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Protein Overview: YDR049W

General Information:
Name(s) found: YDR049W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Zinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 632 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [NCBI BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSQKASKMT GSLKKNDLYI FDLSEQLLNS LKLMSFDSTL REVEVEKTSD NDRNKESGDL  60
   61 QIARKKVTSN VMRCSVCQMS FDSRNEQKAH YQTDYHLMNV KRNLRGLDIL SVEEFDALIS 120
  121 KEHGIKSEDE NSGGEQTSSD HEESEEASDR DPDLQTNNYM ETIIENDLQK LGFQKDESDA 180
  181 ISHINTQSPY IYFKSKYLQK NEVLAIYKSL FNKRSLSNPN EALTFWNSQE NPMAISALFM 240
  241 VGGGHFAGAI VSHQRLNVKG NAHKKDETLI EQAVNFLEHK TFHRYTTRRK QGGSQSAMDN 300
  301 AKGKANSAGS ALRRYNESAL KTDIQGVLKD WEPYLSKCDN IFIRARNVSD KKIFTDNTVL 360
  361 NKGDERIKSF PFTTNRPTVL ELKKAWCELS YLKILPKPEP LAVKETVQKL EVSNKKDEFK 420
  421 EKQEPLLEEI QTEEIISLLK KGRAPLLISF LKKNKLDGNF RLKPESKYSL TPTMLHYASQ 480
  481 QGMKQMALIL LSNIKCDPTI KNRLGRTAWD LNRNDDVRHA FQIARYNLGE SFTNWDETHI 540
  541 GQPLSREQVD EINEKKKAIE NEKAEKLIKL ELEAAKEKQR FAKDAERGPG KKLTNIPSIQ 600
  601 QQNLNSLTDE QRRRLMREQR ARAAEERMKK KY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) Manuscript in preparation. CDC48 NPL4 YDR049W
    View Details Krogan NJ, et al. (2006) BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C
    View Details Gavin AC, et al. (2006) CDC48 NPL4 SHP1 UFD1 YDR049W
    View Details Gavin AC, et al. (2002) BNI1 CDC48 DOA1 MRPS28 NPL4 PDC1 RAI1 REG1 RPA135 RPA190 RPO31 SHP1 UFD1 YDR049W
    View Details Ho Y, et al. (2002) DSK2 HMF1 NPL4 RAD23 SHP1 TSL1 UBI4 UFD2 YDR049W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YDR049W HRP1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YDR049W Huh WK, et al. (2003)
    [View in YRC Public Image Repository] (1 experiment(s)and 3 images)

    Protein Structure Data


    [What does the above image mean?] [View Top Sequence Alignments]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] MSA 11.021989 View MSA. No confident structure predictions are available.
    2 View Details [188..305] deduced N/A No confident structure predictions are available.
    3 View Details [306..462] PSI-BLAST 20.522879 I-kappa-B-alpha
    4 View Details [463..542] PSI-BLAST 20.522879 I-kappa-B-alpha
    5 View Details [543..632] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  2.85972242708612 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.77701617604772 bayes_pls_golite062009
  • DNA binding
    		•  2.71411659179983 bayes_pls_golite062009
  • binding
    		•  1.97525193898847 bayes_pls_golite062009
  • transcription factor activity
    		•  1.90143001800384 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.06438483834477 bayes_pls_golite062009
  • transcription activator activity
    		•  0.888241744617002 bayes_pls_golite062009
  • protein binding
    		•  0.721263040163177 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.375362589875489 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.226250920465406 bayes_pls_golite062009
  • transcription factor binding
    		•  0.191965432731838 bayes_pls_golite062009
  • chromatin binding
    		•  0.131327938577204 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  1.58699086730647 bayes_pls_golite062009
  • protein binding
    		•  1.41750957807465 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.668531056539717 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.403559033288365 bayes_pls_golite062009
  • DNA binding
    		•  0.186657583240225 bayes_pls_golite062009
  • ligase activity
    		•  0.0845684108313678 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0182460237384001 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by:     Michael Riffle