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View Structure Prediction Details

Protein: C85A2_ARATH
Organism: Arabidopsis thaliana
Length: 465 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C85A2_ARATH.

Description E-value Query
Range
Subject
Range
F3PH_ARATH - Flavonoid 3'-monooxygenase OS=Arabidopsis thaliana GN=CYP75B1 PE=1 SV=1
344.0 [0..1] [464..1]

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Predicted Domain #1
Region A:
Residues: [1-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIMMMILGL LVIIVCLCTA LLRWNQMRYS KKGLPPGTMG WPIFGETTEF LKQGPDFMKN  60
   61 QRLRYGSFFK SHILGCPTIV SMDAELNRYI LMNESKGLVA GYPQSMLDIL GTCNIAAVHG 120
  121 PSHRLMRGSL LSLISPTMMK DHLLPKIDDF MRNYLCGWDD LETVDIQEKT KHMAFLSSLL 180
  181 QIAETLKKPE VEEYRTEFFK LVVGTLSVPI DIPGTNYRSG VQARNNIDRL LTELMQERKE 240
  241 SGETFTDMLG YLMKKEDNRY LLTDKEIRDQ VVTILYSGYE TVSTTSMMAL KYLHDHPKAL 300
  301 EELRREHLAI RERKRPDEPL TLDDIKSMKF TRAVIFETSR LATIVNGVLR KTTHDLELNG 360
  361 YLIPKGWRIY VYTREINYDT SLYEDPMIFN PWRWMEKSLE SKSYFLLFGG GVRLCPGKEL 420
  421 GISEVSSFLH YFVTKYRWEE NGEDKLMVFP RVSAPKGYHL KCSPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.045757
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 5.03099580095037 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.55570471815523 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 2.29989218606587 bayes_pls_golite062009
oxidoreductase activity 2.09151585300316 bayes_pls_golite062009
oxygen binding 1.66120675703571 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.918503562996019 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 0.33710488712754 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.169431271735966 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 0.0888154993183798 bayes_pls_golite062009

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