACI22622.1| calmodulin [Hyriopsis schlegelii]
gi|156066422 - gi|156066422|gb|ABU43070.1| calmodulin [Haliotis diversicolor]
gi|156399584, gi... - gi|156399584|ref|XP_001638581.1| predicted protein [Nematostella vectensis], gi|156225703|gb|EDO4651...
gi|169245993 - gi|169245993|gb|ACA51013.1| calmodulin [Acropora muricata]
CALM_METSE - Calmodulin OS=Metridium senile PE=1 SV=3
 6.0E-67 [1..146] [1..147]
CALM_CIOIN - Calmodulin OS=Ciona intestinalis PE=2 SV=3
 8.0E-67 [1..146] [1..147]
gi|89574499, gi|... - gi|89574499|gb|ABD76380.1| putative calmodulin [Acyrthosiphon pisum], gi|239789325|dbj|BAH71293.1| A...
gi|90819990 - gi|90819990|gb|ABD98752.1| putative calmodulin [Graphocephala atropunctata]
gi|91077856 - gi|91077856|ref|XP_972156.1| PREDICTED: similar to Calmodulin [Tribolium castaneum]
gi|94469010, gi|... - gi|94469010|gb|ABF18354.1| calmodulin [Aedes aegypti], gi|157167850|ref|XP_001662431.1| calmodulin [...
gi|198456512, gi... - gi|198456512|ref|XP_002138252.1| GA24499 [Drosophila pseudoobscura pseudoobscura], gi|198135639|gb|E...
gi|225711016, gi... - gi|225711016|gb|ACO11354.1| Calmodulin [Caligus rogercresseyi], gi|225709188|gb|ACO10440.1| Calmodul...
gi|195582657, gi... - gi|195582657|ref|XP_002081142.1| GD10849 [Drosophila simulans], gi|194193151|gb|EDX06727.1| GD10849 ...
gi|225717508 - gi|225717508|gb|ACO14600.1| Calmodulin [Caligus clemensi]
gi|220952894 - gi|220952894|gb|ACL88990.1| Cam-PA [synthetic construct]
gi|148907840 - gi|148907840|gb|ABR17044.1| unknown [Picea sitchensis]
gi|195333678, gi... - gi|195333678|ref|XP_002033513.1| GM21351 [Drosophila sechellia], gi|194125483|gb|EDW47526.1| GM21351...
gi|195149742, gi... - gi|195149742|ref|XP_002015815.1| GL10814 [Drosophila persimilis], gi|194109662|gb|EDW31705.1| GL1081...
Cam-PA, FBpp0293... - The gene Calmodulin is referred to in FlyBase by the symbol Dmel\Cam (CG8472, FBgn0000253). It is a ...
gi|194177199, gi... - gi|195485450|ref|XP_002091098.1| Cam [Drosophila yakuba], gi|194177199|gb|EDW90810.1| Cam [Drosophil...
gi|194162187, gi... - gi|195436292|ref|XP_002066102.1| GK22183 [Drosophila willistoni], gi|194162187|gb|EDW77088.1| GK2218...
gi|190620671, gi... - gi|194754178|ref|XP_001959373.1| GF12835 [Drosophila ananassae], gi|190620671|gb|EDV36195.1| GF12835...
cds.comp127688_c... - comp127688_c0_seq1|g.15711 ORF comp127688_c0_seq1|g.15711 comp127688_c0_seq1|m.15711 type:complete ...
gi|167863843, gi... - gi|170067797|ref|XP_001868623.1| calmodulin [Culex quinquefasciatus], gi|167863843|gb|EDS27226.1| ca...
gi|195122340, gi... - gi|195122340|ref|XP_002005669.1| GI20594 [Drosophila mojavensis], gi|193910737|gb|EDW09604.1| GI2059...
gi|194883730, gi... - gi|194883730|ref|XP_001975954.1| GG20265 [Drosophila erecta], gi|190659141|gb|EDV56354.1| GG20265 [D...
gi|51557667 - gi|51557667|gb|AAU06473.1| calmodulin [Culicoides sonorensis]
gi|155966153, gi... - gi|225712868|gb|ACO12280.1| Calmodulin [Lepeophtheirus salmonis], gi|155966153|gb|ABU41031.1| calmod...
gi|156547856 - gi|156547856|ref|XP_001606310.1| PREDICTED: similar to Calmodulin [Nasonia vitripennis]
gi|114052252, gi... - gi|87248465|gb|ABD36285.1| calmodulin [Bombyx mori], gi|114052252|ref|NP_001040234.1| calmodulin [Bo...
gi|66538476 - gi|66538476|ref|XP_624247.1| PREDICTED: similar to Calmodulin CG8472-PA, isoform A [Apis mellifera]
gi|115699900, gi... - gi|115978398|ref|XP_001177697.1| PREDICTED: similar to ENSANGP00000012700 isoform 1 [Strongylocentro...
gi|119351147 - gi|119351147|gb|AAQ01510.2| calmodulin [Branchiostoma belcheri tsingtauense]
gi|20152221 - gi|20152221|dbj|BAB89360.1| calmodulin [Strongylocentrotus intermedius]
CALM1_BRAFL - Calmodulin-1 OS=Branchiostoma floridae PE=2 SV=2
CALM1_BRALA - Calmodulin-1 OS=Branchiostoma lanceolatum PE=2 SV=2
CALMA_HALRO - Calmodulin-A OS=Halocynthia roretzi PE=1 SV=2
CALM_LOCMI - Calmodulin OS=Locusta migratoria PE=1 SV=2
CALM_APLCA - Calmodulin OS=Aplysia californica GN=CAM PE=2 SV=2
gi|52630951 - gi|52630951|gb|AAU84939.1| putative calmodulin [Toxoptera citricida]
 9.0E-67 [1..146] [1..147]
gi|12851157 - gi|12851157|dbj|BAB28959.1| unnamed protein product [Mus musculus]
 1.0E-66 [1..146] [1..147]
CALM_STIJA - (P21251) Calmodulin (CaM)
 1.0E-66 [2..146] [1..146]

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Predicted Domain #1
Region A:
Residues: [1-77] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNLTEEQI AEFKEAFALF DKDNNGSISS SELATVMRSL GLSPSEAEVN DLMNEIDVDG  60
   61 NHQIEFSEFL ALMSRQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 481.67837
Match: 1iq5A_
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
troponin T binding 7.68526659589559 bayes_pls_golite062009
phosphoprotein phosphatase activity 7.47426847861728 bayes_pls_golite062009
protein serine/threonine phosphatase activity 6.37104157544514 bayes_pls_golite062009
structural constituent of muscle 6.34041234021534 bayes_pls_golite062009
actin-dependent ATPase activity 6.31366142616096 bayes_pls_golite062009
phosphatase activity 6.28157965296365 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.17799259119197 bayes_pls_golite062009
N-terminal myristoylation domain binding 5.746886320739 bayes_pls_golite062009
microfilament motor activity 5.62061944255026 bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity 5.58369939851095 bayes_pls_golite062009
G-protein beta/gamma-subunit binding 5.51712867097471 bayes_pls_golite062009
myosin II heavy chain binding 5.49688740358168 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.11186887221409 bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase regulator activity 4.70715233640875 bayes_pls_golite062009
actin binding 3.96919556235483 bayes_pls_golite062009
calcium ion binding 3.79609619542776 bayes_pls_golite062009
myosin heavy chain binding 3.63014173976595 bayes_pls_golite062009
cytoskeletal protein binding 3.49668552859347 bayes_pls_golite062009
motor activity 3.25814691068414 bayes_pls_golite062009
binding 3.17556402087346 bayes_pls_golite062009
cation binding 2.62077305565026 bayes_pls_golite062009
metal ion binding 2.62077305565026 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.61874575467092 bayes_pls_golite062009
ion binding 2.61312132078717 bayes_pls_golite062009
ion transmembrane transporter activity 2.57032504567157 bayes_pls_golite062009
cation transmembrane transporter activity 2.55650624542181 bayes_pls_golite062009
tubulin binding 2.51210014078446 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37465721152046 bayes_pls_golite062009
actin filament binding 2.35534489389161 bayes_pls_golite062009
myosin binding 2.34125070430971 bayes_pls_golite062009
calcium sensitive guanylate cyclase activator activity 2.25146252368284 bayes_pls_golite062009
protein binding 2.21291432166051 bayes_pls_golite062009
microtubule binding 2.17136406283012 bayes_pls_golite062009
structural molecule activity 2.02132683356917 bayes_pls_golite062009
transcription regulator activity 1.82714164083189 bayes_pls_golite062009
signal transducer activity 1.56751504958972 bayes_pls_golite062009
molecular transducer activity 1.56751504958972 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.51057181410195 bayes_pls_golite062009
cation channel activity 1.49312394054212 bayes_pls_golite062009
kinase activity 1.48008348280256 bayes_pls_golite062009
nucleic acid binding 1.43263098461462 bayes_pls_golite062009
DNA binding 1.40714762620388 bayes_pls_golite062009
hydrolase activity 1.35435291164259 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.34982153616582 bayes_pls_golite062009
peptidase activity 1.33558871501581 bayes_pls_golite062009
clathrin binding 1.25585696981668 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
passive transmembrane transporter activity 1.05847414989139 bayes_pls_golite062009
channel activity 1.05847414989139 bayes_pls_golite062009
ion channel activity 1.0369591011376 bayes_pls_golite062009
substrate-specific channel activity 1.03529144716694 bayes_pls_golite062009
transferase activity 1.00143834284844 bayes_pls_golite062009
actin monomer binding 0.9954841049256 bayes_pls_golite062009
voltage-gated cation channel activity 0.986621437232479 bayes_pls_golite062009
nitric-oxide synthase binding 0.965098383344279 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.956941988596969 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
voltage-gated ion channel activity 0.910148857310729 bayes_pls_golite062009
potassium channel activity 0.906643355854798 bayes_pls_golite062009
voltage-gated channel activity 0.896351900356978 bayes_pls_golite062009
phosphatase regulator activity 0.87149881541475 bayes_pls_golite062009
gated channel activity 0.855502499003241 bayes_pls_golite062009
cyclase regulator activity 0.84389905735679 bayes_pls_golite062009
guanylate cyclase regulator activity 0.84389905735679 bayes_pls_golite062009
protein phosphatase regulator activity 0.822713961141111 bayes_pls_golite062009
voltage-gated potassium channel activity 0.810245330492755 bayes_pls_golite062009
calcium channel regulator activity 0.7164851905066 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
peptide binding 0.3862375622127 bayes_pls_golite062009
0.34446792626966 bayes_pls_golite062009
channel regulator activity 0.32809521759917 bayes_pls_golite062009
myosin II binding 0.311147527050891 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
ER retention sequence binding 0.234166588492671 bayes_pls_golite062009
structural constituent of cytoskeleton 0.116648335890738 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [78-147] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSNDSEQELL EAFKVFDKNG DGLISAAELK HVLTSIGEKL TDAEVDDMLR EVSDGSGEIN  60
   61 IQQFAALLSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 481.67837
Match: 1iq5A_
Description: Calmodulin
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle