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Protein Overview: ARG1

General Information:
Name(s) found: ARG1 / YOL058W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 420 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: argininosuccinate metabolic process [TASLink to PubMed article]
    arginine biosynthetic process [TASLink to PubMed article]
    citrulline metabolic process [NASLink to PubMed article]
    Molecular Function: argininosuccinate synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKGKVCLAY SGGLDTSVIL AWLLDQGYEV VAFMANVGQE EDFDAAKEKA LKIGACKFVC  60
   61 VDCREDFVKD ILFPAVQVNA VYEDVYLLGT SLARPVIAKA QIDVAKQEGC FAVSHGCTGK 120
  121 GNDQIRFELS FYALKPDVKC ITPWRMPEFF ERFAGRKDLL DYAAQKGIPV AQTKAKPWST 180
  181 DENQAHISYE AGILEDPDTT PPKDMWKLIV DPMDAPDQPQ DLTIDFERGL PVKLTYTDNK 240
  241 TSKEVSVTKP LDVFLAASNL ARANGVGRID IVEDRYINLK SRGCYEQAPL TVLRKAHVDL 300
  301 EGLTLDKEVR QLRDSFVTPN YSRLIYNGFL LHPECEYIRS MIQPSQNSVN GTVRVRLYKG 360
  361 NVIILGRSTK TEKLYDPTES SMDELTGFLP TDTTGFIAIQ AIRIKKYGES KKTKGEELTL 420
  421

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ARG1 CDC33 COR1 KGD2 KRS1 LPD1 PMI40 RVB2 RVS161 RVS167 SES1 TRP5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ARG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63]
    [95..177]    		 PSI-BLAST 1081.9897 Argininosuccinate synthetase, N-terminal domain; Argininosuccinate synthetase, C-terminal domain
    2 View Details [64..94]
    [178..208]
    [268..287]
    [310..345]    		 PSI-BLAST 1081.9897 Argininosuccinate synthetase, N-terminal domain; Argininosuccinate synthetase, C-terminal domain
    3 View Details [209..267]
    [288..309]
    [346..420]    		 PSI-BLAST 1081.9897 Argininosuccinate synthetase, N-terminal domain; Argininosuccinate synthetase, C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.60

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle