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Protein Overview: LYS14

General Information:
Name(s) found: LYS14 / YDR034C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 790 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: lysine biosynthetic process via aminoadipic acid [TASLink to PubMed article]
    Molecular Function: transcription activator activity [IMPLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFESVNLDEN SPEDRELAKV LSPPGSYLSP ASLDSGSSFT NSGTSTSCFE PKNNLPSLSF  60
   61 LNARAGSLGG IFNHKQMTSP SNSNIGGENV ESTTSSNDGS NENAGHPTTS EQDQNADHPT 120
  121 ISQADDNGHS SLTPNPAVTS TVTDKKGNTV KRKYSRNGCS ECKRRRMKCD ETKPTCWQCA 180
  181 RLNRQCVYVL NPKNKKRRTS NAQRVKEFRK HSTSLDNDHN NARKRQHSSC KAEKKKKVRQ 240
  241 NLSEDTTDPK PITDNGKNVP LDEIESLEIP NLDLTTTMNG YDVNLLMQNL NDMVNMKLHD 300
  301 SYLLNEELKG LDLPDLDIPE LLPASNVNSS VPISFLVNNV ITFNTKLSSF KLGGIHDKYL 360
  361 KIFYYDCLDS IAPFFQNQGN PLRDILLSFA KNEAYLLSSI LATGASIAYR KSNNLEDERN 420
  421 YCAYLSHCLS LLGEQFKNES NVLNRIEPII LTVIMLAWDC IYSMNSQWRS HLKGVTDLFK 480
  481 KINAGNSSKV LNVAKCWFKV METFASISTV FGGSLIDNND LDAIFDPYDY QYVDSLKFLN 540
  541 IMTPLNEFNL LRGHKEDFDL VIKEVFKSLN TIRSTEKNYF SKEEGLFTKK LDYLLLSSQT 600
  601 SSEKSKDQIS YFNTQKILVE IDKQLDYEFI DKSGIIPSDN QSHPRISNIH DNAIDMVTLK 660
  661 NGEEVAISWY DISHQTQVLS FLLIVLLKLL GMPKESSTIQ QVVKKIMSFF KFLDSDSPPQ 720
  721 NSRTCYSNFA VLIAGLNAMD EETRAIVKRY YKINGGKFQK LTEHNLNRLE KVWYGKNQNY 780
  781 RLEEQDVLTW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CHS3 LYS14 MSL1 NMD2 SUR7 UPF3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LYS14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152] MSA 21.277997 View MSA. No confident structure predictions are available.
    2 View Details [153..233] Pfam 5.619789 Fungal Zn(2)-Cys(6) binuclear cluster domain No confident structure predictions are available.
    3 View Details [234..790] deduced N/A No confident structure predictions are available.
    4 View Details [355..553] deduced N/A No confident structure predictions are available.
    5 View Details [554..639] deduced N/A No confident structure predictions are available.
    6 View Details [640..790] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.03201524223606 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.87955444697212 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.86200506906385 bayes_pls_golite062009
  • transcription activator activity
    		•  0.915626626047549 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle