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View Structure Prediction Details

Protein: nas-23
Organism: Caenorhabditis elegans
Length: 537 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nas-23.

Description E-value Query
Range
Subject
Range
gi|157750650 - gi|157750650|ref|XP_001679037.1| Hypothetical protein CBG13043 [Caenorhabditis briggsae AF16]
gi|39596019, gi|... - gi|39596019|emb|CAE67522.1| Hypothetical protein CBG13043 [Caenorhabditis briggsae], gi|187029048|em...
363.0 [0..1] [537..1]

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Predicted Domain #1
Region A:
Residues: [1-104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLILVLAG SIGIYGVNLP KIPKLSDLVN PFQQFKLKDI LSTLTALDTP DIAADSAGVS  60
   61 LPKHEYTDRL SSISDLNRSK RDLLFQGDIH LSFEHLSNIV REQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [105-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHSRTKRTAF RNAMYPKTIW LPNVPFELHG SLSAKSRSSL VAAMAFWEKH TCVAFKKRTS  60
   61 EKVYLLMSGQ EEGCWSTVGR DEAQGAQILN IGTGCEMFGI TSHEIAHALG LFHEQSRYDR 120
  121 DNYVQIVKSR IAQTNFYDFA VVGKKNMETY GQKYDIGSVM HYRPTEFSLD GGNSIIAKDV 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.69897
Match: 1astA
Description: STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.1917763812737 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.85190688399485 bayes_pls_golite062009
metallopeptidase activity 3.22757426039234 bayes_pls_golite062009
endopeptidase activity 2.98133341931091 bayes_pls_golite062009
hydrolase activity 2.78513171530601 bayes_pls_golite062009
metalloendopeptidase activity 2.54952091441017 bayes_pls_golite062009
transporter activity 1.28982382930122 bayes_pls_golite062009
binding 1.19918194301835 bayes_pls_golite062009
transmembrane transporter activity 1.0688261398267 bayes_pls_golite062009
catalytic activity 0.891187593353827 bayes_pls_golite062009
substrate-specific transporter activity 0.798767221679673 bayes_pls_golite062009
protein binding 0.553658909577001 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.543737159152136 bayes_pls_golite062009
exopeptidase activity 0.492456025063956 bayes_pls_golite062009
receptor activity 0.332822250208465 bayes_pls_golite062009
ion transmembrane transporter activity 0.241890854867053 bayes_pls_golite062009
transmembrane receptor activity 0.136560284009247 bayes_pls_golite062009
integrin binding 0.0945964646680701 bayes_pls_golite062009
aminopeptidase activity 0.00533877867882504 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [285-355]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NMQNTMGQFR GPSFIDVAKI NRHYNCEKNC KNKITCLNGG YQHPKNCKIC VCPPGYGGSD  60
   61 CKGIEASSPA K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [356-537]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CTGVLVAGET QRKFTANIKP NKNAKGIRKC NYHIEAPPGK RIVIIVDSVI GNCVQGCYEE  60
   61 GVELKMYEDK TVTGARFCCK LQKPQTLISQ GNTVPLMLVA GKAQAFVQLR YSTVDGPQNR 120
  121 SPKDGNATSI GVNPFLLEKY QDNSIDSEAI RKEYHIQSDN VNQEDFETLV RSEFIDENTA 180
  181 DI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1nt0A
Description: Mannose-binding protein associated serine protease 2, MASP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.19152785302602 bayes_pls_golite062009
peptidase activity 2.03786631670095 bayes_pls_golite062009
protein binding 1.99839937208979 bayes_pls_golite062009
receptor binding 1.94948331803509 bayes_pls_golite062009
transporter activity 1.35573169203175 bayes_pls_golite062009
receptor activity 1.17703206127603 bayes_pls_golite062009
hydrolase activity 1.12447587972667 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.10435298721188 bayes_pls_golite062009
ErbB-2 class receptor binding 1.03966651045249 bayes_pls_golite062009
endopeptidase activity 1.03668892056053 bayes_pls_golite062009
ErbB-3 class receptor binding 1.02450424977847 bayes_pls_golite062009
epidermal growth factor receptor binding 0.71787375735636 bayes_pls_golite062009
metallopeptidase activity 0.623476257655953 bayes_pls_golite062009
metalloendopeptidase activity 0.508669171144608 bayes_pls_golite062009
transcription factor binding 0.30492109086541 bayes_pls_golite062009
growth factor activity 0.190406928940325 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle