YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes:	This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rrp13. The topolgies of protein complexes in this experiment are unknown.
Complex Size:	16 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
CKA2	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 activity
CKB2	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 regulator activity
DBP10	nuclear outer membrane nucleolus	ribosome biogenesis ribosomal large subunit assembly	ATP-dependent RNA helicase activity
HAS1	nuclear envelope nucleolus	ribosome biogenesis rRNA processing	RNA binding RNA-dependent ATPase activity ATP-dependent RNA helicase activity
MAM33	mitochondrial matrix mitochondrion	response to drug aerobic respiration	molecular_function
NOP1	nuclear outer membrane nucleolus ribosome small nucleolar ribonucleoprotein complex	rRNA modification RNA methylation maturation of SSU-rRNA ribosome biogenesis ribosomal large subunit assembly snoRNA 3'-end processing	methyltransferase activity
NOP7	nucleus nucleolus	cell proliferation maturation of SSU-rRNA ribosomal large subunit biogenesis ribosome biogenesis cell cycle	molecular_function
NUG1	nucleus nucleolus	ribosome biogenesis rRNA processing	GTPase activity
RPF2	nucleolus	ribosome biogenesis ribosomal large subunit assembly processing of 27S pre-rRNA	5S rRNA binding 7S RNA binding rRNA binding
RRP1	nucleus nucleolus	ribosome biogenesis rRNA processing	molecular_function
RRP15	nucleus nucleolus	ribosome biogenesis processing of 27S pre-rRNA	molecular_function
RRP5	nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis rRNA processing	RNA binding snoRNA binding rRNA primary transcript binding
SPB1	nucleus nucleolus	rRNA methylation processing of 27S pre-rRNA	rRNA (uridine-2'-O-)-methyltransferase activity rRNA (guanine) methyltransferase activity
SRP1	nucleus cytoplasm	nucleocytoplasmic transport	protein transmembrane transporter activity
TIF6	nucleus cytoplasm nuclear outer membrane nucleolus	ribosomal subunit export from nucleus ribosomal large subunit biogenesis processing of 27S pre-rRNA	ribosomal large subunit binding
YTM1	nucleus nucleolus	ribosomal large subunit biogenesis ribosome biogenesis	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nucleolus	2.4022E-15	16	211	12	6292
nuclear lumen	2.3559E-11	16	453	12	6292
organelle lumen	6.9304E-11	16	660	13	6292
intracellular organelle lumen	6.9304E-11	16	660	13	6292
membrane-enclosed lumen	1.4702E-10	16	700	13	6292
non-membrane-bounded organelle	1.4823E-7	16	959	12	6292
intracellular non-membrane-bounded organelle	1.4823E-7	16	959	12	6292
nuclear part	7.2588E-7	16	1103	12	6292
protein kinase CK2 complex	3.6271E-5	16	4	2	6292
nuclear outer membrane	5.2245E-5	16	86	4	6292
nucleus	8.2656E-5	16	2041	13	6292
nuclear membrane	8.3815E-5	16	97	4	6292
nuclear envelope	9.8913E-5	16	199	5	6292
organelle part	3.0309E-4	16	2282	13	6292
intracellular organelle part	3.0309E-4	16	2282	13	6292
outer membrane	8.6327E-4	16	178	4	6292
organelle outer membrane	8.6327E-4	16	178	4	6292
nuclear membrane-endoplasmic reticulum network	2.3097E-3	16	232	4	6292
endomembrane system	2.4092E-3	16	398	5	6292
envelope	6.7707E-3	16	505	5	6292
organelle envelope	6.7707E-3	16	505	5	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
ribosome biogenesis	9.4815E-13	16	346	12	6292
ribonucleoprotein complex biogenesis	2.4056E-12	16	374	12	6292
cellular component biogenesis	3.553E-9	16	694	12	6292
ribosomal large subunit biogenesis	7.0967E-9	16	65	6	6292
rRNA processing	1.2022E-8	16	128	7	6292
rRNA metabolic process	1.9338E-8	16	137	7	6292
processing of 27S pre-rRNA	4.9848E-8	16	16	4	6292
ncRNA processing	4.3438E-7	16	215	7	6292
ncRNA metabolic process	1.4584E-6	16	257	7	6292
obsolete_biological_process	1.2486E-5	16	60	4	6292
RNA processing	1.972E-5	16	380	7	6292
regulation of transcription from RNA polymerase I promoter	3.6271E-5	16	4	2	6292
regulation of transcription from RNA polymerase III promoter	1.2639E-4	16	7	2	6292
ribosomal large subunit assembly	1.3562E-4	16	41	3	6292
RNA metabolic process	1.7033E-4	16	954	9	6292
flocculation via cell wall protein-carbohydrate interaction	2.6962E-4	16	10	2	6292
ribosomal subunit assembly	3.2659E-4	16	55	3	6292
flocculation	3.2905E-4	16	11	2	6292
maturation of SSU-rRNA	4.0219E-4	16	59	3	6292
ribosome assembly	5.1146E-4	16	64	3	6292
organelle assembly	6.382E-4	16	69	3	6292
rRNA modification	9.059E-4	16	18	2	6292
RNA methylation	1.011E-3	16	19	2	6292
ribonucleoprotein complex assembly	1.476E-3	16	92	3	6292
gene expression	1.6813E-3	16	1283	9	6292
G2/M transition of mitotic cell cycle	2.365E-3	16	29	2	6292
transcription from RNA polymerase I promoter	2.5302E-3	16	30	2	6292
nucleic acid metabolic process	3.4654E-3	16	1415	9	6292
cellular process	3.565E-3	16	4426	16	6292
transcription from RNA polymerase III promoter	4.0408E-3	16	38	2	6292
macromolecule methylation	5.1521E-3	16	43	2	6292
methylation	5.1521E-3	16	43	2	6292
G1/S transition of mitotic cell cycle	6.9173E-3	16	50	2	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	7.1701E-3	16	1566	9	6292
rRNA methylation	7.6106E-3	16	3	1	6292
one-carbon metabolic process	8.3236E-3	16	55	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
rRNA binding	7.1262E-4	16	16	2	6292
ATP-dependent RNA helicase activity	2.2052E-3	16	28	2	6292
RNA-dependent ATPase activity	2.365E-3	16	29	2	6292
ribosomal large subunit binding	2.5429E-3	16	1	1	6292
7S RNA binding	2.5429E-3	16	1	1	6292
RNA helicase activity	4.9198E-3	16	42	2	6292
protein kinase CK2 activity	5.0798E-3	16	2	1	6292
5S rRNA binding	5.0798E-3	16	2	1	6292
protein kinase CK2 regulator activity	5.0798E-3	16	2	1	6292
ATP-dependent helicase activity	6.3884E-3	16	48	2	6292
purine NTP-dependent helicase activity	6.3884E-3	16	48	2	6292
rRNA (guanine) methyltransferase activity	7.6106E-3	16	3	1	6292
rRNA (uridine) methyltransferase activity	7.6106E-3	16	3	1	6292
rRNA (uridine-2'-O-)-methyltransferase activity	7.6106E-3	16	3	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis