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Protein Overview: CHS3

General Information:
Name(s) found: CHS3 / YBR023C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1165 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed articleLink to PubMed article]
    prospore membrane [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed articleLink to PubMed article]
    chitosome [IDALink to PubMed article]
    Biological Process: cytokinesis [TASLink to PubMed article]
    ascospore wall assembly [IMPLink to PubMed article]
    cell wall chitin biosynthetic process [TASLink to PubMed article]
    Molecular Function: chitin synthase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGLNGDDPD DYYLNLNQDE ESLLRSRHSV GSGAPHRQGS LVRPERSRLN NPDNPHFYYA  60
   61 QKTQEQMNHL DVLPSSTGVN PNATRRSGSL RSKGSVRSKF SGRETDSYLL QDMNTTDKKA 120
  121 SVKISDEGVA EDEFDKDGDV DNFEESSTQP INKSIKPLRK ETNDTLSFWQ MYCYFITFWA 180
  181 PAPILAFCGM PKKERQMAWR EKVALISVIL YIGAIVAFLT FGFTKTVCSS SKLRLKNNEV 240
  241 STEFVVINGK AYELDTSSRS GIQDVEVDSD TLYGPWSDAG KDASFLFQNV NGNCHNLITP 300
  301 KSNSSIPHDD DNNLAWYFPC KLKNQDGSSK PNFTVENYAG WNCHTSKEDR DAFYGLKSKA 360
  361 DVYFTWDGIK NSSRNLIVYN GDVLDLDLLD WLEKDDVDYP VVFDDLKTSN LQGYDLSLVL 420
  421 SNGHERKIAR CLSEIIKVGE VDSKTVGCIA SDVVLYVSLV FILSVVIIKF IIACYFRWTV 480
  481 ARKQGAYIVD NKTMDKHTND IEDWSNNIQT KAPLKEVDPH LRPKKYSKKS LGHKRASTFD 540
  541 LLKKHSSKMF QFNESVIDLD TSMSSSLQSS GSYRGMTTMT TQNAWKLSNE NKAVHSRNPS 600
  601 TLLPTSSMFW NKATSSPVPG SSLIQSLDST IIHPDIVQQP PLDFMPYGFP LIHTICFVTC 660
  661 YSEDEEGLRT TLDSLSTTDY PNSHKLLMVV CDGLIKGSGN DKTTPEIALG MMDDFVTPPD 720
  721 EVKPYSYVAV ASGSKRHNMA KIYAGFYKYD DSTIPPENQQ RVPIITIVKC GTPAEQGAAK 780
  781 PGNRGKRDSQ IILMSFLEKI TFDERMTQLE FQLLKNIWQI TGLMADFYET VLMVDADTKV 840
  841 FPDALTHMVA EMVKDPLIMG LCGETKIANK AQSWVTAIQV FEYYISHHQA KAFESVFGSV 900
  901 TCLPGCFSMY RIKSPKGSDG YWVPVLANPD IVERYSDNVT NTLHKKNLLL LGEDRFLSSL 960
  961 MLKTFPKRKQ VFVPKAACKT IAPDKFKVLL SQRRRWINST VHNLFELVLI RDLCGTFCFS1020
 1021 MQFVIGIELI GTMVLPLAIC FTIYVIIFAI VSKPTPVITL VLLAIILGLP GLIVVITATR1080
 1081 WSYLWWMCVY ICALPIWNFV LPSYAYWKFD DFSWGDTRTI AGGNKKAQDE NEGEFDHSKI1140
 1141 KMRTWREFER EDILNRKEES DSFVA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CHS3 LYS14 MSL1 NMD2 SUR7 UPF3
    View Details Qiu et al. (2008) CHS1 CHS3 GSC2 SPS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GPI14 CHS3 2 Hazbun TR, et al. (2003)
    View Screen ILM1 CHS3 2 Lockshon D, et al. (2006)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CHS3 Huh WK, et al. (2003)
    View Data CHS3 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] deduced N/A No confident structure predictions are available.
    2 View Details [73..543] MSA 1.055874 View MSA. No confident structure predictions are available.
    3 View Details [544..627] deduced N/A No confident structure predictions are available.
    4 View Details [628..1165] Pfam 1000.0 Chitin synthase No confident structure predictions are available.
    5 View Details [642..739] Pfam 5.075721 No description for PF03142.6 was found. No confident structure predictions are available.
    6 View Details [740..984] FFAS03 2.0 Spore coat polysaccharide biosynthesis protein SpsA
    7 View Details [985..1165] Pfam 14.744727 No description for PF03142.6 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • transferase activity, transferring hexosyl groups
    		•  2.23446625487311 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  1.84596125277114 bayes_pls_golite062009
  • catalytic activity
    		•  1.73979371332125 bayes_pls_golite062009
  • transferase activity
    		•  1.18156663897445 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  0.823843077041128 bayes_pls_golite062009
  • cytidylyltransferase activity
    		•  0.666765511953956 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.641710647713692 bayes_pls_golite062009
  • binding
    		•  0.61043334112269 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  0.600389101620522 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.539883035270389 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  0.505948108814334 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.301396160525425 bayes_pls_golite062009
  • UDP-N-acetylglucosamine diphosphorylase activity
    		•  0.0309517682490415 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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