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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Cmd1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CMD1
  • incipient cellular bud site
  • cellular bud tip
  • central plaque of spindle pole body
  • cytoplasm
  • cellular bud neck
  • mating projection tip
  • cytoskeleton organization
  • cell budding
  • vacuole fusion, non-autophagic
  • mitosis
  • endocytosis
  • protein binding
  • calcium ion binding
  • calcium-dependent protein binding
  • CMK2
  • cytoplasm
  • signal transduction
  • protein amino acid phosphorylation
  • adenosine deaminase activity
  • CMP2
  • calcineurin complex
  • cytoplasm
  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
  • cellular ion homeostasis
  • calcium-dependent protein serine/threonine phosphatase activity
  • COF1
  • actin cortical patch
  • actin filament severing
  • actin filament depolymerization
  • actin filament organization
  • protein binding
  • CPR1
  • nucleus
  • mitochondrion
  • histone deacetylase complex
  • ascospore formation
  • protein metabolic process
  • peptidyl-prolyl cis-trans isomerase activity
  • EDE1
  • cellular bud tip
  • cellular bud neck
  • actin cortical patch
  • endocytosis
  • ubiquitin binding
  • HCH1
  • nucleus
  • cytoplasm
  • telomere maintenance
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • HYP2
  • cytoplasm
  • mitochondrion
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • protein binding
  • ILS1
  • cytosol
  • translation
  • isoleucine-tRNA ligase activity
  • IPP1
  • cytosol
  • phosphate metabolic process
  • inorganic diphosphatase activity
  • MYO2
  • incipient cellular bud site
  • cellular bud tip
  • cellular bud neck
  • fungal-type vacuole membrane
  • myosin V complex
  • mating projection tip
  • vesicle
  • filamentous actin
  • mitochondrion inheritance
  • vacuole inheritance
  • establishment of mitotic spindle orientation
  • unidimensional cell growth
  • vesicle-mediated transport
  • Golgi inheritance
  • vesicle transport along actin filament
  • peroxisome inheritance
  • membrane addition at site of cytokinesis
  • budding cell apical bud growth
  • actin filament binding
  • calmodulin binding
  • microfilament motor activity
  • MYO4
  • cellular bud
  • mitochondrion
  • myosin V complex
  • filamentous actin
  • intracellular mRNA localization
  • endoplasmic reticulum inheritance
  • gene conversion at mating-type locus
  • actin filament binding
  • microfilament motor activity
  • MYO5
  • actin cortical patch
  • response to salt stress
  • bipolar cellular bud site selection
  • response to osmotic stress
  • cellular cell wall organization
  • endocytosis
  • exocytosis
  • microfilament motor activity
  • PGM2
  • cytosol
  • response to temperature stimulus
  • energy reserve metabolic process
  • UDP-glucose metabolic process
  • trehalose biosynthetic process
  • alcohol metabolic process
  • glucose metabolic process
  • cellular calcium ion homeostasis
  • vacuolar protein catabolic process
  • carbohydrate metabolic process
  • glycogen biosynthetic process
  • glucose 6-phosphate metabolic process
  • cellular carbohydrate metabolic process
  • galactose catabolic process
  • glucose 1-phosphate metabolic process
  • cellular cation homeostasis
  • phosphoglucomutase activity
  • PST2
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • SHE3
  • cytoplasm
  • actin cap
  • intracellular mRNA localization
  • endoplasmic reticulum inheritance
  • gene conversion at mating-type locus
  • mRNA binding
  • SOD1
  • mitochondrial intermembrane space
  • mitochondrion
  • cytosol
  • age-dependent response to reactive oxygen species involved in chronological cell aging
  • response to cold
  • superoxide metabolic process
  • cellular copper ion homeostasis
  • response to drug
  • cellular zinc ion homeostasis
  • antioxidant activity
  • metal ion binding
  • oxidoreductase activity
  • superoxide dismutase activity
  • UBA1
  • nucleus
  • cytoplasm
  • ubiquitin cycle
  • ubiquitin activating enzyme activity
  • VAS1
  • cytoplasm
  • mitochondrion
  • valyl-tRNA aminoacylation
  • valine-tRNA ligase activity
  • VPS13
  • endosome
  • mitochondrion
  • extrinsic to membrane
  • ascospore formation
  • protein retention in Golgi apparatus
  • late endosome to vacuole transport
  • vacuolar protein catabolic process
  • molecular_function
  • YNK1
  • mitochondrial intermembrane space
  • mitochondrion
  • cytosol
  • RNA metabolic process
  • purine nucleotide biosynthetic process
  • nucleoside triphosphate biosynthetic process
  • nucleoside diphosphate phosphorylation
  • DNA metabolic process
  • nucleotide metabolic process
  • nucleoside diphosphate kinase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    actin cytoskeleton 2.3468E-7 21 85 6 6292
    cytoskeletal part 2.4311E-6 21 201 7 6292
    cytoskeleton 3.9339E-6 21 216 7 6292
    cytoplasm 5.945E-6 21 3552 21 6292
    myosin V complex 1.0611E-5 21 2 2 6292
    filamentous actin 1.0611E-5 21 2 2 6292
    unconventional myosin complex 1.0611E-5 21 2 2 6292
    cortical actin cytoskeleton 2.2381E-5 21 52 4 6292
    cortical cytoskeleton 2.2381E-5 21 52 4 6292
    myosin complex 3.1768E-5 21 3 2 6292
    cytoplasmic part 1.2362E-4 21 2482 17 6292
    cell cortex part 2.4961E-4 21 96 4 6292
    actin cortical patch 3.1488E-4 21 41 3 6292
    actin filament 3.7663E-4 21 9 2 6292
    cell cortex 4.0637E-4 21 109 4 6292
    cellular bud tip 8.3512E-4 21 57 3 6292
    cellular bud 1.9685E-3 21 166 4 6292
    cytosol 2.0262E-3 21 284 5 6292
    mating projection tip 5.9079E-3 21 35 2 6292
    intracellular part 6.1098E-3 21 4938 21 6292
    mitochondrial intermembrane space 6.2428E-3 21 36 2 6292
    intracellular 7.149E-3 21 4975 21 6292
    organelle envelope lumen 7.6675E-3 21 40 2 6292
    cell projection part 8.4298E-3 21 42 2 6292
    cellular bud neck 8.548E-3 21 129 3 6292
    non-membrane-bounded organelle 9.0534E-3 21 959 8 6292
    intracellular non-membrane-bounded organelle 9.0534E-3 21 959 8 6292
    incipient cellular bud site 9.6347E-3 21 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    reproduction of a single-celled organism 4.057E-6 21 217 7 6292
    reproduction 5.6108E-6 21 328 8 6292
    endoplasmic reticulum inheritance 1.0611E-5 21 2 2 6292
    developmental process 6.4128E-5 21 331 7 6292
    endoplasmic reticulum organization 1.5788E-4 21 6 2 6292
    cellular developmental process 2.0957E-4 21 276 6 6292
    organelle inheritance 3.887E-4 21 44 3 6292
    intracellular mRNA localization 4.6984E-4 21 10 2 6292
    gene conversion at mating-type locus 5.731E-4 21 11 2 6292
    reproductive process in single-celled organism 8.8833E-4 21 134 4 6292
    vacuolar protein catabolic process 9.4251E-4 21 14 2 6292
    mating type switching 1.2379E-3 21 16 2 6292
    cell differentiation 1.2878E-3 21 148 4 6292
    reproductive developmental process 1.3875E-3 21 151 4 6292
    mating type determination 1.9443E-3 21 20 2 6292
    sex determination 1.9443E-3 21 20 2 6292
    cell fate commitment 2.5734E-3 21 23 2 6292
    endocytosis 2.9304E-3 21 88 3 6292
    cell budding 3.1238E-3 21 90 3 6292
    asexual reproduction 3.1238E-3 21 90 3 6292
    nucleoside diphosphate phosphorylation 3.3376E-3 21 1 1 6292
    nucleotide phosphorylation 3.3376E-3 21 1 1 6292
    valyl-tRNA aminoacylation 3.3376E-3 21 1 1 6292
    actin filament severing 3.3376E-3 21 1 1 6292
    Golgi inheritance 3.3376E-3 21 1 1 6292
    superoxide metabolic process 3.3376E-3 21 1 1 6292
    membrane invagination 3.5338E-3 21 94 3 6292
    cellular membrane organization 3.7382E-3 21 198 4 6292
    membrane organization 3.7382E-3 21 198 4 6292
    vesicle-mediated transport 4.439E-3 21 340 5 6292
    response to temperature stimulus 4.6543E-3 21 31 2 6292
    reproductive cellular process 4.695E-3 21 211 4 6292
    reproductive process 4.7749E-3 21 212 4 6292
    mitotic recombination 5.2637E-3 21 33 2 6292
    response to abiotic stimulus 6.5278E-3 21 117 3 6292
    developmental growth involved in morphogenesis 6.6645E-3 21 2 1 6292
    vesicle transport along actin filament 6.6645E-3 21 2 1 6292
    actin filament-based movement 6.6645E-3 21 2 1 6292
    developmental growth 6.6645E-3 21 2 1 6292
    glucose 1-phosphate metabolic process 6.6645E-3 21 2 1 6292
    unidimensional cell growth 6.6645E-3 21 2 1 6292
    age-dependent response to reactive oxygen species 6.6645E-3 21 2 1 6292
    age-dependent response to reactive oxygen species involved in chronological cell aging 6.6645E-3 21 2 1 6292
    glucose 6-phosphate metabolic process 6.6645E-3 21 2 1 6292
    membrane addition at site of cytokinesis 6.6645E-3 21 2 1 6292
    cellular ion homeostasis 6.842E-3 21 119 3 6292
    cellular chemical homeostasis 6.842E-3 21 119 3 6292
    cellular homeostasis 7.0024E-3 21 120 3 6292
    chemical homeostasis 7.4971E-3 21 123 3 6292
    ion homeostasis 7.4971E-3 21 123 3 6292
    regulation of biological quality 7.6007E-3 21 551 6 6292
    anatomical structure morphogenesis 9.3948E-3 21 257 4 6292
    anatomical structure development 9.7796E-3 21 260 4 6292
    nucleoside diphosphate metabolic process 9.9809E-3 21 3 1 6292
    peroxisome inheritance 9.9809E-3 21 3 1 6292
    UDP-glucose metabolic process 9.9809E-3 21 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    microfilament motor activity 3.1914E-7 21 5 3 6292
    motor activity 2.5324E-5 21 18 3 6292
    actin filament binding 6.8633E-4 21 12 2 6292
    actin binding 2.1446E-3 21 21 2 6292
    protein binding 2.7411E-3 21 612 7 6292
    nucleoside diphosphate kinase activity 3.3376E-3 21 1 1 6292
    calmodulin binding 3.3376E-3 21 1 1 6292
    valine-tRNA ligase activity 3.3376E-3 21 1 1 6292
    ubiquitin activating enzyme activity 3.3376E-3 21 1 1 6292
    calcium-dependent protein binding 3.3376E-3 21 1 1 6292
    superoxide dismutase activity 6.6645E-3 21 2 1 6292
    phosphoglucomutase activity 6.6645E-3 21 2 1 6292
    inorganic diphosphatase activity 6.6645E-3 21 2 1 6292
    isoleucine-tRNA ligase activity 6.6645E-3 21 2 1 6292
    oxidoreductase activity, acting on superoxide radicals as acceptor 6.6645E-3 21 2 1 6292
    aminoacyl-tRNA ligase activity 6.9383E-3 21 38 2 6292
    ligase activity, forming aminoacyl-tRNA and related compounds 6.9383E-3 21 38 2 6292
    ligase activity, forming carbon-oxygen bonds 6.9383E-3 21 38 2 6292
    catalytic activity 8.5084E-3 21 2150 13 6292
    chaperone activator activity 9.9809E-3 21 3 1 6292
    calcium-dependent protein serine/threonine phosphatase activity 9.9809E-3 21 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle