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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 22 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS11A, RPS11B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS1A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS3
  • preribosome, small subunit precursor
  • response to DNA damage stimulus
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 3.9045E-25 22 101 16 6292
    cytosolic part 9.8621E-24 22 122 16 6292
    ribosomal subunit 8.7181E-21 22 183 16 6292
    ribonucleoprotein complex 1.9181E-18 22 514 19 6292
    cytosol 1.1475E-17 22 284 16 6292
    ribosome 1.6089E-17 22 290 16 6292
    cytosolic large ribosomal subunit 1.5784E-13 22 60 9 6292
    cytosolic small ribosomal subunit 2.6126E-11 22 38 7 6292
    large ribosomal subunit 4.5126E-11 22 110 9 6292
    preribosome 1.0979E-9 22 34 6 6292
    90S preribosome 1.933E-9 22 17 5 6292
    non-membrane-bounded organelle 2.2809E-9 22 959 16 6292
    intracellular non-membrane-bounded organelle 2.2809E-9 22 959 16 6292
    small ribosomal subunit 3.1339E-9 22 73 7 6292
    macromolecular complex 4.6578E-9 22 1635 19 6292
    organelle part 5.4267E-4 22 2282 16 6292
    intracellular organelle part 5.4267E-4 22 2282 16 6292
    cytoplasmic part 1.5883E-3 22 2482 16 6292
    stress granule 3.4965E-3 22 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.4553E-25 22 376 21 6292
    cellular macromolecule biosynthetic process 9.8968E-17 22 1187 22 6292
    macromolecule biosynthetic process 1.0274E-16 22 1189 22 6292
    gene expression 5.5586E-16 22 1283 22 6292
    cellular protein metabolic process 1.1807E-15 22 1074 21 6292
    protein metabolic process 3.835E-15 22 1136 21 6292
    cellular biosynthetic process 4.6753E-14 22 1567 22 6292
    biosynthetic process 7.6257E-14 22 1602 22 6292
    cellular macromolecule metabolic process 1.9682E-10 22 2285 22 6292
    macromolecule metabolic process 3.6241E-10 22 2349 22 6292
    ribosomal subunit assembly 2.26E-8 22 55 6 6292
    regulation of translation 2.8166E-8 22 57 6 6292
    primary metabolic process 3.6936E-8 22 2896 22 6292
    posttranscriptional regulation of gene expression 4.2721E-8 22 61 6 6292
    ribosome assembly 5.7306E-8 22 64 6 6292
    regulation of cellular protein metabolic process 8.2928E-8 22 68 6 6292
    organelle assembly 9.0627E-8 22 69 6 6292
    cellular metabolic process 1.0248E-7 22 3033 22 6292
    regulation of protein metabolic process 1.3852E-7 22 74 6 6292
    metabolic process 2.482E-7 22 3157 22 6292
    ribonucleoprotein complex assembly 5.1249E-7 22 92 6 6292
    ribosomal small subunit biogenesis 1.5937E-6 22 26 4 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.0376E-5 22 13 3 6292
    ribosome biogenesis 1.2497E-5 22 346 8 6292
    ribosomal small subunit assembly 1.3176E-5 22 14 3 6292
    ribonucleoprotein complex biogenesis 2.2116E-5 22 374 8 6292
    cellular macromolecular complex assembly 2.7358E-5 22 182 6 6292
    maturation of SSU-rRNA 4.4978E-5 22 59 4 6292
    cellular macromolecular complex subunit organization 1.9625E-4 22 259 6 6292
    macromolecular complex assembly 3.0611E-4 22 281 6 6292
    ribosomal large subunit assembly 3.6295E-4 22 41 3 6292
    cellular process 4.2871E-4 22 4426 22 6292
    regulation of gene expression 5.6575E-4 22 445 7 6292
    regulation of macromolecule biosynthetic process 6.5598E-4 22 456 7 6292
    regulation of cellular biosynthetic process 8.0755E-4 22 472 7 6292
    regulation of biosynthetic process 8.1788E-4 22 473 7 6292
    rRNA processing 8.9959E-4 22 128 4 6292
    regulation of macromolecule metabolic process 9.8602E-4 22 488 7 6292
    macromolecular complex subunit organization 1.0977E-3 22 357 6 6292
    rRNA metabolic process 1.16E-3 22 137 4 6292
    regulation of primary metabolic process 1.3421E-3 22 514 7 6292
    ribosomal large subunit biogenesis 1.4085E-3 22 65 3 6292
    cellular component assembly 1.6262E-3 22 385 6 6292
    cellular component biogenesis 1.6393E-3 22 694 8 6292
    regulation of cellular metabolic process 1.7173E-3 22 536 7 6292
    regulation of metabolic process 1.9337E-3 22 547 7 6292
    response to cycloalkane 3.4965E-3 22 1 1 6292
    response to organic cyclic substance 3.4965E-3 22 1 1 6292
    response to cycloheximide 3.4965E-3 22 1 1 6292
    ncRNA processing 5.9739E-3 22 215 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 9.5024E-31 22 212 21 6292
    structural molecule activity 2.6326E-26 22 339 21 6292
    RNA binding 1.7228E-4 22 367 7 6292
    rRNA binding 1.3596E-3 22 16 2 6292
    nucleic acid binding 5.9264E-3 22 666 7 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle