YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24346031, gi\|...
Organism:	Shewanella oneidensis MR-1
Length:	717 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24346031, gi|....

Description	E-value	Query Range	Subject Range
gi\|78684296, gi\|... - gi\|78684296\|ref\|ZP_00849081.1\| PAS [Shewanella sp. ANA-3], gi\|78508048\|gb\|EAP21556.1\| PAS [Shewanell...	357.0	[0..1]	[717..1]
gi\|78688603, gi\|... - gi\|78688603\|ref\|ZP_00853271.1\| PAS [Shewanella sp. MR-7], gi\|78511984\|gb\|EAP25338.1\| PAS [Shewanella...	356.0	[0..1]	[717..1]
gi\|82495436, gi\|... - gi\|82495436\|ref\|ZP_00881012.1\| PAS [Shewanella sp. MR-4], gi\|82406620\|gb\|EAP47284.1\| PAS [Shewanella...	351.0	[0..1]	[717..1]
gi\|68520688, gi\|... - gi\|68541629\|ref\|ZP_00581371.1\| PAS [Shewanella baltica OS155], gi\|68520688\|gb\|EAN44190.1\| PAS [Shewa...	346.0	[0..1]	[715..1]
gi\|160862574, gi... - gi\|160877052\|ref\|YP_001556368.1\| multi-sensor signal transduction histidine kinase [Shewanella balti...	346.0	[0..1]	[715..1]
gi\|77811082, gi\|... - gi\|77813837\|ref\|ZP_00813108.1\| PAS [Shewanella putrefaciens CN-32], gi\|77811082\|gb\|EAO95456.1\| PAS [... gi\|124544888, gi... - gi\|124544888\|ref\|ZP_01704136.1\| multi-sensor signal transduction histidine kinase [Shewanella putref... gi\|120597442, gi... - gi\|120597442\|ref\|YP_962016.1\| multi-sensor signal transduction histidine kinase [Shewanella sp. W3-1...	345.0	[0..1]	[717..1]
gi\|82721212, gi\|... - gi\|82741468\|ref\|ZP_00904189.1\| PAS [Shewanella sp. W3-18-1], gi\|82721212\|gb\|EAP56057.1\| PAS [Shewane...	315.0	[0..74]	[717..1]
gi\|68546437, gi\|... - gi\|68546437\|ref\|ZP_00585984.1\| PAS [Shewanella amazonensis SB2B], gi\|68515851\|gb\|EAN39565.1\| PAS [Sh...	305.0	[0..29]	[716..2]
gi\|32446423, gi\|... - gi\|32475880\|ref\|NP_868874.1\| signal-transducing histidine kinase [Rhodopirellula baltica SH 1], gi\|3...	282.0	[0..8]	[712..4]
gi\|20090134, gi\|... - gi\|20090134\|ref\|NP_616209.1\| sensory transduction histidine kinase [Methanosarcina acetivorans C2A],...	280.0	[0..129]	[708..851]

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Predicted Domain #1

Region A:
Residues: [1-323]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTDRFPESF GPPKSFFISV VRSSWLMLVA ALTFMGISWF VLQEYLRERG EERFNNNVQE  60
   61 LSEAVSRRMT AYEQVLRGGV GLFLSSRGVT RSEWQTYVAN ARLSDYYPGI QGLGFAELVT 120
  121 PATLDEFTQQ VQQEGFSDFR ITPIGDRELY CVIKYLEPFD WRNQRAFGFD MCSEATRRSA 180
  181 ILKAITSGLP KVSGKVTLVQ ETPENTQAGV LMYVPLYRGQ PMTEVERMQQ AIGVVYALFR 240
  241 MNDLMQGIMG KRFSGIKLAI YDGSEANRTH LMFSSDPKLP SSKDVFYQSQ LETMEGQVWR 300
  301 IDVSSESRFI SRAEQTRSVW LQV

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.04
Match:	2p7jA
Description:	No description for 2p7jA was found.

Predicted functions:

Term	Confidence	Notes
two-component sensor activity	2.88093868237858	bayes_pls_golite062009
protein histidine kinase activity	2.86151216540335	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.80671328721504	bayes_pls_golite062009
protein kinase activity	1.74105675066805	bayes_pls_golite062009
two-component response regulator activity	1.62873572477094	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.58981311381645	bayes_pls_golite062009
kinase activity	1.5133458700147	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.31628115739307	bayes_pls_golite062009
signal transducer activity	1.10204821596482	bayes_pls_golite062009
molecular transducer activity	1.10204821596482	bayes_pls_golite062009
catalytic activity	0.970922685016416	bayes_pls_golite062009
transferase activity	0.839270468560673	bayes_pls_golite062009
binding	0.704248066961418	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [324-478]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGCAFILALF YAVISMARNR YQESMLTAEL IANEKRFRLI IEASPSALFM VDKTGVITLV  60
   61 NTQGERLFGY TREELLGRSI NMLLPETLRE IHQQHLSHYL VHPIAKNMSM RDDLLGCCKD 120
  121 GTPLAVEVGL TPVHFSNGIY ILTTINNISE RKRIE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.69897
Match:	1d06A
Description:	Histidine kinase FixL heme domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ion transmembrane transporter activity	1.94020112661684	bayes_pls_golite062009
transcription regulator activity	1.88422125389203	bayes_pls_golite062009
binding	1.79230776794479	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.70629448457771	bayes_pls_golite062009
cation transmembrane transporter activity	1.55042643398568	bayes_pls_golite062009
DNA binding	1.54206275665781	bayes_pls_golite062009
two-component response regulator activity	1.45691562840107	bayes_pls_golite062009
nucleic acid binding	1.41817054839611	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.31850321187865	bayes_pls_golite062009
transcription factor activity	1.12946889905444	bayes_pls_golite062009
protein binding	1.0133195984081	bayes_pls_golite062009
potassium channel activity	0.93265112299626	bayes_pls_golite062009
voltage-gated ion channel activity	0.92661046549451	bayes_pls_golite062009
voltage-gated cation channel activity	0.926512767264521	bayes_pls_golite062009
voltage-gated potassium channel activity	0.92204538811959	bayes_pls_golite062009
voltage-gated channel activity	0.91469735366704	bayes_pls_golite062009
ion channel activity	0.75430461252947	bayes_pls_golite062009
cation channel activity	0.73262554730695	bayes_pls_golite062009
gated channel activity	0.67217953143815	bayes_pls_golite062009
substrate-specific channel activity	0.650205954115699	bayes_pls_golite062009
passive transmembrane transporter activity	0.64202076714636	bayes_pls_golite062009
channel activity	0.64202076714636	bayes_pls_golite062009
two-component sensor activity	0.58151911764083	bayes_pls_golite062009
protein histidine kinase activity	0.56538125817883	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	0.518111391350209	bayes_pls_golite062009
signal transducer activity	0.441034662376355	bayes_pls_golite062009
molecular transducer activity	0.441034662376355	bayes_pls_golite062009
transporter activity	0.360938622392148	bayes_pls_golite062009
catalytic activity	0.285447488878019	bayes_pls_golite062009
transcription factor binding	0.24293756478811	bayes_pls_golite062009
transmembrane transporter activity	0.217804199010847	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [479-717]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQRIEHMAEL ERINQELDRF AYIASHDLKS PLRGIEQLTT WLSEDLVDNT NENVQKYLGL  60
   61 IQNRIQRMVR LLDGLLTFSR IGRVDNEMVE VDSRQLVEDM FALVAPPQGF ELVLEGDFPH 120
  121 FKTVKTLLEL VVRNLISNAI KHHDRGFGVL KVLCETKNTY YWFSVVDDGP GISSEFQLKV 180
  181 FEMFQTLRPR DEVEGSGLGL SLVKKTVDSL GGKIQLESVG RGCCFRFSWP IHIVNKEGI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.39794
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: