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View Structure Prediction Details

Protein: Ada2b-PB
Organism: Drosophila melanogaster
Length: 555 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ada2b-PB.

Description E-value Query
Range		 Subject
Range
gi|39940282, gi|... - gi|39940282|ref|XP_359678.1| hypothetical protein MGG_05099 [Magnaporthe grisea 70-15], gb|EAA52407....
 263.0 [0..2] [555..10]

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Predicted Domain #1
Region A:
Residues: [1-63] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTIADLFTK YNCTNCQDDI QGIRVHCAEC ENFDLCLQCF AAGAEIGAHQ NNHSYQFMDT  60
   61 GTS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.87
Match: 2e5rA
Description: No description for 2e5rA was found.

Predicted Domain #2
Region A:
Residues: [64-178] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILSVFRGKGA WTAREEIRLL DAIEQYGFGN WEDISKHIET KSAEDAKEEY VNKFVNGTIG  60
   61 RATWTPAQSQ RPRLIDHTGD DDAGPLGTNA LSTLPPLEIN SDEAMQLGYM PNRDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.221849
Match: 1h88C
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
histone acetyltransferase activity 5.80609397811031 bayes_pls_golite062009
lysine N-acetyltransferase activity 5.80609397811031 bayes_pls_golite062009
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
N-acyltransferase activity 4.57418118498868 bayes_pls_golite062009
N-acetyltransferase activity 4.37954729923498 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
acetyltransferase activity 3.80908511328212 bayes_pls_golite062009
acyltransferase activity 3.35206890637362 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.30532537006075 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.08442186629685 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
protein deacetylase activity 1.23680480131205 bayes_pls_golite062009
histone deacetylase activity 1.18932416576802 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.663171909351326 bayes_pls_golite062009
histone binding 0.557787598121402 bayes_pls_golite062009
deacetylase activity 0.530687254192222 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
cytoskeletal protein binding 0.236060274498333 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.141400887946529 bayes_pls_golite062009
telomeric DNA binding 0.0735027998484772 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [179-354] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FEREYDPTAE QLISNISLSS EDTEVDVMLK LAHVDIYTRR LRERARRKRM VRDYQLVSNF  60
   61 FRNRNYAQQQ GLTKEQREFR DRFRVYAQFY TCNEYERLLG SLEREKELRI RQSELYRYRY 120
  121 NGLTKIAECT HFEQHAATAT HRSTGPYGHG KTDHTHTSNG SHRPPSSSLH SPQPNL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [355-477] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKVEMSSGGE ASSNSIAPRN TLHIADPTCS GALLPSKNYL DSCRGSSAAT MLQTTGMVMG  60
   61 VTVDSGATTG VTSTATTMAN LPTNSAKGSQ QHLQPLQQHP QLLQSGNQHK MQNEAAGGGS 120
  121 DQV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [478-555] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSMSLKLRTQ LEELKHLPQP PGSELLSHNE LDLCKKHNIT PTTYLSVKTV CLSGAPSLGS  60
   61 PMETSLRKFF IKCGWLSH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 2aqeA
Description: Structural and functional analysis of ada2 alpha swirm domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
histone acetyltransferase activity 5.80609397811031 bayes_pls_golite062009
lysine N-acetyltransferase activity 5.80609397811031 bayes_pls_golite062009
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
N-acyltransferase activity 4.57418118498868 bayes_pls_golite062009
N-acetyltransferase activity 4.37954729923498 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
acetyltransferase activity 3.80908511328212 bayes_pls_golite062009
acyltransferase activity 3.35206890637362 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.30532537006075 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.08442186629685 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
protein deacetylase activity 1.23680480131205 bayes_pls_golite062009
histone deacetylase activity 1.18932416576802 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.663171909351326 bayes_pls_golite062009
histone binding 0.557787598121402 bayes_pls_golite062009
deacetylase activity 0.530687254192222 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
cytoskeletal protein binding 0.236060274498333 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.141400887946529 bayes_pls_golite062009
telomeric DNA binding 0.0735027998484772 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle