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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sui2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • FAL1
  • nuclear outer membrane
  • nucleolus
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • ATP-dependent RNA helicase activity
  • GCD1
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • GCD2
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • GCD6
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • GCN3
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • SUI2
  • multi-eIF complex
  • cytoplasm
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • SUI3
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • TIF4632
  • eukaryotic translation initiation factor 4F complex
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 4F complex 7.5871E-12 12 4 4 6292
    eukaryotic translation initiation factor 2B complex 3.7897E-11 12 5 4 6292
    guanyl-nucleotide exchange factor complex 2.6474E-10 12 7 4 6292
    eukaryotic translation initiation factor 2 complex 5.3017E-9 12 3 3 6292
    protein complex 6.4659E-8 12 1137 11 6292
    ribosome 2.6703E-7 12 290 7 6292
    multi-eIF complex 2.953E-7 12 8 3 6292
    macromolecular complex 3.2574E-6 12 1635 11 6292
    ribonucleoprotein complex 1.2852E-5 12 514 7 6292
    non-membrane-bounded organelle 7.9037E-5 12 959 8 6292
    intracellular non-membrane-bounded organelle 7.9037E-5 12 959 8 6292
    cytoplasmic part 2.7242E-4 12 2482 11 6292
    plasma membrane enriched fraction 1.9072E-3 12 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translational initiation 3.365E-24 12 42 11 6292
    translation 3.4314E-13 12 376 11 6292
    regulation of translational initiation 4.4348E-12 12 11 5 6292
    gene expression 4.9591E-9 12 1283 12 6292
    cellular protein metabolic process 3.482E-8 12 1074 11 6292
    regulation of translation 3.8507E-8 12 57 5 6292
    posttranscriptional regulation of gene expression 5.4508E-8 12 61 5 6292
    protein metabolic process 6.4045E-8 12 1136 11 6292
    regulation of cellular protein metabolic process 9.4887E-8 12 68 5 6292
    cellular macromolecule biosynthetic process 1.0311E-7 12 1187 11 6292
    macromolecule biosynthetic process 1.0501E-7 12 1189 11 6292
    regulation of protein metabolic process 1.4581E-7 12 74 5 6292
    cellular biosynthetic process 2.065E-6 12 1567 11 6292
    biosynthetic process 2.6176E-6 12 1602 11 6292
    cellular macromolecule metabolic process 5.1661E-6 12 2285 12 6292
    macromolecule metabolic process 7.2022E-6 12 2349 12 6292
    primary metabolic process 8.9282E-5 12 2896 12 6292
    cellular metabolic process 1.5563E-4 12 3033 12 6292
    metabolic process 2.5194E-4 12 3157 12 6292
    regulation of gene expression 9.0312E-4 12 445 5 6292
    regulation of macromolecule biosynthetic process 1.0101E-3 12 456 5 6292
    regulation of cellular biosynthetic process 1.1824E-3 12 472 5 6292
    regulation of biosynthetic process 1.1939E-3 12 473 5 6292
    regulation of macromolecule metabolic process 1.3762E-3 12 488 5 6292
    regulation of primary metabolic process 1.7409E-3 12 514 5 6292
    regulation of cellular metabolic process 2.1025E-3 12 536 5 6292
    regulation of metabolic process 2.3031E-3 12 547 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation initiation factor activity 1.0272E-26 12 27 11 6292
    translation factor activity, nucleic acid binding 6.0273E-24 12 44 11 6292
    nucleic acid binding 1.8829E-10 12 666 11 6292
    binding 2.6244E-7 12 1294 11 6292
    guanyl-nucleotide exchange factor activity 5.4096E-7 12 38 4 6292
    GTPase regulator activity 1.349E-5 12 84 4 6292
    nucleoside-triphosphatase regulator activity 2.2008E-5 12 95 4 6292
    enzyme regulator activity 4.5761E-4 12 207 4 6292
    ATP-dependent RNA helicase activity 1.2263E-3 12 28 2 6292
    RNA-dependent ATPase activity 1.3157E-3 12 29 2 6292
    RNA helicase activity 2.752E-3 12 42 2 6292
    ATP-dependent helicase activity 3.5826E-3 12 48 2 6292
    purine NTP-dependent helicase activity 3.5826E-3 12 48 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle