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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sip2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARC35
  • cytosol
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • microtubule cytoskeleton organization
  • actin cytoskeleton organization
  • structural molecule activity
  • GAL83
  • nucleus
  • cytoplasm
  • nuclear envelope lumen
  • AMP-activated protein kinase complex
  • signal transduction
  • regulation of protein complex assembly
  • cell adhesion
  • invasive growth in response to glucose limitation
  • protein amino acid phosphorylation
  • AMP-activated protein kinase activity
  • IDH2
  • mitochondrial matrix
  • mitochondrion
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • SEC53
  • cytosol
  • protein targeting to ER
  • phosphomannomutase activity
  • SIP2
  • cytoplasm
  • plasma membrane
  • AMP-activated protein kinase complex
  • signal transduction
  • regulation of protein complex assembly
  • invasive growth in response to glucose limitation
  • protein amino acid phosphorylation
  • replicative cell aging
  • cellular response to glucose starvation
  • AMP-activated protein kinase activity
  • SNF1
  • nucleus
  • cytoplasm
  • mitochondrion
  • fungal-type vacuole
  • nuclear envelope lumen
  • AMP-activated protein kinase complex
  • regulation of carbohydrate metabolic process
  • signal transduction
  • pseudohyphal growth
  • cell adhesion
  • invasive growth in response to glucose limitation
  • protein amino acid phosphorylation
  • replicative cell aging
  • biofilm formation
  • positive regulation of gluconeogenesis
  • cellular response to nitrogen starvation
  • AMP-activated protein kinase activity
  • SNF4
  • nucleus
  • cytoplasm
  • nuclear envelope lumen
  • plasma membrane
  • AMP-activated protein kinase complex
  • peroxisome organization
  • protein amino acid phosphorylation
  • replicative cell aging
  • positive regulation of gluconeogenesis
  • regulation of transcription from RNA polymerase II promoter
  • AMP-activated protein kinase activity
  • protein serine/threonine kinase activator activity
  • TCP1
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    AMP-activated protein kinase complex 1.6077E-11 8 6 4 6292
    nuclear envelope lumen 5.3949E-9 8 4 3 6292
    organelle envelope lumen 1.3042E-5 8 40 3 6292
    protein complex 6.9038E-4 8 1137 6 6292
    nuclear envelope 1.5517E-3 8 199 3 6292
    cytosol 4.3023E-3 8 284 3 6292
    macromolecular complex 5.1894E-3 8 1635 6 6292
    membrane-enclosed lumen 7.3614E-3 8 700 4 6292
    Arp2/3 protein complex 8.8705E-3 8 7 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein amino acid phosphorylation 4.5093E-6 8 103 4 6292
    positive regulation of gluconeogenesis 8.4777E-6 8 4 2 6292
    replicative cell aging 1.1149E-5 8 38 3 6292
    invasive growth in response to glucose limitation 2.1315E-5 8 47 3 6292
    cell aging 2.4189E-5 8 49 3 6292
    aging 2.7309E-5 8 51 3 6292
    biological adhesion 3.9462E-5 8 8 2 6292
    positive regulation of glucose metabolic process 3.9462E-5 8 8 2 6292
    cell adhesion 3.9462E-5 8 8 2 6292
    positive regulation of cellular carbohydrate metabolic process 3.9462E-5 8 8 2 6292
    positive regulation of carbohydrate metabolic process 3.9462E-5 8 8 2 6292
    phosphorylation 4.0556E-5 8 179 4 6292
    regulation of protein complex assembly 7.7367E-5 8 11 2 6292
    phosphorus metabolic process 1.0663E-4 8 229 4 6292
    phosphate metabolic process 1.0663E-4 8 229 4 6292
    filamentous growth of a population of unicellular organisms 1.505E-4 8 90 3 6292
    growth of unicellular organism as a thread of attached cells 1.505E-4 8 90 3 6292
    regulation of gluconeogenesis 1.6826E-4 8 16 2 6292
    regulation of cellular component biogenesis 2.1426E-4 8 18 2 6292
    regulation of cellular ketone metabolic process 2.1426E-4 8 18 2 6292
    filamentous growth 2.4477E-4 8 106 3 6292
    regulation of carbohydrate biosynthetic process 3.2267E-4 8 22 2 6292
    cellular response to starvation 3.2267E-4 8 22 2 6292
    response to starvation 3.2267E-4 8 22 2 6292
    regulation of glucose metabolic process 5.646E-4 8 29 2 6292
    regulation of cellular carbohydrate metabolic process 5.646E-4 8 29 2 6292
    post-translational protein modification 5.9444E-4 8 357 4 6292
    growth 6.1672E-4 8 145 3 6292
    gluconeogenesis 7.3239E-4 8 33 2 6292
    cellular response to external stimulus 8.2428E-4 8 35 2 6292
    hexose biosynthetic process 8.2428E-4 8 35 2 6292
    cellular response to extracellular stimulus 8.2428E-4 8 35 2 6292
    cellular response to nutrient levels 8.2428E-4 8 35 2 6292
    regulation of carbohydrate metabolic process 8.7221E-4 8 36 2 6292
    monosaccharide biosynthetic process 9.7204E-4 8 38 2 6292
    response to extracellular stimulus 9.7204E-4 8 38 2 6292
    response to nutrient levels 9.7204E-4 8 38 2 6292
    response to external stimulus 9.7204E-4 8 38 2 6292
    pyruvate metabolic process 1.303E-3 8 44 2 6292
    alcohol biosynthetic process 1.4861E-3 8 47 2 6292
    cell communication 1.6147E-3 8 49 2 6292
    signal transduction 1.9142E-3 8 214 3 6292
    signal transmission 1.9926E-3 8 217 3 6292
    signaling process 1.9926E-3 8 217 3 6292
    protein modification process 2.1135E-3 8 499 4 6292
    cellular response to nitrogen levels 2.5415E-3 8 2 1 6292
    cellular response to nitrogen starvation 2.5415E-3 8 2 1 6292
    signaling 3.0608E-3 8 252 3 6292
    macromolecule modification 3.4456E-3 8 569 4 6292
    regulation of cellular component organization 3.7475E-3 8 75 2 6292
    cellular carbohydrate biosynthetic process 4.0477E-3 8 78 2 6292
    cellular protein metabolic process 5.103E-3 8 1074 5 6292
    carbohydrate biosynthetic process 5.474E-3 8 91 2 6292
    small molecule biosynthetic process 5.512E-3 8 310 3 6292
    cellular response to glucose starvation 6.3431E-3 8 5 1 6292
    isocitrate metabolic process 6.3431E-3 8 5 1 6292
    protein metabolic process 6.5695E-3 8 1136 5 6292
    developmental process 6.628E-3 8 331 3 6292
    carboxylic acid metabolic process 6.741E-3 8 333 3 6292
    organic acid metabolic process 6.741E-3 8 333 3 6292
    oxoacid metabolic process 6.741E-3 8 333 3 6292
    cellular ketone metabolic process 7.5041E-3 8 346 3 6292
    biofilm formation 7.6075E-3 8 6 1 6292
    glucose metabolic process 7.7782E-3 8 109 2 6292
    positive regulation of biosynthetic process 9.5206E-3 8 121 2 6292
    positive regulation of cellular biosynthetic process 9.5206E-3 8 121 2 6292
    hexose metabolic process 9.9814E-3 8 124 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    AMP-activated protein kinase activity 1.6077E-11 8 6 4 6292
    protein serine/threonine kinase activity 2.7428E-6 8 91 4 6292
    protein kinase activity 2.3558E-5 8 156 4 6292
    phosphotransferase activity, alcohol group as acceptor 6.0315E-5 8 198 4 6292
    kinase activity 9.4447E-5 8 222 4 6292
    transferase activity, transferring phosphorus-containing groups 1.1041E-3 8 420 4 6292
    phosphomannomutase activity 1.2715E-3 8 1 1 6292
    protein serine/threonine kinase activator activity 2.5415E-3 8 2 1 6292
    isocitrate dehydrogenase (NAD+) activity 2.5415E-3 8 2 1 6292
    isocitrate dehydrogenase activity 6.3431E-3 8 5 1 6292
    intramolecular transferase activity, phosphotransferases 8.8705E-3 8 7 1 6292

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