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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Prp11. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADK1
  • mitochondrial intermembrane space
  • cytoplasm
  • mitochondrion
  • ADP biosynthetic process
  • nucleotide metabolic process
  • adenylate kinase activity
  • CLU1
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • mitochondrion organization
  • molecular_function
  • COP1
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • GPH1
  • cytoplasm
  • glycogen catabolic process
  • glycogen phosphorylase activity
  • NAN1
  • RENT complex
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • PRP11
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • REX2
  • mitochondrion
  • RNA processing
  • 3'-5' exonuclease activity
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • SHM2
  • cytoplasm
  • one-carbon metabolic process
  • glycine hydroxymethyltransferase activity
  • SSK2
  • cellular bud tip
  • cellular bud neck
  • cytosol
  • osmosensory signaling pathway
  • response to osmotic stress
  • protein amino acid phosphorylation
  • actin cytoskeleton organization
  • activation of MAPKK activity involved in osmosensory signaling pathway
  • MAP kinase kinase kinase activity
  • TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • protein metabolic process
  • vacuolar acidification
  • intron homing
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
  • THI22
  • cellular_component
  • thiamin biosynthetic process
  • phosphomethylpyrimidine kinase activity
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • UBP15
  • cytoplasm
  • protein deubiquitination
  • ubiquitin-specific protease activity
  • UTP13
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • snoRNA binding
  • YGR250C
  • cytoplasm
  • biological_process
  • RNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    COPI coated vesicle membrane 2.1602E-4 16 9 2 6292
    COPI vesicle coat 2.1602E-4 16 9 2 6292
    Golgi-associated vesicle membrane 7.1262E-4 16 16 2 6292
    COPI-coated vesicle 1.2379E-3 16 21 2 6292
    vesicle coat 3.2438E-3 16 34 2 6292
    coated vesicle membrane 3.4353E-3 16 35 2 6292
    cytoplasmic vesicle membrane 3.4353E-3 16 35 2 6292
    vesicle membrane 3.4353E-3 16 35 2 6292
    membrane coat 4.0408E-3 16 38 2 6292
    coated membrane 4.0408E-3 16 38 2 6292
    cytoplasmic vesicle part 4.2529E-3 16 39 2 6292
    Golgi-associated vesicle 4.4702E-3 16 40 2 6292
    Golgi membrane 6.6504E-3 16 49 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    retrograde vesicle-mediated transport, Golgi to ER 1.9016E-3 16 26 2 6292
    ADP biosynthetic process 2.5429E-3 16 1 1 6292
    ADP metabolic process 2.5429E-3 16 1 1 6292
    purine nucleoside diphosphate biosynthetic process 2.5429E-3 16 1 1 6292
    purine nucleoside diphosphate metabolic process 2.5429E-3 16 1 1 6292
    purine ribonucleoside diphosphate metabolic process 2.5429E-3 16 1 1 6292
    ribonucleoside diphosphate metabolic process 2.5429E-3 16 1 1 6292
    ribonucleoside diphosphate biosynthetic process 2.5429E-3 16 1 1 6292
    purine ribonucleoside diphosphate biosynthetic process 2.5429E-3 16 1 1 6292
    translational initiation 4.9198E-3 16 42 2 6292
    nucleoside diphosphate biosynthetic process 5.0798E-3 16 2 1 6292
    cellular metabolic process 7.176E-3 16 3033 13 6292
    activation of MAPKK activity involved in osmosensory signaling pathway 7.6106E-3 16 3 1 6292
    nucleoside diphosphate metabolic process 7.6106E-3 16 3 1 6292
    maturation of SSU-rRNA 9.5338E-3 16 59 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    phosphotransferase activity, phosphate group as acceptor 3.2905E-4 16 11 2 6292
    glycogen phosphorylase activity 2.5429E-3 16 1 1 6292
    phosphorylase activity 2.5429E-3 16 1 1 6292
    snoRNA binding 2.7007E-3 16 31 2 6292
    phosphomethylpyrimidine kinase activity 7.6106E-3 16 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle