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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • LSM6
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP3
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SME1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SNU66
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U4/U6 x U5 tri-snRNP complex 2.8388E-29 12 32 12 6292
    small nuclear ribonucleoprotein complex 3.3549E-25 12 63 12 6292
    U5 snRNP 3.5036E-17 12 14 7 6292
    ribonucleoprotein complex 7.8427E-14 12 514 12 6292
    U1 snRNP 5.9069E-11 12 17 5 6292
    nuclear part 8.0153E-10 12 1103 12 6292
    macromolecular complex 9.1989E-8 12 1635 12 6292
    nucleus 1.3278E-6 12 2041 12 6292
    organelle part 5.0851E-6 12 2282 12 6292
    intracellular organelle part 5.0851E-6 12 2282 12 6292
    commitment complex 2.1777E-4 12 12 2 6292
    U2-type spliceosomal complex 2.1777E-4 12 12 2 6292
    membrane-bounded organelle 2.1329E-3 12 3771 12 6292
    intracellular membrane-bounded organelle 2.1329E-3 12 3771 12 6292
    spliceosomal complex 3.1543E-3 12 45 2 6292
    intracellular organelle 5.3355E-3 12 4070 12 6292
    organelle 5.3513E-3 12 4071 12 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 1.1622E-22 12 99 12 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.3207E-22 12 100 12 6292
    RNA splicing, via transesterification reactions 3.1165E-22 12 107 12 6292
    RNA splicing 4.3877E-21 12 132 12 6292
    mRNA processing 3.5331E-20 12 156 12 6292
    mRNA metabolic process 1.6695E-18 12 213 12 6292
    RNA processing 1.9966E-15 12 380 12 6292
    RNA metabolic process 1.3916E-10 12 954 12 6292
    gene expression 4.9591E-9 12 1283 12 6292
    nucleic acid metabolic process 1.6138E-8 12 1415 12 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.4733E-8 12 1566 12 6292
    cellular nitrogen compound metabolic process 2.3908E-7 12 1770 12 6292
    nitrogen compound metabolic process 2.7555E-7 12 1791 12 6292
    cellular macromolecule metabolic process 5.1661E-6 12 2285 12 6292
    macromolecule metabolic process 7.2022E-6 12 2349 12 6292
    primary metabolic process 8.9282E-5 12 2896 12 6292
    cellular metabolic process 1.5563E-4 12 3033 12 6292
    metabolic process 2.5194E-4 12 3157 12 6292
    regulation of hormone levels 1.9072E-3 12 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 1.9072E-3 12 1 1 6292
    auxin biosynthetic process 1.9072E-3 12 1 1 6292
    auxin metabolic process 1.9072E-3 12 1 1 6292
    hormone metabolic process 1.9072E-3 12 1 1 6292
    hormone biosynthetic process 1.9072E-3 12 1 1 6292
    nuclear mRNA 3'-splice site recognition 3.811E-3 12 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 5.0088E-8 12 367 8 6292
    nucleic acid binding 5.085E-6 12 666 8 6292
    binding 7.7038E-5 12 1294 9 6292
    mRNA binding 1.916E-3 12 35 2 6292
    U5 snRNA binding 3.811E-3 12 2 1 6292
    snRNA binding 9.5026E-3 12 5 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle