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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Bud20. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 23 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADH2
  • cytoplasm
  • fermentation
  • ethanol metabolic process
  • NADH oxidation
  • alcohol dehydrogenase (NAD) activity
  • AIM21
  • actin cytoskeleton
  • ribosome
  • biological_process
  • molecular_function
  • BUD20
  • nucleus
  • cellular bud site selection
  • ribosome biogenesis
  • molecular_function
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • COF1
  • actin cortical patch
  • actin filament severing
  • actin filament depolymerization
  • actin filament organization
  • protein binding
  • CPR1
  • nucleus
  • mitochondrion
  • histone deacetylase complex
  • ascospore formation
  • protein metabolic process
  • peptidyl-prolyl cis-trans isomerase activity
  • EHD3
  • mitochondrion
  • fatty acid beta-oxidation
  • endocytosis
  • 3-hydroxyisobutyryl-CoA hydrolase activity
  • GPI15
  • glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
  • GPI anchor biosynthetic process
  • UDP-glycosyltransferase activity
  • HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • HMO1
  • nucleus
  • nuclear chromatin
  • cytoplasm
  • nucleolus
  • telomere maintenance
  • plasmid maintenance
  • RNA polymerase I transcription factor activity
  • single-stranded DNA binding
  • HTB1
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • postreplication repair
  • DNA binding
  • HTB2
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • DNA binding
  • HYP2
  • cytoplasm
  • mitochondrion
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • protein binding
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • MAM33
  • mitochondrial matrix
  • mitochondrion
  • response to drug
  • aerobic respiration
  • molecular_function
  • MDH1
  • mitochondrial matrix
  • mitochondrion
  • malate metabolic process
  • tricarboxylic acid cycle
  • L-malate dehydrogenase activity
  • MGM101
  • mitochondrial chromosome
  • mitochondrion
  • mitochondrial nucleoid
  • DNA repair
  • mitochondrial genome maintenance
  • DNA binding
  • MRPS16
  • mitochondrion
  • mitochondrial small ribosomal subunit
  • translation
  • structural constituent of ribosome
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • RLP24
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • TEF4
  • mitochondrion
  • ribosome
  • eukaryotic translation elongation factor 1 complex
  • translational elongation
  • translation elongation factor activity
  • UTP20
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA processing
  • snoRNA binding
  • YFL006W

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    non-membrane-bounded organelle 7.0705E-7 23 959 14 6292
    intracellular non-membrane-bounded organelle 7.0705E-7 23 959 14 6292
    organelle lumen 6.4566E-6 23 660 11 6292
    intracellular organelle lumen 6.4566E-6 23 660 11 6292
    nuclear nucleosome 9.1897E-6 23 12 3 6292
    nucleosome 9.1897E-6 23 12 3 6292
    membrane-enclosed lumen 1.1476E-5 23 700 11 6292
    nuclear chromatin 1.2499E-4 23 73 4 6292
    chromatin 1.539E-4 23 77 4 6292
    nucleolus 8.3038E-4 23 211 5 6292
    nuclear lumen 8.5064E-4 23 453 7 6292
    protein-DNA complex 1.0978E-3 23 57 3 6292
    chromosome 2.6613E-3 23 274 5 6292
    mitochondrial matrix 3.4546E-3 23 176 4 6292
    mitochondrial lumen 3.4546E-3 23 176 4 6292
    intracellular organelle 3.9107E-3 23 4070 21 6292
    organelle 3.9279E-3 23 4071 21 6292
    intracellular organelle part 4.4397E-3 23 2282 15 6292
    organelle part 4.4397E-3 23 2282 15 6292
    nuclear chromosome part 4.5466E-3 23 190 4 6292
    macromolecular complex 6.4169E-3 23 1635 12 6292
    mitochondrial chromosome 7.2981E-3 23 2 1 6292
    cytoplasmic chromosome 7.2981E-3 23 2 1 6292
    replication fork protection complex 7.2981E-3 23 2 1 6292
    nuclear chromosome 8.6418E-3 23 228 4 6292
    ribonucleoprotein complex 8.7535E-3 23 514 6 6292
    chromosomal part 9.8808E-3 23 237 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromatin assembly or disassembly 2.5879E-4 23 35 3 6292
    histone H3-K79 methylation 3.6554E-3 23 1 1 6292
    actin filament severing 3.6554E-3 23 1 1 6292
    histone lysine methylation 7.2981E-3 23 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleic acid binding 3.2844E-4 23 666 9 6292
    DNA binding 1.9742E-3 23 256 5 6292
    binding 3.0991E-3 23 1294 11 6292
    3-hydroxyisobutyryl-CoA hydrolase activity 3.6554E-3 23 1 1 6292
    NADPH dehydrogenase activity 7.2981E-3 23 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle