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View Structure Prediction Details

Protein: gi|207346252
Organism: Saccharomyces cerevisiae AWRI1631
Length: 321 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|207346252.

Description E-value Query
Range		 Subject
Range
gi|151942424 - gi|151942424|gb|EDN60780.1| transcription initiation factor TFIIH subunit [Saccharomyces cerevisiae ...
TFB3 - Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initia...
gi|190404617 - gi|190404617|gb|EDV07884.1| RNA polymerase II transcription factor B subunit 3 [Saccharomyces cerevi...
gi|207346252 - gi|207346252|gb|EDZ72804.1| YDR460Wp-like protein [Saccharomyces cerevisiae AWRI1631]
TFB3_YEAST - RNA polymerase II transcription factor B subunit 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
 2.0E-83 [1..321] [1..321]
gi|208966756 - gi|208966756|dbj|BAG73392.1| menage a trois homolog 1 [synthetic construct]
gi|109083843 - gi|109083843|ref|XP_001097131.1| PREDICTED: menage a trois 1 (CAK assembly factor) isoform 3 [Macaca...
gi|114653355 - gi|114653355|ref|XP_001167724.1| PREDICTED: menage a trois 1 (CAK assembly factor) isoform 3 [Pan tr...
MNAT1 - menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)
 7.0E-65 [9..313] [2..304]
MAT1_MOUSE - CDK-activating kinase assembly factor MAT1 OS=Mus musculus GN=Mnat1 PE=1 SV=2
 2.0E-61 [9..313] [2..304]
MAT1_XENLA - CDK-activating kinase assembly factor MAT1 OS=Xenopus laevis GN=mnat1 PE=2 SV=1
gi|2134192 - gi|2134192|pir||S60120 RING finger protein chain MAT1 - clawed frog
 1.0E-60 [9..313] [2..304]
MAT1_MARGL - CDK-activating kinase assembly factor MAT1 OS=Marthasterias glacialis PE=1 SV=1
 4.0E-57 [9..313] [3..305]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-56 [9..313] [2..262]
TFB3_SCHPO - RNA polymerase II transcription factor B subunit 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2...
pmh1 - transcription factor TFIIH complex subunit Pmh1
 2.0E-51 [10..313] [10..304]

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Predicted Domain #1
Region A:
Residues: [1-67] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLMDEYEENK DMCPICKTDR YLSPDVKFLV NPECYHRICE SCVDRIFSLG PAQCPYKGCD  60
   61 KILRKNK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 127.035458
Match: 1g25A_
Description: TFIIH Mat1 subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 6.51043144330453 bayes_pls_golite062009
ubiquitin-protein ligase activity 5.97121728620188 bayes_pls_golite062009
small conjugating protein ligase activity 5.78935175140238 bayes_pls_golite062009
acid-amino acid ligase activity 4.75377804653841 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.82459130917693 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
transcription repressor activity 1.98209395225978 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
ligase activity 0.63517530468004 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
transcription corepressor activity 0.384990496120483 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
transcription coactivator activity 0.255669498391574 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription activator activity 0.126093965701234 bayes_pls_golite062009
enzyme binding 0.104373352314595 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [68-264] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKTQIFDDVE VEKEVDIRKR VFNVFNKTID DFNGDLVEYN KYLEEVEDII YKLDHGIDVA  60
   61 KTEEKLRTYE ELNKQLIMNN LERSRTEIES FEQRQKFEKE MKLKKRLLER QIEEEERMNK 120
  121 EWTKKEIVNR LSTTTQDINE TIEGVKNTVK LKKSSARRKL EELNRVLKNN PYFNSNVNVQ 180
  181 NSRLKDAVPF TPFNGDR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [265-321] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAHPRFTLKG SVYNDPFIKD LEHRKEFIAS GFNTNYAYER VLTEAFMGLG CVISEEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.546 0.821 nucleotide-excision repair a.2.9 C-terminal UvrC-binding domain of UvrB

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle