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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Est1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 16 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CBF5
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
    		•
  • rRNA pseudouridine synthesis
  • ribosome biogenesis
    		•
  • pseudouridylate synthase activity
    		•
    DBP7
  • nuclear outer membrane
  • nucleolus
    		•
  • ribosome biogenesis
  • ribosomal large subunit assembly
    		•
  • ATP-dependent RNA helicase activity
    		•
    EST1
  • nucleus
  • telomerase holoenzyme complex
  • nucleolus
    		•
  • telomere maintenance
  • telomere maintenance via telomerase
    		•
  • telomerase activity
  • RNA binding
  • single-stranded DNA binding
    		•
    HSH49
  • U2 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    KRE33
  • nucleolus
    		•
  • ribosome biogenesis
    		•
  • molecular_function
    		•
    MRM1
  • mitochondrion
    		•
  • rRNA modification
    		•
  • rRNA (guanine-N1-)-methyltransferase activity
    		•
    MSS116
  • mitochondrial matrix
  • mitochondrion
    		•
  • RNA splicing
    		•
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
    		•
    PDI1
  • endoplasmic reticulum lumen
    		•
  • protein folding
    		•
  • protein disulfide isomerase activity
  • protein disulfide oxidoreductase activity
    		•
    PUF6
  • nucleus
  • nucleolus
    		•
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
    		•
  • mRNA binding
  • specific transcriptional repressor activity
    		•
    PWP1
  • nucleus
  • cytoplasm
  • nucleolus
    		•
  • rRNA processing
    		•
  • molecular_function
    		•
    RPF2
  • nucleolus
    		•
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
    		•
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
    		•
    RRP1
  • nucleus
  • nucleolus
    		•
  • ribosome biogenesis
  • rRNA processing
    		•
  • molecular_function
    		•
    RRP12
  • nucleus
  • ribosome
    		•
  • maturation of SSU-rRNA
  • ribosome biogenesis
    		•
  • molecular_function
    		•
    URB1
  • nucleolus
    		•
  • rRNA processing
  • processing of 27S pre-rRNA
    		•
  • molecular_function
    		•
    UTP10
  • mitochondrion
  • small nucleolar ribonucleoprotein complex
    		•
  • maturation of SSU-rRNA
  • ribosome biogenesis
    		•
  • snoRNA binding
    		•
    YER077C
  • mitochondrion
    		•
  • biological_process
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nucleolus 4.2269E-10 16 211 9 6292
    organelle lumen 4.1706E-8 16 660 11 6292
    intracellular organelle lumen 4.1706E-8 16 660 11 6292
    membrane-enclosed lumen 7.7514E-8 16 700 11 6292
    nuclear lumen 3.4877E-7 16 453 9 6292
    non-membrane-bounded organelle 2.1518E-5 16 959 10 6292
    intracellular non-membrane-bounded organelle 2.1518E-5 16 959 10 6292
    nuclear part 7.5837E-5 16 1103 10 6292
    membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular organelle 9.2974E-4 16 4070 16 6292
    organelle 9.334E-4 16 4071 16 6292
    intracellular organelle part 1.8408E-3 16 2282 12 6292
    organelle part 1.8408E-3 16 2282 12 6292
    nucleus 3.1363E-3 16 2041 11 6292
    box H/ACA snoRNP complex 5.0798E-3 16 2 1 6292
    ribonucleoprotein complex 7.2976E-3 16 514 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    ribosome biogenesis 4.0616E-11 16 346 11 6292
    ribonucleoprotein complex biogenesis 9.4707E-11 16 374 11 6292
    rRNA processing 1.2022E-8 16 128 7 6292
    rRNA metabolic process 1.9338E-8 16 137 7 6292
    cellular component biogenesis 7.0805E-8 16 694 11 6292
    RNA processing 7.6317E-8 16 380 9 6292
    ncRNA processing 4.3438E-7 16 215 7 6292
    ncRNA metabolic process 1.4584E-6 16 257 7 6292
    RNA metabolic process 2.052E-5 16 954 10 6292
    nucleic acid metabolic process 1.0065E-4 16 1415 11 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.6818E-4 16 1566 11 6292
    gene expression 2.8698E-4 16 1283 10 6292
    processing of 27S pre-rRNA 7.1262E-4 16 16 2 6292
    cellular nitrogen compound metabolic process 8.5298E-4 16 1770 11 6292
    rRNA modification 9.059E-4 16 18 2 6292
    nitrogen compound metabolic process 9.5191E-4 16 1791 11 6292
    cellular macromolecule metabolic process 1.8653E-3 16 2285 12 6292
    macromolecule metabolic process 2.4586E-3 16 2349 12 6292
    ribosomal large subunit assembly 4.6924E-3 16 41 2 6292
    ribosomal subunit assembly 8.3236E-3 16 55 2 6292
    maturation of SSU-rRNA 9.5338E-3 16 59 2 6292
    obsolete_biological_process 9.8479E-3 16 60 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA binding 1.8355E-4 16 367 6 6292
    ATP-dependent RNA helicase activity 2.2052E-3 16 28 2 6292
    RNA-dependent ATPase activity 2.365E-3 16 29 2 6292
    7S RNA binding 2.5429E-3 16 1 1 6292
    rRNA (guanine-N1-)-methyltransferase activity 2.5429E-3 16 1 1 6292
    nucleic acid binding 4.3373E-3 16 666 6 6292
    RNA helicase activity 4.9198E-3 16 42 2 6292
    5S rRNA binding 5.0798E-3 16 2 1 6292
    ATP-dependent helicase activity 6.3884E-3 16 48 2 6292
    purine NTP-dependent helicase activity 6.3884E-3 16 48 2 6292
    rRNA (guanine) methyltransferase activity 7.6106E-3 16 3 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle