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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rvs167. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARG1
  • cytosol
  • argininosuccinate metabolic process
  • arginine biosynthetic process
  • citrulline metabolic process
  • argininosuccinate synthase activity
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • COR1
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • KGD2
  • mitochondrial matrix
  • mitochondrial oxoglutarate dehydrogenase complex
  • mitochondrion
  • mitochondrial nucleoid
  • tricarboxylic acid cycle
  • 2-oxoglutarate metabolic process
  • dihydrolipoyllysine-residue succinyltransferase activity
  • KRS1
  • cytoplasm
  • lysyl-tRNA aminoacylation
  • lysine-tRNA ligase activity
  • LPD1
  • mitochondrial pyruvate dehydrogenase complex
  • mitochondrial oxoglutarate dehydrogenase complex
  • mitochondrion
  • glycine cleavage complex
  • mitochondrial nucleoid
  • acetyl-CoA biosynthetic process from pyruvate
  • leucine catabolic process
  • valine catabolic process
  • L-serine biosynthetic process
  • isoleucine catabolic process
  • glycine catabolic process
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
  • pyruvate dehydrogenase (acetyl-transferring) activity
  • glycine dehydrogenase (decarboxylating) activity
  • dihydrolipoyl dehydrogenase activity
  • PMI40
  • nucleus
  • cytoplasm
  • cell wall mannoprotein biosynthetic process
  • GDP-mannose biosynthetic process
  • protein amino acid glycosylation
  • mannose-6-phosphate isomerase activity
  • RVB2
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • nuclear outer membrane
  • chromatin remodeling complex
  • chromatin remodeling
  • snoRNA metabolic process
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • RVS161
  • mating projection
  • membrane raft
  • actin cortical patch
  • bipolar cellular bud site selection
  • response to osmotic stress
  • endocytosis
  • cytoskeletal protein binding
  • RVS167
  • actin cortical patch
  • vesicle-mediated transport
  • bipolar cellular bud site selection
  • response to osmotic stress
  • endocytosis
  • cytoskeletal protein binding
  • SES1
  • cytoplasm
  • seryl-tRNA aminoacylation
  • serine-tRNA ligase activity
  • TRP5
  • nucleus
  • cytoplasm
  • tryptophan biosynthetic process
  • tryptophan synthase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrial oxoglutarate dehydrogenase complex 9.9937E-6 12 3 2 6292
    oxoglutarate dehydrogenase complex 9.9937E-6 12 3 2 6292
    nucleoid 1.0566E-3 12 26 2 6292
    mitochondrial nucleoid 1.0566E-3 12 26 2 6292
    actin cortical patch 2.6238E-3 12 41 2 6292
    cortical actin cytoskeleton 4.1936E-3 12 52 2 6292
    cortical cytoskeleton 4.1936E-3 12 52 2 6292
    non-membrane-bounded organelle 4.9929E-3 12 959 6 6292
    intracellular non-membrane-bounded organelle 4.9929E-3 12 959 6 6292
    eukaryotic translation initiation factor 4F complex 7.6087E-3 12 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    organic acid metabolic process 1.4804E-5 12 333 6 6292
    oxoacid metabolic process 1.4804E-5 12 333 6 6292
    carboxylic acid metabolic process 1.4804E-5 12 333 6 6292
    cellular ketone metabolic process 1.8454E-5 12 346 6 6292
    cellular amino acid metabolic process 1.9893E-5 12 199 5 6292
    cellular amine metabolic process 3.3807E-5 12 222 5 6292
    amine metabolic process 5.2277E-5 12 243 5 6292
    cellular amino acid and derivative metabolic process 5.2277E-5 12 243 5 6292
    small molecule metabolic process 1.67E-4 12 760 7 6292
    acetyl-CoA metabolic process 6.2163E-4 12 20 2 6292
    cellular amino acid biosynthetic process 1.1312E-3 12 114 3 6292
    amine biosynthetic process 1.3769E-3 12 122 3 6292
    dicarboxylic acid metabolic process 1.4082E-3 12 30 2 6292
    tRNA aminoacylation for protein translation 1.7038E-3 12 33 2 6292
    tRNA aminoacylation 1.7038E-3 12 33 2 6292
    amino acid activation 1.7038E-3 12 33 2 6292
    bipolar cellular bud site selection 1.8084E-3 12 34 2 6292
    argininosuccinate metabolic process 1.9072E-3 12 1 1 6292
    citrulline metabolic process 1.9072E-3 12 1 1 6292
    valine catabolic process 1.9072E-3 12 1 1 6292
    valine metabolic process 1.9072E-3 12 1 1 6292
    isoleucine catabolic process 1.9072E-3 12 1 1 6292
    carboxylic acid biosynthetic process 2.0055E-3 12 139 3 6292
    organic acid biosynthetic process 2.0055E-3 12 139 3 6292
    small molecule biosynthetic process 2.0878E-3 12 310 4 6292
    cellular biosynthetic process 2.6841E-3 12 1567 8 6292
    biosynthetic process 3.1247E-3 12 1602 8 6292
    acetyl-CoA biosynthetic process from pyruvate 3.811E-3 12 2 1 6292
    nucleotide-sugar biosynthetic process 3.811E-3 12 2 1 6292
    L-serine metabolic process 3.811E-3 12 2 1 6292
    L-serine biosynthetic process 3.811E-3 12 2 1 6292
    leucine catabolic process 3.811E-3 12 2 1 6292
    lysyl-tRNA aminoacylation 3.811E-3 12 2 1 6292
    seryl-tRNA aminoacylation 3.811E-3 12 2 1 6292
    mannose biosynthetic process 3.811E-3 12 2 1 6292
    GDP-mannose metabolic process 3.811E-3 12 2 1 6292
    GDP-mannose biosynthetic process 3.811E-3 12 2 1 6292
    2-oxoglutarate metabolic process 3.811E-3 12 2 1 6292
    isoleucine metabolic process 5.7116E-3 12 3 1 6292
    cellular amino acid derivative metabolic process 5.7327E-3 12 61 2 6292
    cellular nitrogen compound metabolic process 6.1479E-3 12 1770 8 6292
    nitrogen compound metabolic process 6.653E-3 12 1791 8 6292
    acetyl-CoA biosynthetic process 7.6087E-3 12 4 1 6292
    branched chain family amino acid catabolic process 7.6087E-3 12 4 1 6292
    cellular bud site selection 8.3454E-3 12 74 2 6292
    cytokinesis, site selection 8.3454E-3 12 74 2 6292
    response to osmotic stress 9.0119E-3 12 77 2 6292
    cell cycle cytokinesis 9.7018E-3 12 80 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    dihydrolipoyl dehydrogenase activity 1.9072E-3 12 1 1 6292
    mannose-6-phosphate isomerase activity 1.9072E-3 12 1 1 6292
    dihydrolipoyllysine-residue succinyltransferase activity 1.9072E-3 12 1 1 6292
    tryptophan synthase activity 1.9072E-3 12 1 1 6292
    S-succinyltransferase activity 1.9072E-3 12 1 1 6292
    argininosuccinate synthase activity 1.9072E-3 12 1 1 6292
    aminoacyl-tRNA ligase activity 2.2566E-3 12 38 2 6292
    ligase activity, forming aminoacyl-tRNA and related compounds 2.2566E-3 12 38 2 6292
    ligase activity, forming carbon-oxygen bonds 2.2566E-3 12 38 2 6292
    ligase activity 2.4944E-3 12 150 3 6292
    oxoglutarate dehydrogenase (succinyl-transferring) activity 3.811E-3 12 2 1 6292
    lysine-tRNA ligase activity 3.811E-3 12 2 1 6292
    serine-tRNA ligase activity 3.811E-3 12 2 1 6292
    succinyltransferase activity 3.811E-3 12 2 1 6292
    catalytic activity 4.6325E-3 12 2150 9 6292
    cytoskeletal protein binding 5.3712E-3 12 59 2 6292
    pyruvate dehydrogenase (acetyl-transferring) activity 7.6087E-3 12 4 1 6292
    pyruvate dehydrogenase activity 7.6087E-3 12 4 1 6292
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 9.5026E-3 12 5 1 6292

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