YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30265042, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	316 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30265042, gi|....

Description	E-value	Query Range	Subject Range
gi\|67968888 - gi\|67968888\|dbj\|BAE00801.1\| unnamed protein product [Macaca fascicularis] gi\|109107092 - gi\|109107092\|ref\|XP_001084747.1\| PREDICTED: lactate dehydrogenase A isoform 6 [Macaca mulatta]	4.0E-95	[4..316]	[48..361]
gi\|73988677 - gi\|73988677\|ref\|XP_534084.2\| PREDICTED: similar to L-lactate dehydrogenase A chain (LDH-A) (LDH musc...	9.0E-95	[4..316]	[48..361]
gi\|17368677, gi\|... - gi\|17368677\|sp\|Q9BE24\|LDHA_MACFA L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M...	2.0E-94	[4..316]	[19..332]
LDHA_PONAB - L-lactate dehydrogenase A chain OS=Pongo abelii GN=LDHA PE=2 SV=3 LDHA_PONPY - L-lactate dehydrogenase A chain - Pongo pygmaeus (Orangutan)	3.0E-94	[4..316]	[19..332]
gi\|55249958 - gb\|AAH86251.1\| Unknown (protein for MGC:98768) [Xenopus laevis] LDHA_MOUSE - L-lactate dehydrogenase A chain OS=Mus musculus GN=Ldha PE=1 SV=3	4.0E-94	[4..316]	[19..332]
LDHA_RAT - L-lactate dehydrogenase A chain OS=Rattus norvegicus GN=Ldha PE=1 SV=1	5.0E-94	[3..316]	[18..332]
LDHA - lactate dehydrogenase A	6.0E-94	[4..316]	[18..331]

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Predicted Domain #1

Region A:
Residues: [1-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRHTRKIAI IGTGLVGSSC AYSIVNQGIC EELLLIDINH ERAVGEAMDL SHCINFTNTR  60
   61 TKVYAGSYED CKDMDIVIIT AGPAPKPGQS RLDTLGASAK IMESVVGGVM ESGFDGIFLL 120
  121 ASNPVDIITY QVWKLSGLPR NRVIGTGTSL DSSRLRTILS EMLHVDPRSI HGYSLGEHGD 180
  181 SQMVAWSHVT VGGKPILQIL EEQKERFGEI DLDEIVEKTA KAGWEIYKRK GTTYYGIGNS 240
  241 LAYIASSIFN DDHRVIAVSA ILDGEYGEYD ICTGVPAIIT RDGIREIVEL NLTEDEESRF 300
  301 AKSNDILRDY MKTIGY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.0
Match:	1ldbA
Description:	STRUCTURE DETERMINATION AND REFINEMENT OF BACILLUS STEAROTHERMOPHILUS LACTATE DEHYDROGENASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
malate dehydrogenase activity	7.69241456337154	bayes_pls_golite062009
L-malate dehydrogenase activity	5.35837481826138	bayes_pls_golite062009
lactate dehydrogenase activity	4.66418715735914	bayes_pls_golite062009
malic enzyme activity	2.98382582538724	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
oxidoreductase activity	2.75947908917144	bayes_pls_golite062009
L-lactate dehydrogenase activity	2.59062377380589	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.58076782195922	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.88605255677599	bayes_pls_golite062009
binding	1.76718756313666	bayes_pls_golite062009
catalytic activity	1.67029398049886	bayes_pls_golite062009
protein binding	1.47646217957458	bayes_pls_golite062009
NAD or NADH binding	1.32276254629683	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.22444609393125	bayes_pls_golite062009
retinol dehydrogenase activity	1.16811519855038	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.91702493082811	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.788034697021177	bayes_pls_golite062009
fatty acid synthase activity	0.714637370305282	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.621273823467575	bayes_pls_golite062009
coenzyme binding	0.59785037604907	bayes_pls_golite062009
DNA binding	0.525227236870065	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.523513694229008	bayes_pls_golite062009
nucleic acid binding	0.459537641913493	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.216422278300306	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.19685680097448	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.192594057004213	bayes_pls_golite062009
transcription regulator activity	0.177044638410302	bayes_pls_golite062009
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity	0.120195861875768	bayes_pls_golite062009
signal transducer activity	0.0433763403499039	bayes_pls_golite062009
molecular transducer activity	0.0433763403499039	bayes_pls_golite062009
formate dehydrogenase activity	4.92199819939532E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: