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View Structure Prediction Details

Protein: gi|208966364
Organism: synthetic construct
Length: 308 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|208966364.

Description E-value Query
Range
Subject
Range
gi|1039318 - gi|1039318|emb|CAA82909.1| basic transcription factor 2, 35 kD subunit [Homo sapiens]
0.0 [1..302] [1..302]
gi|114647703 - gi|114647703|ref|XP_001170519.1| PREDICTED: general transcription factor IIH, polypeptide 3, 34kDa i...
0.0 [1..308] [1..308]
gi|57105536 - gi|57105536|ref|XP_534644.1| PREDICTED: similar to general transcription factor IIH, polypeptide 3, ...
0.0 [1..296] [1..296]
TF2H3_RAT - General transcription factor IIH subunit 3 OS=Rattus norvegicus GN=Gtf2h3 PE=2 SV=1
0.0 [1..297] [1..298]
TF2H3_MOUSE - General transcription factor IIH subunit 3 OS=Mus musculus GN=Gtf2h3 PE=1 SV=1
0.0 [1..297] [1..298]
TF2H3_BOVIN - General transcription factor IIH subunit 3 OS=Bos taurus GN=GTF2H3 PE=2 SV=1
0.0 [1..296] [1..297]

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Predicted Domain #1
Region A:
Residues: [1-221]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSDEDELNL LVIVVDANPI WWGKQALKES QFTLSKCIDA VMVLGNSHLF MNRSNKLAVI  60
   61 ASHIQESRFL YPGKNGRLGD FFGDPGNPPE FNPSGSKDGK YELLTSANEV IVEEIKDLMT 120
  121 KSDIKGQHTE TLLAGSLAKA LCYIHRMNKE VKDNQEMKSR ILVIKAAEDS ALQYMNFMNV 180
  181 IFAAQKQNIL IDACVLDSDS GLLQQACDIT GGLYLKVPQM P

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.99
Match: 1q0pA
Description: A domain of Factor B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.68315152218267 bayes_pls_golite062009
nucleic acid binding 2.10023916482665 bayes_pls_golite062009
DNA binding 1.9295508897092 bayes_pls_golite062009
protein complex binding 1.65763332955233 bayes_pls_golite062009
protein binding 1.42792331963866 bayes_pls_golite062009
hydrolase activity 0.589248272940562 bayes_pls_golite062009
structure-specific DNA binding 0.446181458443121 bayes_pls_golite062009
protein dimerization activity 0.244402438311177 bayes_pls_golite062009
protein heterodimerization activity 0.114607758890868 bayes_pls_golite062009
catalytic activity 0.0380261580236634 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [222-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLLQYLLWVF LPDQDQRSQL ILPPPVHVDY RAACFCHRNL IEIGYVCSVC LSIFCNFSPI  60
   61 CTTCETAFKI SLPPVLKAKK KKLKVSA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.965
Match: 1dvpA
Description: Hrs
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.84543733401722 bayes_pls_golite062009
binding 2.84147289283175 bayes_pls_golite062009
DNA binding 2.61461572393763 bayes_pls_golite062009
nucleic acid binding 2.59290953932215 bayes_pls_golite062009
endonuclease activity 2.2518780558155 bayes_pls_golite062009
transcription repressor activity 2.05685078783854 bayes_pls_golite062009
transcription factor activity 1.59046392323038 bayes_pls_golite062009
protein binding 1.32925779020231 bayes_pls_golite062009
histone binding 0.920809910112588 bayes_pls_golite062009
chromatin binding 0.887177003087523 bayes_pls_golite062009
transcription activator activity 0.663225694514289 bayes_pls_golite062009
protein deacetylase activity 0.645925926119566 bayes_pls_golite062009
histone deacetylase activity 0.637698619166566 bayes_pls_golite062009
hydrolase activity 0.594292092754636 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.585199046067846 bayes_pls_golite062009
histone acetyltransferase activity 0.585199046067846 bayes_pls_golite062009
sequence-specific DNA binding 0.0471610688739243 bayes_pls_golite062009
transcription factor binding 0.0293954104210474 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle