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View Structure Prediction Details

Protein: PRP2_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 876 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP2_YEAST.

Description E-value Query
Range
Subject
Range
PRP2_YEAST - Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 OS=Saccharomyces cerevisiae (s...
PRP2 - RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the f...
0.0 [1..876] [1..876]
gi|168275648 - gi|168275648|dbj|BAG10544.1| ATP-dependent RNA helicase DHX8 [synthetic construct]
DHX8 - DEAH (Asp-Glu-Ala-His) box polypeptide 8
gi|114666955 - gi|114666955|ref|XP_001154202.1| PREDICTED: DEAH (Asp-Glu-Ala-His) box polypeptide 8 isoform 5 [Pan ...
0.0 [5..876] [380..1194]
mog-5 - RNA helicase status:Confirmed UniProt:Q09530 protein_id:AAC46765.1
0.0 [15..876] [362..1169]
l(2)37Cb-PA - The gene lethal (2) 37Cb is referred to in FlyBase by the symbol Dmel\l(2)37Cb (CG10689, FBgn0086444...
0.0 [6..875] [28..882]
gi|14318701, gi|... - gi|30794426|ref|NP_081263.1| DEAH (Asp-Glu-Ala-His) box polypeptide 16 [Mus musculus], gi|223460667|...
0.0 [6..875] [176..1031]
ESP3_ARATH - Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1 OS=Arabidopsis thaliana GN=ESP3 PE=1 SV=1
0.0 [5..875] [163..1034]
PRP22_SCHPO - Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 OS=Schizosaccharomyces pombe (strain 972 /...
prp22 - ATP-dependent RNA helicase Prp22
0.0 [15..876] [331..1141]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSITSETGK RRVKRTYEVT RQNDNAVRIE PSSLGEEEDK EAKDKNSALQ LKRSRYDPNK  60
   61 VFSNTNQGPE KNNLKGEQLG SQKKSSKYDE KITSNNELTT KKGLLGDSEN ETKYASSNSK 120
  121 FNVEVTHKIK NAKEIDKINR QRMWEEQQLR NAMAGQSDHP DDITL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [166-600]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGSDKYDYVF DTDAMIDYTN EEDDLLPEEK LQYEARLAQA LETEEKRILT IQEARKLLPV  60
   61 HQYKDELLQE IKKNQVLIIM GETGSGKTTQ LPQYLVEDGF TDQGKLQIAI TQPRRVAATS 120
  121 VAARVADEMN VVLGKEVGYQ IRFEDKTTPN KTVLKYMTDG MLLREFLTDS KLSKYSCIMI 180
  181 DEAHERTLAT DILIGLLKDI LPQRPTLKLL ISSATMNAKK FSEFFDNCPI FNVPGRRYPV 240
  241 DIHYTLQPEA NYIHAAITTI FQIHTTQSLP GDILVFLTGQ EEIERTKTKL EEIMSKLGSR 300
  301 TKQMIITPIY ANLPQEQQLK IFQPTPENCR KVVLATNIAE TSLTIDGIRY VIDPGFVKEN 360
  361 SYVPSTGMTQ LLTVPCSRAS VDQRAGRAGR VGPGKCFRIF TKWSYLHELE LMPKPEITRT 420
  421 NLSNTVLLLL SLGVT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.09691
Match: 1fuuA_
Description: Initiation factor 4a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4.704140727858 bayes_pls_golite062009
binding 2.44689197844883 bayes_pls_golite062009
RNA binding 2.29590582680214 bayes_pls_golite062009
structural constituent of ribosome 1.57653963868443 bayes_pls_golite062009
RNA helicase activity 1.42791449104435 bayes_pls_golite062009
nucleic acid binding 1.41477043612798 bayes_pls_golite062009
RNA-dependent ATPase activity 1.39335733374328 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.36724390116598 bayes_pls_golite062009
DNA binding 1.11699929651302 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription regulator activity 0.989226939888218 bayes_pls_golite062009
mRNA binding 0.76699944561918 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.652333406433794 bayes_pls_golite062009
helicase activity 0.6191010101321 bayes_pls_golite062009
motor activity 0.61636596887462 bayes_pls_golite062009
structural molecule activity 0.596382945962261 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.461763181659193 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.458831409927227 bayes_pls_golite062009
pyrophosphatase activity 0.455976987338331 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.422944846459286 bayes_pls_golite062009
snRNA binding 0.418985924846052 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
ATP-dependent helicase activity 0.29664013896754 bayes_pls_golite062009
translation release factor activity 0.178286731022211 bayes_pls_golite062009
translation termination factor activity 0.151456842619444 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
transcription factor activity 0.0434163635422169 bayes_pls_golite062009
cytoskeletal protein binding 0.0272673919333979 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [601-697]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLIKFPLMDK PSIPTLRKSL ENLYILGALN SKGTITRLGK MMCEFPCEPE FAKVLYTAAT  60
   61 HEQCQGVLEE CLTIVSMLHE TPSLFIGQKR DAAASVL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.762 0.239 pre-mRNA splicing factor activity a.39.1 EF-hand
View Download 0.889 0.073 pre-mRNA splicing factor activity a.118.1 ARM repeat
View Download 0.763 0.029 nucleus a.74.1 Cyclin-like
View Download 0.703 0.003 nucleus a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.842 0.003 pre-mRNA splicing factor activity a.118.11 Cytochrome c oxidase subunit E
View Download 0.612 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.497 N/A N/A a.77.1 DEATH domain
View Download 0.485 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.465 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.459 N/A N/A a.39.1 EF-hand
View Download 0.446 N/A N/A e.37.1 Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
View Download 0.433 N/A N/A c.47.1 Thioredoxin-like
View Download 0.432 N/A N/A a.11.2 Second domain of FERM
View Download 0.419 N/A N/A a.83.1 Guanido kinase N-terminal domain
View Download 0.406 N/A N/A a.29.2 Bromodomain
View Download 0.378 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.377 N/A N/A a.39.1 EF-hand
View Download 0.372 N/A N/A a.118.1 ARM repeat
View Download 0.366 N/A N/A d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.362 N/A N/A a.1.1 Globin-like
View Download 0.353 N/A N/A a.74.1 Cyclin-like
View Download 0.348 N/A N/A a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.346 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.335 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.330 N/A N/A a.46.1 Methionine synthase domain
View Download 0.329 N/A N/A a.77.1 DEATH domain
View Download 0.324 N/A N/A a.39.1 EF-hand
View Download 0.324 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.319 N/A N/A a.77.1 DEATH domain
View Download 0.300 N/A N/A a.74.1 Cyclin-like
View Download 0.299 N/A N/A a.118.8 TPR-like
View Download 0.297 N/A N/A a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.295 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.292 N/A N/A c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.289 N/A N/A c.114.1 YchN-like
View Download 0.284 N/A N/A a.50.1 Anaphylotoxins (complement system)
View Download 0.280 N/A N/A d.58.17 Metal-binding domain
View Download 0.275 N/A N/A d.58.14 Ribosomal protein S6
View Download 0.275 N/A N/A a.3.1 Cytochrome c
View Download 0.274 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.274 N/A N/A d.58.27 Translational regulator protein regA
View Download 0.263 N/A N/A a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.262 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.261 N/A N/A d.58.48 MTH1187-like
View Download 0.260 N/A N/A d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.259 N/A N/A a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.259 N/A N/A a.74.1 Cyclin-like
View Download 0.242 N/A N/A d.58.5 GlnB-like
View Download 0.242 N/A N/A a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.240 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.240 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.237 N/A N/A a.97.1 An anticodon-binding domain of class I aminoacyl-tRNA synthetases
View Download 0.236 N/A N/A a.68.1 Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
View Download 0.235 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.233 N/A N/A a.1.1 Globin-like
View Download 0.233 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.233 N/A N/A a.43.1 Met repressor-like
View Download 0.232 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.231 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.225 N/A N/A c.98.2 HPr kinase/phoshatase HprK N-terminal domain
View Download 0.222 N/A N/A a.85.1 Hemocyanin, N-terminal domain
View Download 0.220 N/A N/A c.15.1 BRCT domain
View Download 0.219 N/A N/A d.15.2 CAD & PB1 domains
View Download 0.218 N/A N/A a.60.12 DNA polymerase beta-like, second domain
View Download 0.218 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.218 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.217 N/A N/A a.11.2 Second domain of FERM
View Download 0.216 N/A N/A a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.212 N/A N/A d.58.49 YajQ-like
View Download 0.210 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.209 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.206 N/A N/A a.28.2 Colicin E immunity proteins
View Download 0.204 N/A N/A d.50.3 PI-Pfui intein middle domain
View Download 0.204 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.203 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.201 N/A N/A a.118.1 ARM repeat

Predicted Domain #4
Region A:
Residues: [698-876]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEVESDHILY LEIFNQWRNS KFSRSWCQDH KIQFKTMLRV RNIRNQLFRC SEKVGLVEKN  60
   61 DQARMKIGNI AGYINARITR CFISGFPMNI VQLGPTGYQT MGRSSGGLNV SVHPTSILFV 120
  121 NHKEKAQRPS KYVLYQQLML TSKEFIRDCL VIPKEEWLID MVPQIFKDLI DDKTNRGRR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle